Search Results - "Teixeira, Pedro F."

Shredding the signal: targeting peptide degradation in mitochondria and chloroplasts by Kmiec, Beata, Teixeira, Pedro F., Glaser, Elzbieta

“…•The targeting of most proteins to mitochondria and chloroplasts is dependent on N-terminal targeting signals.•N-terminal targeting signals are cleaved off…”
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Mechanism of Peptide Binding and Cleavage by the Human Mitochondrial Peptidase Neurolysin by Teixeira, Pedro F., Masuyer, Geoffrey, Pinho, Catarina M., Branca, Rui M.M., Kmiec, Beata, Wallin, Cecilia, Wärmländer, Sebastian K.T.S., Berntsson, Ronnie P.-A., Ankarcrona, Maria, Gräslund, Astrid, Lehtiö, Janne, Stenmark, Pål, Glaser, Elzbieta

“…Proteolysis plays an important role in mitochondrial biogenesis, from the processing of newly imported precursor proteins to the degradation of mitochondrial…”
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Accumulation of endogenous peptides triggers a pathogen stress response in Arabidopsis thaliana by Kmiec, Beata, Branca, Rui M.M., Berkowitz, Oliver, Li, Lu, Wang, Yan, Murcha, Monika W., Whelan, James, Lehtiö, Janne, Glaser, Elzbieta, Teixeira, Pedro F.

“…Summary The stepwise degradation of peptides to amino acids in plant mitochondria and chloroplasts is catalyzed by a network of oligopeptidases (presequence…”
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Inactivation of Mitochondrial Complex Ⅰ Induces the Expression of a Twin Cysteine Protein that Targets and Affects Cytosolic, Chloroplastidic and Mitochondrial Function by Wang, Yan, Lyu, Wenhui, Berkowitz, Oliver, Radomiljac, Jordan D., Law, Simon R., Murcha, Monika W., Carrie, Chris, Teixeira, Pedro F., Kmiec, Beata, Duncan, Owen, Van Aken, Olivier, Narsai, Reena, Glaser, Elzbieta, Huang, Shaobai, Roessner, Ute, Millar, A. Harvey, Whelan, James

“…At12Cys-1 （At5g64400） and At12Cys-2 （At5g09570） are two closely related isogenes that encode small, twin cysteine proteins, typically located in mitochondria…”
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Phenotypical consequences of expressing the dually targeted Presequence Protease, AtPreP, exclusively in mitochondria by Kmiec, Beata, Teixeira, Pedro F, Glaser, Elzbieta

“…Endosymbiotic organelles, mitochondria and chloroplasts, are sites of an intensive protein synthesis and degradation. A consequence of these processes is…”
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Divergent evolution of the M3A family of metallopeptidases in plants by Kmiec, Beata, Teixeira, Pedro F., Murcha, Monika W., Glaser, Elzbieta

“…Plants, as stationary organisms, have developed mechanisms allowing them efficient resource reallocation and a response to changing environmental conditions…”
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Phase III, randomised, double-blind, placebo-controlled, multicentre trial to evaluate the efficacy and safety of rhGAD65 to preserve endogenous beta cell function in adolescents and adults with recently diagnosed type 1 diabetes, carrying the genetic HLA DR3-DQ2 haplotype: the DIAGNODE-3 study protocol by Ludvigsson, Johnny, Eriksson, Linnea, Nowak, Christoph, Teixeira, Pedro F, Widman, Martina, Lindqvist, Anton, Casas, Rosaura, Lind, Marcus, Hannelius, Ulf

“…IntroductionType 1 diabetes (T1D) is an autoimmune disease leading to the destruction of the insulin-producing beta cells resulting in insulin deficiency and…”
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Organellar oligopeptidase (OOP) provides a complementary pathway for targeting peptide degradation in mitochondria and chloroplasts by Kmiec, Beata, Teixeira, Pedro F, Berntsson, Ronnie P-A, Murcha, Monika W, Branca, Rui M M, Radomiljac, Jordan D, Regberg, Jakob, Svensson, Linda M, Bakali, Amin, Langel, Ulo, Lehtiö, Janne, Whelan, James, Stenmark, Pål, Glaser, Elzbieta

“…Both mitochondria and chloroplasts contain distinct proteolytic systems for precursor protein processing catalyzed by the mitochondrial and stromal processing…”
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The dual-targeted prolyl aminopeptidase PAP1 is involved in proline accumulation in response to stress and during pollen development by Ghifari, Abi S, Teixeira, Pedro F, Kmiec, Beata, Singh, Neha, Glaser, Elzbieta, Murcha, Monika W

“…The Arabidopsis prolyl aminopeptidase PAP1 is involved in maintaining proline homeostasis by the release of N-terminal proline. PAP1 is targeted to both…”
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A mitochondrial prolyl aminopeptidase PAP2 releases N‐terminal proline and regulates proline homeostasis during stress response by Ghifari, Abi S., Teixeira, Pedro F., Kmiec, Beata, Pružinská, Adriana, Glaser, Elzbieta, Murcha, Monika W.

“…Amino acid recovery is the last step of organellar targeting peptide processing pathways, and prior studies have identified the metallo‐aminopeptidases…”
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Protein import into plant mitochondria: signals, machinery, processing, and regulation by Murcha, Monika W, Kmiec, Beata, Kubiszewski-Jakubiak, Szymon, Teixeira, Pedro F, Glaser, Elzbieta, Whelan, James

“…The majority of more than 1000 proteins present in mitochondria are imported from nuclear-encoded, cytosolically synthesized precursor proteins. This…”
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Assisting the implementation of screening for type 1 diabetes by using artificial intelligence on publicly available data by Teixeira, Pedro F., Battelino, Tadej, Carlsson, Anneli, Gudbjörnsdottir, Soffia, Hannelius, Ulf, von Herrath, Matthias, Knip, Mikael, Korsgren, Olle, Elding Larsson, Helena, Lindqvist, Anton, Ludvigsson, Johnny, Lundgren, Markus, Nowak, Christoph, Pettersson, Paul, Pociot, Flemming, Sundberg, Frida, Åkesson, Karin, Lernmark, Åke, Forsander, Gun

“…The type 1 diabetes community is coalescing around the benefits and advantages of early screening for disease risk. To be accepted by healthcare providers,…”
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A Mitochondrial LYR Protein Is Required for Complex I Assembly by Ivanova, Aneta, Gill-Hille, Mabel, Huang, Shaobai, Branca, Rui M, Kmiec, Beata, Teixeira, Pedro F, Lehtiö, Janne, Whelan, James, Murcha, Monika W

“…Complex I biogenesis requires the expression of both nuclear and mitochondrial genes, the import of proteins, cofactor biosynthesis, and the assembly of at…”
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A multi-step peptidolytic cascade for amino acid recovery in chloroplasts by Teixeira, Pedro F, Kmiec, Beata, Branca, Rui M M, Murcha, Monika W, Byzia, Anna, Ivanova, Aneta, Whelan, James, Drag, Marcin, Lehtiö, Janne, Glaser, Elzbieta

“…Mass spectrometry analysis of stromal extracts reveal a peptidolytic cascade in the plant chloroplast consisting of oligopeptidases and aminopeptidases that…”
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The novel component Kgd4 recruits the E3 subunit to the mitochondrial α-ketoglutarate dehydrogenase by Heublein, Manfred, Burguillos, Miguel A, Vögtle, F Nora, Teixeira, Pedro F, Imhof, Axel, Meisinger, Chris, Ott, Martin

“…The mitochondrial citric acid cycle is a central hub of cellular metabolism, providing intermediates for biosynthetic pathways and channeling electrons to the…”
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Plant-Specific Preprotein and Amino Acid Transporter Proteins Are Required for tRNA Import into Mitochondria by Murcha, Monika W., Kubiszewski-Jakubiak, Szymon, Teixeira, Pedro F., Gügel, Irene L., Kmiec, Beata, Narsai, Reena, Ivanova, Aneta, Megel, Cyrille, Schock, Annette, Kraus, Sabrina, Berkowitz, Oliver, Glaser, Elzbieta, Philippar, Katrin, Maréchal-Drouard, Laurence, Soll, Jürgen, Whelan, James

“…A variety of eukaryotes, in particular plants, do not contain the required number of tRNAs to support the translation of mitochondria-encoded genes and thus…”
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A Common Peptidolytic Mechanism for Targeting Peptide Degradation in Mitochondria and Chloroplasts by Kmiec, Beata, Branca, Rui M.M., Murcha, Monika W., Lehtiö, Janne, Glaser, Elzbieta, Teixeira, Pedro F.

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A flowchart to analyze protease activity in plant mitochondria by Teixeira, Pedro F, Branca, Rui M, Kmiec, Beata, Glaser, Elzbieta

“…Proteases are one of the most abundant classes of enzymes and are involved in a plethora of biological processes in many cellular compartments, including the…”
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The activity of adenylyltransferase in Rhodospirillum rubrum is only affected by α‐ketoglutarate and unmodified PII proteins, but not by glutamine, in vitro by Jonsson, Anders, Teixeira, Pedro F., Nordlund, Stefan

“…Ammonium assimilation is tightly regulated in nitrogen‐fixing bacteria; the target of regulation is primarily the activity of the key enzyme glutamine…”
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A Mitochondrial LYR Protein Is Required for Complex I Assembly1[OPEN] by Ivanova, Aneta, Gill-Hille, Mabel, Huang, Shaobai, Branca, Rui M., Kmiec, Beata, Teixeira, Pedro F., Lehtiö, Janne, Whelan, James, Murcha, Monika W.

“…A mitochondrial LYR protein is involved in the biogenesis of a matrix arm domain subunit of Complex I. Complex I biogenesis requires the expression of both…”
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