12-Month Outcomes of Combined Phacoemulsification and iStent Inject in Asian Eyes with Normal Tension Glaucoma: A Single-Centre Experience

12-Month Outcomes of Combined Phacoemulsification and iStent Inject in Asian Eyes with Normal Tension Glaucoma: A Single-Centre Experience

Purpose To evaluate efficacy and safety of the iStent inject combined with phacoemulsification in Asian eyes with normal-tension glaucoma (NTG) up to 12 months after surgery. Study design Retrospective case series. Methods Retrospective case series of eyes undergoing surgery from April 2017 to Augus...

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Bibliographic Details
Published in:International ophthalmology Vol. 42; no. 2; pp. 611 - 620
Main Authors: Ang, Bryan C. H., Tecson, Ivan C. R. O’Neill, Hu, Jeremy Y. W., Kan, John T. C., Yip, Leonard W. L.
Format: Journal Article
Language:English
Published: Dordrecht Springer Netherlands 01-02-2022
Springer Nature B.V
Subjects:
Aged
Aged, 80 and over
Complications
Eye
Eye (anatomy)
Eye surgery
Female
Glaucoma
Glaucoma, Open-Angle - surgery
Humans
Intraocular Pressure
Low Tension Glaucoma - surgery
Male
Medicine
Medicine & Public Health
Ophthalmology
Original Paper
Phacoemulsification
Retrospective Studies
Stents
Subgroups
Surgery
Surgical outcomes
Trabecular Meshwork - surgery
Glaucoma
Normal tension glaucoma
iStent inject
Asian
Minimally invasive glaucoma surgery
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Summary:Purpose To evaluate efficacy and safety of the iStent inject combined with phacoemulsification in Asian eyes with normal-tension glaucoma (NTG) up to 12 months after surgery. Study design Retrospective case series. Methods Retrospective case series of eyes undergoing surgery from April 2017 to August 2019. Outcome measures included intraocular pressure (IOP), number of topical glaucoma medications and adverse outcomes. Data were retrieved from the post-operative day 1 (POD1), week 1 (POW1), month 1 (POM1), month 3 (POM3), month 6 (POM6) and month 12 (POM12) timepoints. Data were analysed at each timepoint for eyes with available clinical data at that visit. Subgroup analysis was performed for a consistent cohort which included only eyes with data at all six follow-up timepoints. Results Data from 91 eyes in the collective subject group was analysed. Majority of subjects were male (53, 58.2%) and Chinese (79, 86.8%). Mean age was 73.2 ± 7.2 years. Pre-operatively, mean IOP was 14.3 ± 3.0 mmHg and mean number of medications was 1.5 ± 0.8. Significant IOP reduction was observed at all timepoints except POW1 and POM12. The number of medications was reduced at all timepoints ( p  < 0.001). By POM12, there was reduction of 1.2 ± 1.0 medications ( p  < 0.001). Both the collective and consistent cohorts demonstrated a trend towards decreasing surgical efficacy with time, in IOP reduction and decrease in medications. None of the eyes experienced sight-threatening complications. Conclusions Asian eyes with NTG undergoing combined phacoemulsification and iStent inject surgery demonstrated significant and sustained reduction in number of glaucoma medications up to 12 months post-operatively.
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ISSN:0165-5701
1573-2630
DOI:10.1007/s10792-021-02033-3