Search Results - "Teeguarden, Justin G"

Completing the Link between Exposure Science and Toxicology for Improved Environmental Health Decision Making: The Aggregate Exposure Pathway Framework by Teeguarden, Justin G, Tan, Yu-Mei, Edwards, Stephen W, Leonard, Jeremy A, Anderson, Kim A, Corley, Richard A, Kile, Molly L, Simonich, Staci M, Stone, David, Tanguay, Robert L, Waters, Katrina M, Harper, Stacey L, Williams, David E

“…Driven by major scientific advances in analytical methods, biomonitoring, computation, and a newly articulated vision for a greater impact in public health,…”
Get full text

An integrated approach for the in vitro dosimetry of engineered nanomaterials by Cohen, Joel M, Teeguarden, Justin G, Demokritou, Philip

“…There is a great need for screening tools capable of rapidly assessing nanomaterial toxicity. One impediment to the development of reliable in vitro screening…”
Get full text

Implications of Bioremediation of Polycyclic Aromatic Hydrocarbon-Contaminated Soils for Human Health and Cancer Risk by Davie-Martin, Cleo L., Stratton, Kelly G., Teeguarden, Justin G., Waters, Katrina M., Simonich, Staci L. Massey

“…Bioremediation uses soil microorganisms to degrade polycyclic aromatic hydrocarbons (PAHs) into less toxic compounds and can be performed in situ, without the…”
Get full text

ISiCLE: A Quantum Chemistry Pipeline for Establishing in Silico Collision Cross Section Libraries by Colby, Sean M, Thomas, Dennis G, Nuñez, Jamie R, Baxter, Douglas J, Glaesemann, Kurt R, Brown, Joseph M, Pirrung, Meg A, Govind, Niranjan, Teeguarden, Justin G, Metz, Thomas O, Renslow, Ryan S

“…High-throughput, comprehensive, and confident identifications of metabolites and other chemicals in biological and environmental samples will revolutionize our…”
Get full text

Particokinetics In Vitro: Dosimetry Considerations for In Vitro Nanoparticle Toxicity Assessments by Teeguarden, Justin G., Hinderliter, Paul M., Orr, Galya, Thrall, Brian D., Pounds, Joel G.

“…The rapid growth in the use of in vitro methods for nanoparticle toxicity assessment has proceeded with limited consideration of the unique kinetics of these…”
Get full text

ISDD: A computational model of particle sedimentation, diffusion and target cell dosimetry for in vitro toxicity studies by Hinderliter, Paul M, Minard, Kevin R, Orr, Galya, Chrisler, William B, Thrall, Brian D, Pounds, Joel G, Teeguarden, Justin G

“…The difficulty of directly measuring cellular dose is a significant obstacle to application of target tissue dosimetry for nanoparticle and microparticle…”
Get full text

Twenty-four hour human urine and serum profiles of bisphenol a during high-dietary exposure by Teeguarden, Justin G, Calafat, Antonia M, Ye, Xiaoyum, Doerge, Daniel R, Churchwell, Mona I, Gunawan, Rudy, Graham, Morgan K

“…By virtue of its binding to steroid hormone receptors, bisphenol A (BPA, the unconjugated bioactive monomer) is hypothesized to be estrogenic when present in…”
Get full text

All that is silver is not toxic: silver ion and particle kinetics reveals the role of silver ion aging and dosimetry on the toxicity of silver nanoparticles by Smith, Jordan N, Thomas, Dennis G, Jolley, Hadley, Kodali, Vamsi K, Littke, Matthew H, Munusamy, Prabhakaran, Baer, Donald R, Gaffrey, Matthew J, Thrall, Brian D, Teeguarden, Justin G

“…When suspended in cell culture medium, nano-objects composed of soluble metals such as silver can dissolve resulting in ion formation, altered particle…”
Get full text

ISD3: a particokinetic model for predicting the combined effects of particle sedimentation, diffusion and dissolution on cellular dosimetry for in vitro systems by Thomas, Dennis G, Smith, Jordan N, Thrall, Brian D, Baer, Donald R, Jolley, Hadley, Munusamy, Prabhakaran, Kodali, Vamsi, Demokritou, Philip, Cohen, Joel, Teeguarden, Justin G

“…The development of particokinetic models describing the delivery of insoluble or poorly soluble nanoparticles to cells in liquid cell culture systems has…”
Get full text

Urine and serum biomonitoring of exposure to environmental estrogens II: Soy isoflavones and zearalenone in pregnant women by Fleck, Stefanie C., Churchwell, Mona I., Doerge, Daniel R., Teeguarden, Justin G.

“…Urine and serum biomonitoring was used to measure internal exposure to selected dietary estrogens in a cohort of 30 pregnant women. Exposure was measured over…”
Get full text

24-hour human urine and serum profiles of bisphenol A: Evidence against sublingual absorption following ingestion in soup by Teeguarden, Justin G., Twaddle, Nathan C., Churchwell, Mona I., Yang, Xiaoxia, Fisher, Jeffrey W., Seryak, Liesel M., Doerge, Daniel R.

“…Extensive first-pass metabolism of ingested bisphenol A (BPA) in the gastro-intestinal tract and liver restricts blood concentrations of bioactive BPA to <1%…”
Get full text

Microcystin-LR aerosol induces inflammatory responses in healthy human primary airway epithelium by Breidenbach, Joshua D., French, Benjamin W., Gordon, Tamiya T., Kleinhenz, Andrew L., Khalaf, Fatimah K., Willey, James C., Hammersley, Jeffrey R., Mark Wooten, R., Crawford, Erin L., Modyanov, Nikolai N., Malhotra, Deepak, Teeguarden, Justin G., Haller, Steven T., Kennedy, David J.

“…Harmful algal blooms plague bodies of freshwater globally. These blooms are often composed of outgrowths of cyanobacteria capable of producing the heptapeptide…”
Get full text

Comparative Risks of Aldehyde Constituents in Cigarette Smoke Using Transient Computational Fluid Dynamics/Physiologically Based Pharmacokinetic Models of the Rat and Human Respiratory Tracts by Corley, Richard A, Kabilan, Senthil, Kuprat, Andrew P, Carson, James P, Jacob, Richard E, Minard, Kevin R, Teeguarden, Justin G, Timchalk, Charles, Pipavath, Sudhakar, Glenny, Robb, Einstein, Daniel R

“…Computational fluid dynamics (CFD) modeling is well suited for addressing species-specific anatomy and physiology in calculating respiratory tissue exposures…”
Get full text

An automated framework for NMR chemical shift calculations of small organic molecules by Yesiltepe, Yasemin, Nuñez, Jamie R., Colby, Sean M., Thomas, Dennis G., Borkum, Mark I., Reardon, Patrick N., Washton, Nancy M., Metz, Thomas O., Teeguarden, Justin G., Govind, Niranjan, Renslow, Ryan S.

“…When using nuclear magnetic resonance (NMR) to assist in chemical identification in complex samples, researchers commonly rely on databases for chemical shift…”
Get full text

Comparative proteomics and pulmonary toxicity of instilled single-walled carbon nanotubes, crocidolite asbestos, and ultrafine carbon black in mice by Teeguarden, Justin G, Webb-Robertson, Bobbie-Jo, Waters, Katrina M, Murray, Ashley R, Kisin, Elena R, Varnum, Susan M, Jacobs, Jon M, Pounds, Joel G, Zanger, Richard C, Shvedova, Anna A

“…Reflecting their exceptional potential to advance a range of biomedical, aeronautic, and other industrial products, carbon nanotube (CNT) production and the…”
Get full text

Aerosolized ZnO Nanoparticles Induce Toxicity in Alveolar Type II Epithelial Cells at the Air-Liquid Interface by Xie, Yumei, Williams, Nolann G., Tolic, Ana, Chrisler, William B., Teeguarden, Justin G., Maddux, Bettye L.S., Pounds, Joel G., Laskin, Alexander, Orr, Galya

“…The majority of in vitro studies characterizing the impact of engineered nanoparticles (NPs) on cells that line the respiratory tract were conducted in cells…”
Get full text

A systematic review of Bisphenol A “low dose” studies in the context of human exposure: A case for establishing standards for reporting “low-dose” effects of chemicals by Teeguarden, Justin G., Hanson-Drury, Sesha

“…[Display omitted] •Human exposure to the estrogenic food contaminant bisphenol A is low, but widespread.•An accumulation of published “low dose” BPA toxicity…”
Get full text

Evaluation of Oral and Intravenous Route Pharmacokinetics, Plasma Protein Binding, and Uterine Tissue Dose Metrics of Bisphenol A: A Physiologically Based Pharmacokinetic Approach by Teeguarden, Justin G., Waechter, John M., Clewell, Harvey J., Covington, Tammie R., Barton, Hugh A.

“…Bisphenol A (BPA) is a weakly estrogenic monomer used in the production of polycarbonate plastic and epoxy resins, both of which are used in food contact and…”
Get full text

Development of a physiologically based pharmacokinetic model for assessment of human exposure to bisphenol A by Yang, Xiaoxia, Doerge, Daniel R., Teeguarden, Justin G., Fisher, Jeffrey W.

“…A previously developed physiologically based pharmacokinetic (PBPK) model for bisphenol A (BPA) in adult rhesus monkeys was modified to characterize the…”
Get full text

24-hour human urine and serum profiles of bisphenol A following ingestion in soup: Individual pharmacokinetic data and emographics by Teeguarden, Justin G., Twaddle, Nathan C., Churchwell, Mona I., Yang, Xiaoxia, Fisher, Jeffrey W., Seryak, Liesel M., Doerge, Daniel R.

“…Here we present data to evaluate potential absorption of Bisphenol A through non-metabolizing tissues of the upper digestive tract. Concurrent serum and urine…”
Get full text