Splicing Regulators and Their Roles in Cancer Biology and Therapy

Splicing Regulators and Their Roles in Cancer Biology and Therapy

Alternative splicing allows cells to expand the encoding potential of their genomes. In this elegant mechanism, a single gene can yield protein isoforms with even antagonistic functions depending on the cellular physiological context. Alterations in splicing regulatory factors activity in cancer cel...

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Bibliographic Details
Published in:BioMed research international Vol. 2015; no. 2015; pp. 1 - 12
Main Authors: Bressan, Gustavo Costa, Fietto, Juliana Lopes Rangel, Almeida, Márcia Rogéria, Teixera, Róbson Ricardo, Pais Siqueira, Raoni, de Almeida Alves Barbosa, Éverton, Gonçalves da Silva, Ronni Anderson, Moreira, Gabriela Alves, da Silva, Maria Roméria, Silva Júnior, Abelardo
Format: Journal Article
Language:English
Published: Cairo, Egypt Hindawi Publishing Corporation 01-01-2015
John Wiley & Sons, Inc
Hindawi Limited
Subjects:
Alternative Splicing - genetics
Animals
Apoptosis
Biology
Biomarkers, Tumor - genetics
Biomedical research
Cancer
Cancer therapies
Care and treatment
Disease
Gene expression
Gene Expression Regulation, Neoplastic - genetics
Genes
Genetic aspects
Genetic Markers - genetics
Genetic Therapy - methods
Health aspects
Humans
Kinases
Medical prognosis
Neoplasm Proteins - genetics
Neoplasms - diagnosis
Neoplasms - genetics
Neoplasms - therapy
Proteins
Regulation
Review
Signal transduction
Tumors
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Description
Summary:Alternative splicing allows cells to expand the encoding potential of their genomes. In this elegant mechanism, a single gene can yield protein isoforms with even antagonistic functions depending on the cellular physiological context. Alterations in splicing regulatory factors activity in cancer cells, however, can generate an abnormal protein expression pattern that promotes growth, survival, and other processes, which are relevant to tumor biology. In this review, we discuss dysregulated alternative splicing events and regulatory factors that impact pathways related to cancer. The SR proteins and their regulatory kinases SRPKs and CLKs have been frequently found altered in tumors and are examined in more detail. Finally, perspectives that support splicing machinery as target for the development of novel anticancer therapies are discussed.
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Academic Editor: Maria Paola Paronetto
ISSN:2314-6133
2314-6141
DOI:10.1155/2015/150514