A new benzoquinone and a new stilbenoid from Paphiopedilum exul (Ridl.) Rolfe

One new alkyl benzoquinone, paphionone ( ), one new stilbenoid, ( )-6,5'-dihydroxy-2,3'-dimethoxystilbene ( ), and eight known stilbenoids and flavonoids ( - ) were isolated from the leaves and roots of (Orchidaceae). Their chemical structures were determined based on IR, ECD, MS and NMR a...

Full description

Saved in:

Bibliographic Details
Published in:	Natural product research pp. 1 - 9
Main Authors:	Lertnitikul, Nonthalert, Teerasukpimol, Ladawan, Aekanantakul, Pattatorn, Pooreecharurot, Naphatsawan, Sukrong, Suchada, Boonyong, Cherdsak, Poldorn, Preeyaporn, Rungrotmongkol, Thanyada, Sukandar, Edwin Risky, Aonbangkhen, Chanat, Suttisri, Rutt
Format:	Journal Article
Language:	English
Published:	England 22-04-2024
Subjects:	Paphiopedilum exul benzoquinone stilbenoids flavonoids Orchidaceae cytotoxicity
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	One new alkyl benzoquinone, paphionone ( ), one new stilbenoid, ( )-6,5'-dihydroxy-2,3'-dimethoxystilbene ( ), and eight known stilbenoids and flavonoids ( - ) were isolated from the leaves and roots of (Orchidaceae). Their chemical structures were determined based on IR, ECD, MS and NMR analyses. Cytotoxicity of all isolated compounds towards human hepatocellular carcinoma (HepG2) cell line was examined by MTT assay. The -hydroxybenzyl substituted stilbene was potently cytotoxic to the cancer cells, with an IC value of 4.80 ± 1.10 μM (selectivity index = 20.83). All compounds were non-toxic to normal human embryo fibroblast (OUMS-36) cell line.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1478-6419 1478-6427
DOI:	10.1080/14786419.2024.2344196