Search Results - "Tekmal, R R"

Significance of PELP1/HDAC2/miR-200 regulatory network in EMT and metastasis of breast cancer by Roy, S S, Gonugunta, V K, Bandyopadhyay, A, Rao, M K, Goodall, G J, Sun, L-Z, Tekmal, R R, Vadlamudi, R K

“…Tumor metastasis is the leading cause of death among breast cancer patients. PELP1 (proline, glutamic acid and leucine rich protein 1) is a nuclear receptor…”
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Astrocyte-Derived Estrogen Regulates Reactive Astrogliosis and is Neuroprotective following Ischemic Brain Injury by Wang, Jing, Sareddy, Gangadhara R, Lu, Yujiao, Pratap, Uday P, Tang, Fulei, Greene, Karah M, Meyre, Pornjittra L, Tekmal, Rajeshwar R, Vadlamudi, Ratna K, Brann, Darrell W

“…Expression of the 17β-estradiol (E2) synthesis enzyme aromatase is highly upregulated in astrocytes following brain injury. However, the precise role of…”
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Lysine-specific histone demethylase 1A (KDM1A/LSD1) inhibition attenuates DNA double-strand break repair and augments the efficacy of temozolomide in glioblastoma by Alejo, Salvador, Palacios, Bridgitte E, Venkata, Prabhakar Pitta, He, Yi, Li, Wenjing, Johnson, Jessica D, Chen, Yihong, Jayamohan, Sridharan, Pratap, Uday P, Clarke, Kyra, Zou, Yi, Lv, Yingli, Weldon, Korri, Viswanadhapalli, Suryavathi, Lai, Zhao, Ye, Zhenqing, Chen, Yidong, Gilbert, Andrea R, Suzuki, Takayoshi, Tekmal, Rajeshwar R, Zhao, Weixing, Zheng, Siyuan, Vadlamudi, Ratna K, Brenner, Andrew J, Sareddy, Gangadhara R

“…Abstract Background Efficient DNA repair in response to standard chemo and radiation therapies often contributes to glioblastoma (GBM) therapy resistance…”
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Akt-induced endocrine therapy resistance is reversed by inhibition of mTOR signaling by Beeram, M, Tan, Q-TN, Tekmal, RR, Russell, D, Middleton, A, deGraffenried, LA

“…Background: Resistance to endocrine therapy is a major impediment in breast cancer therapeutics. The Phosphatidylinositol-3-OH kinase (PI3K)/Protein kinase B…”
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EC359: A First-in-Class Small-Molecule Inhibitor for Targeting Oncogenic LIFR Signaling in Triple-Negative Breast Cancer by Viswanadhapalli, Suryavathi, Luo, Yiliao, Sareddy, Gangadhara R, Santhamma, Bindu, Zhou, Mei, Li, Mengxing, Ma, Shihong, Sonavane, Rajni, Pratap, Uday P, Altwegg, Kristin A, Li, Xiaonan, Chang, Annabel, Chávez-Riveros, Alejandra, Dileep, Kalarickal V, Zhang, Kam Y J, Pan, Xinlei, Murali, Ramachandran, Bajda, Marek, Raj, Ganesh V, Brenner, Andrew J, Manthati, Vijaya, Rao, Manjeet K, Tekmal, Rajeshwar R, Nair, Hareesh B, Nickisch, Klaus J, Vadlamudi, Ratna K

“…Leukemia inhibitory factor receptor (LIFR) and its ligand LIF play a critical role in cancer progression, metastasis, stem cell maintenance, and therapy…”
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KDM1A inhibition is effective in reducing stemness and treating triple negative breast cancer by Zhou, Mei, Venkata, Prabhakar Pitta, Viswanadhapalli, Suryavathi, Palacios, Bridgitte, Alejo, Salvador, Chen, Yihong, He, Yi, Pratap, Uday P., Liu, Junhao, Zou, Yi, Lai, Zhao, Suzuki, Takayoshi, Brenner, Andrew J., Tekmal, Rajeshwar R., Vadlamudi, Ratna K., Sareddy, Gangadhara R.

“…Purpose Cancer stem cells (CSCs) are highly tumorigenic, spared by chemotherapy, sustain tumor growth, and are implicated in tumor recurrence after…”
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Neuron-Derived Estrogen-A Key Neuromodulator in Synaptic Function and Memory by Brann, Darrell W, Lu, Yujiao, Wang, Jing, Sareddy, Gangadhara R, Pratap, Uday P, Zhang, Quanguang, Tekmal, Rajeshwar R, Vadlamudi, Ratna K

“…In addition to being a steroid hormone, 17β-estradiol (E ) is also a neurosteroid produced in neurons in various regions of the brain of many species,…”
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SETDB1 interactions with PELP1 contributes to breast cancer endocrine therapy resistance by Liu, Zexuan, Liu, Junhao, Ebrahimi, Behnam, Pratap, Uday P, He, Yi, Altwegg, Kristin A, Tang, Weiwei, Li, Xiaonan, Lai, Zhao, Chen, Yidong, Shen, Liangfang, Sareddy, Gangadhara R, Viswanadhapalli, Suryavathi, Tekmal, Rajeshwar R, Rao, Manjeet K, Vadlamudi, Ratna K

“…Methyltransferase SETDB1 is highly expressed in breast cancer (BC), however, the mechanisms by which SETDB1 promotes BC progression to endocrine therapy…”
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KDM1A inhibition augments the efficacy of rapamycin for the treatment of endometrial cancer by Venkata, Prabhakar Pitta, Chen, Yihong, Alejo, Salvador, He, Yi, Palacios, Bridgitte E., Loeffel, Ilanna, Liu, Junhao, Pratap, Uday P., Gray, Gabrielle, Achuthan Pillai, Sureshkumar Mulampurath, Zou, Yi, Lai, Zhao, Suzuki, Takayoshi, Viswanadhapalli, Suryavathi, Palakurthi, Srinath, Tekmal, Rajeshwar R., Vadlamudi, Ratna K., Kost, Edward, Sareddy, Gangadhara R.

“…Endometrial cancer (EC) often exhibit aberrant activation of PI3K/Akt/mTOR signaling and targeted therapies using mTOR inhibitors showed limited success. The…”
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Therapeutic Targeting of Ovarian Cancer Stem Cells Using Estrogen Receptor Beta Agonist by He, Yi, Alejo, Salvador, Venkata, Prabhakar Pitta, Johnson, Jessica D, Loeffel, Ilanna, Pratap, Uday P, Zou, Yi, Lai, Zhao, Tekmal, Rajeshwar R, Kost, Edward R, Sareddy, Gangadhara R

“…Ovarian cancer (OCa) is the deadliest gynecologic cancer. Emerging studies suggest ovarian cancer stem cells (OCSCs) contribute to chemotherapy resistance and…”
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NSAID Use Reduces Breast Cancer Recurrence in Overweight and Obese Women: Role of Prostaglandin-Aromatase Interactions by BOWERS, Laura W, MAXIMO, Ilane X. F, BRENNER, Andrew J, BEERAM, Muralidhar, HURSTING, Stephen D, PRICE, Ramona S, TEKMAL, Rajeshwar R, JOLLY, Christopher A, DEGRAFFENRIED, Linda A

“…Obesity is associated with a worse breast cancer prognosis and elevated levels of inflammation, including greater cyclooxygenase-2 (COX-2) expression and…”
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Estrogen receptor beta enhances chemotherapy response of GBM cells by down regulating DNA damage response pathways by Zhou, Mei, Sareddy, Gangadhara R., Li, Mengxing, Liu, Jinyou, Luo, Yiliao, Venkata, Prabhakar Pitta, Viswanadhapalli, Suryavathi, Tekmal, Rajeshwar R., Brenner, Andrew, Vadlamudi, Ratna K.

“…Glioblastoma (GBM) is the most commonly diagnosed brain tumor that exhibit high mortality rate and chemotherapy resistance is a major clinical problem. Recent…”
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Obesity-associated systemic interleukin-6 promotes pre-adipocyte aromatase expression via increased breast cancer cell prostaglandin E2 production by Bowers, Laura W., Brenner, Andrew J., Hursting, Stephen D., Tekmal, Rajeshwar R., deGraffenried, Linda A.

“…Obesity is associated with a worse breast cancer prognosis, particularly in estrogen receptor alpha (ERα) positive, postmenopausal patients. We hypothesized…”
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Brain-Derived Estrogen and Neurological Disorders by Brann, Darrell W, Lu, Yujiao, Wang, Jing, Sareddy, Gangadhara R, Pratap, Uday P, Zhang, Quanguang, Tekmal, Rajeshwar R, Vadlamudi, Ratna K

“…Astrocytes and neurons in the male and female brains produce the neurosteroid brain-derived 17β-estradiol (BDE ) from androgen precursors. In this review, we…”
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Aromatase expression increases the survival and malignancy of estrogen receptor positive breast cancer cells by Mukhopadhyay, Keya De, Liu, Zhao, Bandyopadhyay, Abhik, Kirma, Nameer B, Tekmal, Rajeshwar R, Wang, Shui, Sun, Lu-Zhe

“…In postmenopausal women, local estrogen produced by adipose stromal cells in the breast is believed to support estrogen receptor alpha (ERα) positive breast…”
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Development and Characterization of Inducible Astrocyte-Specific Aromatase Knockout Mice by Wang, Jing, Pratap, Uday P, Lu, Yujiao, Sareddy, Gangadhara R, Tekmal, Rajeshwar R, Vadlamudi, Ratna K, Brann, Darrell W

“…17β-estradiol (E2) is produced in the brain as a neurosteroid, in addition to being an endocrine signal in the periphery. The current animal models for…”
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Opium Alkaloid Noscapine is an Antitumor Agent that Arrests Metaphase and Induces Apoptosis in Dividing Cells by Ye, Keqiang, Ke, Yong, Keshava, Nagalakshmi, Shanks, John, Kapp, Judith A., Tekmal, Rajeshwar R., Petros, John, Joshi, Harish C.

“…An alkaloid from opium, noscapine, is used as an antitussive drug and has low toxicity in humans and mice. We show that noscapine binds stoichiometrically to…”
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Proline, glutamic acid and leucine-rich protein-1 is essential for optimal p53-mediated DNA damage response by Nair, B C, Krishnan, S R, Sareddy, G R, Mann, M, Xu, B, Natarajan, M, Hasty, P, Brann, D, Tekmal, R R, Vadlamudi, R K

“…Proline-, glutamic acid- and leucine-rich protein-1 (PELP1) is a scaffolding oncogenic protein that functions as a coregulator for a number of nuclear…”
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Induction of endometrial epithelial cell invasion and c-fms expression by transforming growth factor beta by Liu, Ya-guang, Tekmal, Rajeshwar R., Binkley, Peter A., Nair, Hareesh B., Schenken, Robert S., Kirma, Nameer B.

“…Transforming growth factor beta 1 (TGF-β1) levels are increased in the peritoneal fluid of endometriosis patients, and endometrial cells express TGF-β…”
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A potential role for colony-stimulating factor 1 in the genesis of the early endometriotic lesion by Jensen, Jani R., M.D, Witz, Craig A., M.D, Schenken, Robert S., M.D, Tekmal, Rajeshwar R., Ph.D

“…Objective To investigate the role(s) of colony-stimulating factor 1 (CSF-1) on the development of early endometriosis in a murine model by comparing rate of…”
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