Search Results - "Teichert, W."

Insights into the origins of fish hunting in venomous cone snails from studies of Conus tessulatus by Aman, Joseph W., Imperial, Julita S., Ueberheide, Beatrix, Zhang, Min-Min, Aguilar, Manuel, Taylor, Dylan, Watkins, Maren, Yoshikami, Doju, Showers-Corneli, Patrice, Safavi-Hemami, Helena, Biggs, Jason, Teichert, Russell W., Olivera, Baldomero M.

“…Significance Only rarely is it possible to reconstruct molecular events that trigger the radiation of new lineages. Here we report key evidence that allows…”
Get full text

Using constellation pharmacology to define comprehensively a somatosensory neuronal subclass by Teichert, Russell W., Memon, Tosifa, Aman, Joseph W., Olivera, Baldomero M.

“…Change is intrinsic to nervous systems; change is required for learning and conditioning and occurs with disease progression, normal development, and aging. To…”
Get full text

Characterization of two neuronal subclasses through constellation pharmacology by Teichert, Russell W, Raghuraman, Shrinivasan, Memon, Tosifa, Cox, Jeffrey L, Foulkes, Tucker, Rivier, Jean E, Olivera, Baldomero M

“…Different types of neurons diverge in function because they express their own unique set or constellation of signaling molecules, including receptors and ion…”
Get full text

Functional profiling of neurons through cellular neuropharmacology by Teichert, Russell W, Smith, Nathan J, Raghuraman, Shrinivasan, Yoshikami, Doju, Light, Alan R, Olivera, Baldomero M

“…We describe a functional profiling strategy to identify and characterize subtypes of neurons present in a peripheral ganglion, which should be extendable to…”
Get full text

Diversity of the neurotoxic Conus peptides: a model for concerted pharmacological discovery by Olivera, Baldomero M, Teichert, Russell W

“…Predatory cone snails (genus Conus) produce a rich array of venoms that collectively contain an estimated 100,000 small, disulfide-rich peptides (i.e.,…”
Get full text

Comparative functional expression of nAChR subtypes in rodent DRG neurons by Smith, Nathan J, Hone, Arik J, Memon, Tosifa, Bossi, Simon, Smith, Thomas E, McIntosh, J Michael, Olivera, Baldomero M, Teichert, Russell W

“…We investigated the functional expression of nicotinic acetylcholine receptors (nAChRs) in heterogeneous populations of dissociated rat and mouse lumbar dorsal…”
Get full text

Defining modulatory inputs into CNS neuronal subclasses by functional pharmacological profiling by Raghuraman, Shrinivasan, Garcia, Alfredo J., Anderson, Tatiana M., Twede, Vernon D., Curtice, Kigen J., Chase, Kevin, Ramirez, Jan-Marino, Olivera, Baldomero M., Teichert, Russell W.

“…Previously we defined neuronal subclasses within the mouse peripheral nervous system using an experimental strategy called “constellation pharmacology.” Here…”
Get full text

αC-Conotoxin PrXA:  A New Family of Nicotinic Acetylcholine Receptor Antagonists by Jimenez, Elsie C, Olivera, Baldomero M, Teichert, Russell W

“…We have purified a novel paralytic peptide with 32 AA and a single disulfide bond from the venom of Conus parius, a fish-hunting species. The peptide has the…”
Get full text

Novel Conantokins from Conus parius Venom Are Specific Antagonists of N-Methyl-D-aspartate Receptors by Teichert, Russell W., Jimenez, Elsie C., Twede, Vernon, Watkins, Maren, Hollmann, Michael, Bulaj, Grzegorz, Olivera, Baldomero M.

“…We report the discovery and characterization of three conantokin peptides from the venom of Conus parius. Each peptide (conantokin-Pr1, -Pr2, and -Pr3)…”
Get full text

Conantokin-P, an unusual conantokin with a long disulfide loop by Gowd, Konkallu Hanumae, Twede, Vernon, Watkins, Maren, Krishnan, K.S., Teichert, Russell W., Bulaj, Grzegorz, Olivera, Baldomero M.

“…The conantokins are a family of Conus venom peptides (17–27AA) that are N-methyl- d-aspartate (NMDA) receptor antagonists. Conantokins lack disulfide bridges…”
Get full text

A novel alpha conotoxin ( α-PIB) isolated from C. purpurascens is selective for skeletal muscle nicotinic acetylcholine receptors by López-Vera, Estuardo, Jacobsen, Richard B., Ellison, Michael, Olivera, Baldomero M., Teichert, Russell W.

“…The α-conotoxin family is comprised of peptides that share the following arrangement of cysteine residues in the primary amino acid sequence: –CC–C–C–, where…”
Get full text

Definition and Characterization of the Short αA-Conotoxins:  A Single Residue Determines Dissociation Kinetics from the Fetal Muscle Nicotinic Acetylcholine Receptor by Teichert, Russell W, López-Vera, Estuardo, Gulyas, Jozsef, Watkins, Maren, Rivier, Jean, Olivera, Baldomero M

“…We report the definition and characterization of a conotoxin subfamily, designated the short αA-conotoxins (αAS) and demonstrate that all of these share the…”
Get full text

αS-Conotoxin RVIIIA:  A Structurally Unique Conotoxin That Broadly Targets Nicotinic Acetylcholine Receptors by Teichert, Russell W, Jimenez, Elsie C, Olivera, Baldomero M

“…We report the purification and characterization of a new conotoxin from the venom of Conus radiatus. The peptide, αS-conotoxin RVIIIA (αS-RVIIIA), is…”
Get full text

trans -Anethole of Fennel Oil is a Selective and Nonelectrophilic Agonist of the TRPA1 Ion Channel by Memon, Tosifa, Yarishkin, Oleg, Reilly, Christopher A, Križaj, David, Olivera, Baldomero M, Teichert, Russell W

“…Transient receptor potential (TRP) cation channels are molecular targets of various natural products. TRPA1, a member of TRP channel family, is specifically…”
Get more information

Reply to Voets et al.: Constellation pharmacology is poised to answer scientific questions by Teichert, Russell W., Olivera, Baldomero M.

Get full text

An integrative approach to the facile functional classification of dorsal root ganglion neuronal subclasses by Giacobassi, Mario J., Leavitt, Lee S., Raghuraman, Shrinivasan, Alluri, Rishi, Chase, Kevin, Finol-Urdaneta, Rocio K., Terlau, Heinrich, Teichert, Russell W., Olivera, Baldomero M.

“…Somatosensory neurons have historically been classified by a variety of approaches, including structural, anatomical, and genetic markers; electrophysiological…”
Get full text

TRPA1 expression levels and excitability brake by KV channels influence cold sensitivity of TRPA1-expressing neurons by Memon, Tosifa, Chase, Kevin, Leavitt, Lee S, Olivera, Baldomero M, Teichert, Russell W

“…Highlights • Three distinct subclasses of sensory neurons mediate cold responses. • Cold responses in TRPA1-expressing neurons depend on TRPA1 and not TRPM8…”
Get full text

Constellation Pharmacology: A New Paradigm for Drug Discovery by Teichert, Russell W, Schmidt, Eric W, Olivera, Baldomero M

“…Constellation pharmacology is a cell-based high-content phenotypic-screening platform that utilizes subtype-selective pharmacological agents to elucidate the…”
Get full text

The rescue of developing avian motoneurons from programmed cell death by a selective inhibitor of the fetal muscle‐specific nicotinic acetylcholine receptor by Oppenheim, Ronald W., Calderó, Jordi, Cuitat, Doloros, Esquerda, Josep, McArdle, Joseph J., Olivera, Baldomero M., Prevette, David, Teichert, Russell W.

“…In an attempt to determine whether the rescue of developing motoneurons (MNS) from programmed cell death (PCD) in the chick embryo following reductions in…”
Get full text

αA-Conotoxin OIVA defines a new αA-conotoxin subfamily of nicotinic acetylcholine receptor inhibitors by Teichert, Russell W., Rivier, Jean, Dykert, John, Cervini, Laura, Gulyas, Jozsef, Bulaj, Grzegorz, Ellison, Michael, Olivera, Baldomero M.

“…The venoms of cone snails are rich in multiply disulfide-crosslinked peptides, the conotoxins. Conotoxins are grouped into families on the basis of shared…”
Get full text