Search Results - "Techner, José‐Marc"
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Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal
Published in Nature cell biology (01-06-2016)“…Haematopoietic stem cells (HSCs) maintain lifelong blood production and increase blood cell numbers in response to chronic and acute injury. However, the…”
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A novel treatment for skin repair using a combination of spironolactone and vitamin D3
Published in Annals of the New York Academy of Sciences (01-11-2020)“…Injury of the skin from exposure to toxic chemicals leads to the release of inflammatory mediators and the recruitment of immune cells. Nitrogen mustard (NM)…”
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High-Throughput Synthesis and Analysis of Intact Glycoproteins Using SAMDI-MS
Published in Analytical chemistry (Washington) (21-01-2020)“…High-throughput quantification of the post-translational modification of many individual protein samples is challenging with current label-based methods. This…”
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Skin Tape Strip Proteomics in Mycosis Fungoides Identifies Tumor-Associated Biomarkers
Published in Journal of investigative dermatology (01-03-2023)Get full text
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Vitamin D3 and deconvoluting a rash
Published in JCI insight (24-01-2023)“…BACKGROUNDAdverse drug reactions are unpredictable immunologic events presenting frequent challenges to clinical management. Systemically administered…”
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Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons
Published in The Journal of experimental medicine (10-02-2014)“…Type I interferons (IFN-1s) are antiviral cytokines that suppress blood production while paradoxically inducing hematopoietic stem cell (HSC) proliferation…”
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High-Throughput Development of Glycosyltransferase Assays Using SAMDI-MS
Published 01-01-2019“…More than half of proteins in humans are modified with carbohydrates in a process called glycosylation, yet this process remains poorly understood even though…”
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Dissertation -
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Chronic interleukin-1 drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal
Published in Nature cell biology (25-04-2016)“…Haematopoietic stem cells (HSC) maintain lifelong blood production and increase blood cell numbers in response to chronic and acute injury. However, the…”
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Journal Article -
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Small Molecule Modulation of Zinc‐Finger Sequence Specificity
Published in The FASEB journal (01-04-2011)“…The high resolution x‐ray crystal structure of Aart, a synthetic six finger zinc‐finger protein, bound to DNA revealed the presence of glycerol molecules at…”
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Interleukin-1 Drives Precocious Myeloid Differentiation of Hematopoietic Stem Cells at the Expense of Self-Renewal
Published in Blood (03-12-2015)“…Hematopoietic stem cells (HSCs) maintain lifelong blood homeostasis. While many of the cell-intrinsic mechanisms regulating HSC function at steady state have…”
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The PRO-inflammatory cytokine interleukin-1 is a key regulator of hematopoietic Stem cell fate and function
Published in Experimental hematology (01-09-2016)Get full text
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198: Interleukin-1 drives hematopoietic stem cell differentiation and myelopoiesis via a Pu.1-dependent molecular program
Published in Cytokine (Philadelphia, Pa.) (01-09-2013)“…Hematopoietic stem cells (HSCs) are a rare population of self-renewing bone marrow (BM) cells that give rise to all lineages of mature blood cells including…”
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Journal Article