Metabolic and Behavior Changes in Surubim Acutely Exposed to a Glyphosate-Based Herbicide

This study examined the effect of glyphosate-based herbicide (Roundup Original), the major herbicide used in soybean crops in Mato Grosso state, at concentrations of 0, 2.25, 4.5, 7.5, and 15 mg L⁻¹ on metabolic and behavior parameters of the hybrid fish surubim in an acute exposure lasting 96 h. Gl...

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Published in:	Archives of environmental contamination and toxicology Vol. 67; no. 4; pp. 659 - 667
Main Authors:	Sinhorin, Valéria D. G, Sinhorin, Adilson P, Teixeira, Jhonnes Marcos S, Miléski, Kelly Márcia L, Hansen, Paula Carine, Moeller, Paulo Rafael, Moreira, Paula Sueli A, Baviera, Amanda M, Loro, Vânia L
Format:	Journal Article
Language:	English
Published:	Boston Springer-Verlag 01-11-2014 Springer US Springer Springer Nature B.V
Subjects:	acute exposure Agnatha. Pisces alanine transaminase Alanine Transaminase - metabolism Animal, plant and microbial ecology Animals Applied ecology Aquaculture Aspartate Aminotransferases - metabolism aspartate transaminase Behavior behavior change Biological and medical sciences blood glucose Cholesterol crops Drinking water Earth and Environmental Science Ecotoxicology Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on vertebrates Environment Environmental Chemistry Environmental Health Exposure Farms Fish Fishes - metabolism Fundamental and applied biological sciences. Psychology Glucose Glycine - analogs & derivatives Glycine - toxicity glycogen Glycogen - metabolism Glycogens glycolysis Glyphosate Herbicides Herbicides - toxicity hybrids Indicator organisms Lactates Liver Mammals Metabolism Monitoring/Environmental Analysis Muscles Neurotoxicity Pesticides Physiology Plasma Pollution Proteins Soil Science & Conservation Soybeans Studies Swimming Toxicity Water Pollutants, Chemical - toxicity Water pollution Brazil South America America Brazil, Mato Grosso Swimming Activity Ventilatory Frequency Roundup Glyphosate Glycogen Content Freshwater environment Vertebrata Toxicity Aminoacid Pisces Pesticides Behavior change Organic phosphonate Water pollution Herbicide
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Summary:	This study examined the effect of glyphosate-based herbicide (Roundup Original), the major herbicide used in soybean crops in Mato Grosso state, at concentrations of 0, 2.25, 4.5, 7.5, and 15 mg L⁻¹ on metabolic and behavior parameters of the hybrid fish surubim in an acute exposure lasting 96 h. Glycogen content, glucose, lactate, and protein levels were measured in different tissues. Plasma levels of cholesterol, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were also determined. Ventilatory frequency (VF) and swimming activity (SA) were considered behavior parameters. Results showed that herbicide exposure decreased plasma glucose levels and increased it in surubim liver. Lactate increased in both plasma and liver but decreased in muscle. Protein levels decreased in plasma and muscle but increased in liver. After herbicide exposure, liver and muscle glycogen was decreased. Cholesterol levels decreased in plasma at all concentrations tested. Plasma ALT increased, and no alterations were recorded for AST levels. VF increased after glyphosate exposure (5 min) and decreased after 96 h. SA showed differences among all groups (5 min). At the end of 96 h, SA was altered by the 7.5 mg L⁻¹ concentration. Fish used anaerobic glycolysis as indicated by generally decreased glycogen levels and decreased lactate levels in muscle but increased ones in plasma and liver. We suggest that the studied parameters could be used as indicators of herbicide toxicity in surubim and may provide extremely important information for understanding the biology of the animal and its responsiveness to external stimuli (stressors).
Bibliography:	http://dx.doi.org/10.1007/s00244-014-0073-z ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0090-4341 1432-0703
DOI:	10.1007/s00244-014-0073-z