Search Results - "Tedja, Roslyn"

Effects of Serum Adsorption on Cellular Uptake Profile and Consequent Impact of Titanium Dioxide Nanoparticles on Human Lung Cell Lines by Tedja, Roslyn, Lim, May, Amal, Rose, Marquis, Christopher

“…Exposure to fetal bovine serum (FBS) is shown herein to reduce the aggregate size of titanium dioxide (TiO2) nanoparticles, affecting uptake and consequent…”
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CBX7 binds the E-box to inhibit TWIST-1 function and inhibit tumorigenicity and metastatic potential by Li, Juanni, Alvero, Ayesha B., Nuti, Sudhakar, Tedja, Roslyn, Roberts, Cai M., Pitruzzello, Mary, Li, Yimin, Xiao, Qing, Zhang, Sai, Gan, Yaqi, Wu, Xiaoying, Mor, Gil, Yin, Gang

“…Deaths from ovarian cancer usually occur when patients succumb to overwhelmingly numerous and widespread micrometastasis. Whereas epithelial–mesenchymal…”
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Adipose microenvironment promotes hypersialylation of ovarian cancer cells by Fox, Alexandra, Leonard, Garry D, Adzibolosu, Nicholas, Wong, Terrence, Tedja, Roslyn, Sharma, Sapna, Gogoi, Radhika, Morris, Robert, Mor, Gil, Fehl, Charlie, Alvero, Ayesha B

“…Ovarian and other peritoneal cancers have a strong tendency to metastasize into the surrounding adipose tissue. This study describes an effect of the adipose…”
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Immunological modifications following chemotherapy are associated with delayed recurrence of ovarian cancer by Adzibolosu, Nicholas, Alvero, Ayesha B, Ali-Fehmi, Rouba, Gogoi, Radhika, Corey, Logan, Tedja, Roslyn, Chehade, Hussein, Gogoi, Vir, Morris, Robert, Anderson, Matthew, Vitko, Julie, Lam, Clarissa, Craig, Douglas B, Draghici, Sorin, Rutherford, Thomas, Mor, Gil

“…Ovarian cancer recurs in most High Grade Serous Ovarian Cancer (HGSOC) patients, including initial responders, after standard of care. To improve patient…”
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Adipose-derived exosomal miR-421 targets CBX7 and promotes metastatic potential in ovarian cancer cells by Zhang, Yi, Tedja, Roslyn, Millman, Michael, Wong, Terrence, Fox, Alexandra, Chehade, Hussein, Gershater, Meyer, Adzibolosu, Nicholas, Gogoi, Radhika, Anderson, Matthew, Rutherford, Thomas, Zhang, Zhenggang, Chopp, Michael, Mor, Gil, Alvero, Ayesha B

“…Chromobox protein homolog 7 (CBX7), a member of the Polycomb repressor complex, is a potent epigenetic regulator and gene silencer. Our group has previously…”
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MNRR1 is a driver of ovarian cancer progression by Chehade, Hussein, Purandare, Neeraja, Fox, Alexandra, Adzibolosu, Nicholas, Jayee, Shawn, Singh, Aryan, Tedja, Roslyn, Gogoi, Radhika, Aras, Siddhesh, Grossman, Lawrence I., Mor, Gil, Alvero, Ayesha B.

“…•MNRR1 reprograms focal adhesion and extra-cellular matrix in ovarian cancer cells.•MNRR1 is both sufficient and required for spheroid formation in ovarian…”
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Transimmunization restores immune surveillance and prevents recurrence in a syngeneic mouse model of ovarian cancer by Alvero, Ayesha B., Hanlon, Douglas, Pitruzzello, Mary, Filler, Renata, Robinson, Eve, Sobolev, Olga, Tedja, Roslyn, Ventura, Alessandra, Bosenberg, Marcus, Han, Patrick, Edelson, Richard L., Mor, Gil

“…Ovarian cancer accounts for most deaths from gynecologic malignancies. Although more than 80% of patients respond to first-line standard of care, most of these…”
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The Role of Intra-Tumoral Heterogeneity and Its Clinical Relevance in Epithelial Ovarian Cancer Recurrence and Metastasis by Roberts, Cai M, Cardenas, Carlos, Tedja, Roslyn

“…Epithelial ovarian cancer is the deadliest gynecologic cancer, due in large part to recurrent tumors. Recurrences tend to have metastasized, mainly in the…”
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Immunological modifications following chemotherapy are associated with delayed recurrence of ovarian cancer (2295) by Adzibolosu, Nicholas, Alvero, Ayesha, Tedja, Roslyn, Gogoi, Radhika, Morris, Robert, Anderson, Matthew, Draghici, Sorin, Rutherford, Thomas, Mor, Gil

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Loss of MNRR1 inhibits spheroid formation and improves survival in an ovarian cancer mouse syngeneic model (2287) by Chehade, Hussein, Purandare, Neeraja, Fox, Alexandra, Gogoi, Radhika, Tedja, Roslyn, Aras, Siddhesh, Grossman, Lawrence, Mor, Gil, Alvero, Ayesha

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Abstract 2333: EMT programs ovarian cancer cells to survive the adipocyte-rich microenvironment by Chehade, Hussein, Fox, Alexandra, Tedja, Roslyn, Gogoi, Radhika, Mor, Gil, Alvero, Ayesha B.

“…Abstract Background: Metabolic pathways are non-canonical targets of the EMT program. The relevance of re-programming metabolism during the metastasis cascade…”
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Abstract A01: Specific targeting of adipose tissue-associated metastasis using bile salt nanoparticles by Tedja, Roslyn, Alvero, Ayesha B., Lee, Jung Seok, Pitruzzello, Mary, Fahmy, Tarek, Mor, Gil G.

“…Abstract Purpose: Mortality in ovarian cancer occurs in the setting of recurrent disease. Recurrent disease is known to arise from residual disease, which…”
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Adipose-derived exosomal miR-421 induces epigenetic reprogramming in ovarian cancer cells by targeting CBX7 (2291) by Chehade, Hussein, Tedja, Roslyn, Zhang, Yi, Fox, Alexandra, Millman, Michael, Gogoi, Radhika, Anderson, Matthew, Rutherford, Thomas, Zhang, Zheng, Chopp, Michael, Mor, Gil, Alvero, Ayesha

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Loss of connective tissue growth factor expression promotes remodeling of the extracellular matrix and epithelial-to-mesenchymal transition in ovarian cancer (2294) by Alvero, Ayesha, Gogoi, Radhika, Galoforo, Sandra, Morris, Colton, You, Yuan, Ramos, Harry, Fox, Alexandra, Tedja, Roslyn, Adzibolosu, Nicholas, Gogoi, Vir, Shi, Chenjun, Zhang, Jitao, Mor, Gil

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p53-Pirh2 Complex Promotes Twist1 Degradation and Inhibits EMT by Yang-Hartwich, Yang, Tedja, Roslyn, Roberts, Cai M, Goodner-Bingham, Jamie, Cardenas, Carlos, Gurea, Marta, Sumi, Natalia J, Alvero, Ayesha B, Glackin, Carlotta A, Mor, Gil

“…Epithelial-mesenchymal transition (EMT) is a critical process involved in cancer metastasis and chemoresistance. Twist1 is a key EMT-inducing transcription…”
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Protein kinase Cα–mediated phosphorylation of Twist1 at Ser-144 prevents Twist1 ubiquitination and stabilizes it by Tedja, Roslyn, Roberts, Cai M., Alvero, Ayesha B., Cardenas, Carlos, Yang-Hartwich, Yang, Spadinger, Sydney, Pitruzzello, Mary, Yin, Gang, Glackin, Carlotta A., Mor, Gil

“…Twist1 is a basic helix-loop-helix transcription factor that plays a key role in embryonic development, and its expression is down-regulated in adult cells…”
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Abstract TMIM-084: PKCα INDUCES TWIST1 PHOSPHORYLATION AT SERINE 144 AND PROMOTES EMT IN OVARIAN CANCER CELLS by Tedja, Roslyn, Roberts, Cai, Cardenas, Carlos, Alvero, Ayesha B., Pitruzzello, Mary, Yang-Hartwich, Yang, Glackin, Carlotta, Mor, Gil G.

“…Abstract PURPOSE: Metastasis and carcinomatosis remains a major problem in ovarian cancer. Metastasis requires a process known as Epithelial-to-Mesenchymal…”
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Biological impacts of TiO2 on human lung cell lines A549 and H1299: particle size distribution effects by Tedja, Roslyn, Marquis, Christopher, Lim, May, Amal, Rose

“…Increasing use of titanium dioxide (TiO 2 ) nanoparticles in many commercial applications has led to emerging concerns regarding the safety and environmental…”
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Generation of Stable Epithelial-Mesenchymal Hybrid Cancer Cells with Tumorigenic Potential by Tedja, Roslyn, Alvero, Ayesha B, Fox, Alexandra, Cardenas, Carlos, Pitruzzello, Mary, Chehade, Hussein, Bawa, Tejeshwhar, Adzibolosu, Nicholas, Gogoi, Radhika, Mor, Gil

“…Cancer progression, invasiveness, and metastatic potential have been associated with the activation of the cellular development program known as…”
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Abstract A02: CBX7 binds TWIST-1’s E-box to inhibit TWIST-1 function and curtail tumorigenecity and metastatic potential in ovarian cancer by Li, Juanni, Alvero, Ayesha B, Nuti, Sudhakar, Tedja, Roslyn, Roberts, Cai M., Pitruzzello, Mary, Li, Yimin, Xiao, Qing, Zhang, Sai, Gan, Yaqi, Mor, Gil, Yin, Gang

“…Abstract Introduction: Ovarian cancer metastasizes via the transcoelomic route and yields overwhelmingly numerous micrometastases. This clinical presentation…”
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