Search Results - "Teige, Ingrid"

Accelerating target deconvolution for therapeutic antibody candidates using highly parallelized genome editing by Mattsson, Jenny, Ekdahl, Ludvig, Junghus, Fredrik, Ajore, Ram, Erlandsson, Eva, Niroula, Abhishek, Pertesi, Maroulio, Frendéus, Björn, Teige, Ingrid, Nilsson, Björn

“…Therapeutic antibodies are transforming the treatment of cancer and autoimmune diseases. Today, a key challenge is finding antibodies against new targets…”
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Targeting the Antibody Checkpoints to Enhance Cancer Immunotherapy-Focus on FcγRIIB by Teige, Ingrid, Mårtensson, Linda, Frendéus, Björn L

“…Immunotherapy with therapeutic antibodies has increased survival for patients with hematologic and solid cancers. Still, a significant fraction of patients…”
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A single-arm, open-label, phase 2 clinical trial evaluating disease response following treatment with BI-505, a human anti-intercellular adhesion molecule-1 monoclonal antibody, in patients with smoldering multiple myeloma by Wichert, Stina, Juliusson, Gunnar, Johansson, Åsa, Sonesson, Elisabeth, Teige, Ingrid, Wickenberg, Anna Teige, Frendeus, Björn, Korsgren, Magnus, Hansson, Markus

“…Smoldering multiple myeloma (SMM) is an indolent disease stage, considered to represent the transition phase from the premalignant MGUS (Monoclonal Gammopathy…”
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A Human ICAM-1 Antibody Isolated by a Function-First Approach Has Potent Macrophage-Dependent Antimyeloma Activity In Vivo by Veitonmäki, Niina, Hansson, Markus, Zhan, Fenghuang, Sundberg, Annika, Löfstedt, Tobias, Ljungars, Anne, Li, Zhan-Chun, Martinsson-Niskanen, Titti, Zeng, Ming, Yang, Ye, Danielsson, Lena, Kovacek, Mathilda, Lundqvist, Andrea, Mårtensson, Linda, Teige, Ingrid, Tricot, Guido, Frendéus, Björn

“…We isolated a tumor B-cell-targeting antibody, BI-505, from a highly diversified human phage-antibody library, using a pioneering “function-first” approach…”
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FcγRIIb Expression Is Decreased on Naive and Marginal Zone-Like B Cells From Females With Multiple Sclerosis by Trend, Stephanie, Leffler, Jonatan, Teige, Ingrid, Frendéus, Björn, Kermode, Allan G, French, Martyn A, Hart, Prue H

“…B cells are critical to the development of multiple sclerosis (MS), but the mechanisms by which they contribute to the disease are poorly defined. We…”
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Targeting FcγRIIB by antagonistic antibody BI-1206 improves the efficacy of rituximab-based therapies in aggressive mantle cell lymphoma by Jiang, Vivian Changying, Liu, Yang, Jordan, Alexa, Leeming, Angela, McIntosh, Joseph, Huang, Shengjian, Zhang, Rongjia, Cai, Qingsong, Chen, Zhihong, Li, Yijing, Che, Yuxuan, Nie, Lei, Karlsson, Ingrid, Mårtensson, Linda, Kovacek, Mathilda, Teige, Ingrid, Frendéus, Björn, Wang, Michael

“…Inevitable relapses remain as the major therapeutic challenge in patients with mantle cell lymphoma (MCL) despite FDA approval of multiple targeted therapies…”
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A Phase I Dose-Escalation Study of Antibody BI-505 in Relapsed/Refractory Multiple Myeloma by Hansson, Markus, Gimsing, Peter, Badros, Ashraf, Niskanen, Titti Martinsson, Nahi, Hareth, Offner, Fritz, Salomo, Morten, Sonesson, Elisabeth, Mau-Sorensen, Morten, Stenberg, Yvonne, Sundberg, Annika, Teige, Ingrid, Van Droogenbroeck, Jan, Wichert, Stina, Zangari, Maurizio, Frendeus, Björn, Korsgren, Magnus, Poelman, Martine, Tricot, Guido

“…This multicenter, first-in-human study evaluated safety, tolerability, pharmacokinetics, and pharmacodynamics of BI-505, a human anti-ICAM-1 monoclonal…”
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Vectorized Treg-depleting αCTLA-4 elicits antigen cross-presentation and CD8+ T cell immunity to reject ‘cold’ tumors by Semmrich, Monika, Marchand, Jean-Baptiste, Fend, Laetitia, Rehn, Matilda, Remy, Christelle, Holmkvist, Petra, Silvestre, Nathalie, Svensson, Carolin, Kleinpeter, Patricia, Deforges, Jules, Junghus, Fred, Cleary, Kirstie L, Bodén, Mimoza, Mårtensson, Linda, Foloppe, Johann, Teige, Ingrid, Quéméneur, Eric, Frendéus, Björn

“…BackgroundImmune checkpoint blockade (ICB) is a clinically proven concept to treat cancer. Still, a majority of patients with cancer including those with…”
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1368 Preclinical development of an agonistic anti-TNFR2 antibody (BI-1910) for cancer immunotherapy by Martensson, Linda, Holmkvist, Petra, Kovacek, Mathilda, Svensson, Carolin, Bodén, Mimoza, Cleary, Kirstie, Dadas, Osman, Blidberg, Therese, Duell, Benjamin, Semmrich, Monika, Nilsson, Jan Anders, Beers, Stephen, Lim, Sean, Wallin, Johan E, Borggren, Marie, McAllister, Andres, Cragg, Mark, Karlsson, Ingrid, Frendeus, Bjorn, Teige, Ingrid

“…BackgroundThe pleiotropic TNF-α:TNFR axis plays a central role in the immune system. TNFR2 has been proposed to be both essential for the survival of T regs,…”
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757 Phase 1/2a clinical trial of BI-1808, a monoclonal antibody to tumor necrosis factor receptor 2 (TNFR2) as single agent and in combination with pembrolizumab by Kristoffer Staahl Rohrberg, Papai, Zsuzsanna, Carneiro, Ana, Lang, Istvan, Yachnin, Jeffrey, Lim, Sean, Ny, Lars, Rikke H Lovendahl Eefsen, Walter, Harriet, Abel, Edvard, Cleary, Kirstie, Oldham, Robert, Cragg, Mark, Borggren, Marie, Gertsson, Susanne, Holmkvist, Petra, Karlsson, Ingrid, Martensson, Linda, Nilsson, Jan Anders, Wallin, Johan E, Chisamore, Michael, Frendeus, Bjorn, Teige, Ingrid, McAllister, Andres

“…BackgroundBI-1808 is a human IgG1 monoclonal antibody targeting TNFR2 by blocking the interaction of TNFR2 with its ligand TNF-α, confering FcγR-dependent…”
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Domain binding and isotype dictate the activity of anti-human OX40 antibodies by Griffiths, Jordana, Hussain, Khiyam, Smith, Hannah L, Sanders, Theodore, Cox, Kerry L, Semmrich, Monika, Mårtensson, Linda, Kim, Jinny, Inzhelevskaya, Tatyana, Penfold, Chris A, Tutt, Alison L, Mockridge, C Ian, Chan, HT Claude, English, Vikki, French, Ruth F, Teige, Ingrid, Al-Shamkhani, Aymen, Glennie, Martin J, Frendeus, Bjorn L, Willoughby, Jane E, Cragg, Mark S

“…BackgroundPrevious data suggests that anti-OX40 mAb can elicit anti-tumor effects in mice through deletion of Tregs. However, OX40 also has powerful…”
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TPA induction leads to a Th17-like response in transgenic K14/VEGF mice: a novel in vivo screening model of psoriasis by Hvid, Henning, Teige, Ingrid, Kvist, Peter Helding, Svensson, Lars, Kemp, Kåre

“…Psoriasis is a common chronic inflammatory skin disease, characterized by epidermal hyperplasia, immune cell infiltration, increased dermal angiogenesis and…”
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594 BT-001, an oncolytic vaccinia virus armed with a Treg-depleting human recombinant anti-CTLA4 antibody and GM-CSF to target the tumor microenvironment by Semmrich, Monika, Marchand, Jean-Baptiste, Fend, Laetitia, Rehn, Matilda, Silvestre, Nathalie, Mårtensson, Linda, Foloppe, Johann, Teige, Ingrid, Quéméneur, Eric, Frendeus, Björn

“…BackgroundCheckpoint inhibitor antibodies have improved survival in a variety of cancers, however, a great unmet need remains since only a small fraction of…”
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725 Pre-clinical development of TNFR2 ligand-blocking BI-1808 for cancer immunotherapy by Mårtensson, Linda, Kovacek, Mathilda, Holmkvist, Petra, Semmrich, Monika, Svensson, Carolin, Blidberg, Therese, Roos, Carl, McAllister, Andres, Demiri, Mimoza, Borggren, Marie, Karlsson, Ingrid, Frendeus, Björn, Teige, Ingrid

“…BackgroundThe pleiotropic TNF-alpha:TNFR axis plays a central role in the immune system. While the cellular expression of TNFR1 is broad, TNFR2 expression is…”
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TPA induction leads to a T[sub]h17-like response in transgenic K14/VEGF mice: a novel in vivo screening model of psoriasis by Hvid, Henning, Teige, Ingrid, Peter Helding Kvist, Svensson, Lars, Kemp, Kåre

“…Psoriasis is a common chronic inflammatory skin disease, characterized by epidermal hyperplasia, immune cell infiltration, increased dermal angiogenesis and…”
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Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies by Furness, Andrew J.S., Joshi, Kroopa, Rosenthal, Rachel, Ghorani, Ehsan, Spain, Lavinia, Ben Aissa, Assma, Smith, Myles, Strauss, Dirk, Hayes, Andrew, Nicol, David, Mårtensson, Linda, Harrington, Kevin, Wotherspoon, Andrew, Fernando, Archana, Chandra, Ashish, Rudman, Sarah, Varia, Mary, Polson, Alexander, Stamp, Gordon, Hill, Peter, Olsburgh, Jonathan, Lester, Jason, Attanoos, Richard, Adams, Haydn, Shaw, Jacqui, Le Quesne, John, Marshall, Hilary, Nelson, Louise, Bennett, Jonathan, Martinson, Luke, Kerr, Keith, Miller, Joy, Naidu, Babu, Langman, Gerald, Bellamy, Mary, Summers, Yvonne, Shah, Rajesh, Rammohan, Kendadai, Booton, Richard, Moss, Stuart, Idries, Faiza, Joseph, Leena, Chaturvedi, Anshuman, Marie Quinn, Anne, Doran, Helen, Waddington, Rachael, Blackhall, Fiona, Rogan, Jane, Smith, Elaine, Dive, Caroline, Brady, Ged, Chemie, Francesca, Tugwood, Jonathan, Lawrence, David, Panagiotopoulos, Nikolaos, Falzon, Mary, Borg, Elaine, Jamal-Hanjani, Mariam, Juul Birkbak, Nicolai, McGranahan, Nicholas, Goldman, Jacki, Veeriah, Raju, Johnson, Diana, Oukrif, Dahmane, Janes, Sam, Hartley, John, Kevin Stone, Richard, Denner, Tamara, Costa, Marta, Phillimore, Ben, Nye, Emma, Elgar, Greg, Al-Bakir, Maise, Navani, Neal, Gorman, Pat, MacKenzie, Mairead, Bell, Harriet, Hackshaw, Allan, Smith, Sean, Shaw, Emily, Lim, Eric, Nicholson, Andrew, Rice, Alexandra, Carlo Ronquillo, John, Mensah, Natalie, Finch, Jonathan, Lau, Kelvin, Schmid, Peter, Conibear, John, Danson, Sarah, Bury, Jonathan, Hill, Jennifer, Shackcloth, Michael, Feeney, Sarah, Asante-Siaw, Julius, Blyth, Kevin, Kirk, Alan, Pule, Martin, Turajlic, Samra, Peggs, Karl S.

“…With the use of a mouse model expressing human Fc-gamma receptors (FcγRs), we demonstrated that antibodies with isotypes equivalent to ipilimumab and…”
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Local therapy with CpG motifs in a murine model of allergic airway inflammation in IFN-beta knock-out mice by Matheu, Victor, Treschow, Alexandra, Teige, Ingrid, Navikas, Vaidrius, Issazadeh-Navikas, Shohreh

“…CpG oligodeoxynucleotides (CpG-ODN) are capable of inducing high amounts of type I IFNs with many immunomodulatory properties. Furthermore, type-I IFNs have…”
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Neuron-mediated generation of regulatory T cells from encephalitogenic T cells suppresses EAE by Issazadeh-Navikas, Shohreh, Liu, Yawei, Teige, Ingrid, Birnir, Bryndis

“…Neurons have been neglected as cells with a major immune-regulatory function because they do not express major histocompatibility complex class II. Our data…”
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Antibodies to Costimulatory Receptor 4-1BB Enhance Anti-tumor Immunity via T Regulatory Cell Depletion and Promotion of CD8 T Cell Effector Function by Buchan, Sarah L., Dou, Lang, Remer, Marcus, Booth, Steven G., Dunn, Stuart N., Lai, Chester, Semmrich, Monika, Teige, Ingrid, Mårtensson, Linda, Penfold, Christine A., Chan, H.T. Claude, Willoughby, Jane E., Mockridge, C. Ian, Dahal, Lekh N., Cleary, Kirstie L.S., James, Sonya, Rogel, Anne, Kannisto, Päivi, Jernetz, Mats, Williams, Emily L., Healy, Eugene, Verbeek, J. Sjef, Johnson, Peter W.M., Frendéus, Björn, Cragg, Mark S., Glennie, Martin J., Gray, Juliet C., Al-Shamkhani, Aymen, Beers, Stephen A.

“…The costimulatory receptor 4-1BB is expressed on activated immune cells, including activated T cells. Antibodies targeting 4-1BB enhance the proliferation and…”
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Abstract 1642: A novel FcγRIIB-blocking antibody to enhance FcγR-dependent antitumor immunity by Mårtensson, Linda, Oldham, Robert, Borggren, Marie, Kovacek, Mathilda, Blidberg, Therese, Roghanian, Ali, Thornberg, Ulla-Carin, Karlsson, Ingrid, Beers, Stephen A., Cragg, Mark S., Teige, Ingrid, Frendéus, Bjorn L.

“…Abstract Therapeutic antibodies have improved survival of both hematologic and solid cancer patients, inducing long-lasting responses and even cures…”
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