Fluconazole Ocuserts: Formulation and Evaluation

Fluconazole Ocuserts: Formulation and Evaluation

Keywords: Film forming polymers, In- vitro drug release, Ocular inserts and Solvent casting technique Introduction Fluconazole, a synthetic antifungal agent, is a triazole derivative used in the treatment of a wide range of fungal infections and it belongs to class II of biopharmaceutical classifica...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences and research Vol. 10; no. 1; pp. 26 - 30
Main Authors: Rao, S Venkateswara, Tejaswi, B C D, Anusha, A, Padmalatha, K
Format: Journal Article
Language:English
Published: Cuddalore Journal of Pharmaceutical Sciences and Research 01-01-2018
Subjects:
Antifungal agents
Bioavailability
Cellulose
Cornea
Drug delivery systems
Fourier transforms
Fungal infections
Laboratories
Moisture absorption
Motion pictures
Pharmaceuticals
Polymers
Polyvinyl alcohol
Prescription drugs
Solvents
Spectrum analysis
Studies
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Summary:Keywords: Film forming polymers, In- vitro drug release, Ocular inserts and Solvent casting technique Introduction Fluconazole, a synthetic antifungal agent, is a triazole derivative used in the treatment of a wide range of fungal infections and it belongs to class II of biopharmaceutical classification system (BCS) having low water solubility [1]. Melting Point Determination After performing capillary method melting point of Fluconazole found in range of 139-140°C Identification of Pure Drug FT-IR spectroscopy was used to determine the functional group present in the pure drug sample.The spectrum of Fluconazole presenting the characteristic peak of triazole group C-H stretching at 2956cm-1, C-F stretching at 1275.76cm-1, 2.4-Difluorobenzyl group at 1619.47 cm-1 presenting C=C stretching vibration, peak at 1422.39 cm-1 was due to CH2 stretching vibration and peak at 1140.97cm-1 was due to C-C stretching vibration. The maximum surface pH observed was 6.9 ± 0.116 for F-6 and minimum observed was 6.3 ± 0.117 for F-1. [...]the observed pH which was in neutral range shows the suitability of inserts to be used for ophthalmic application. No sign of redness, inflammation, or increased tear production were observed. [...]results of the test have shown that there were no signs of irritation observed.
ISSN:0975-1459