Search Results - "Technau, Gerhard M."
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Progressive derivation of serially homologous neuroblast lineages in the gnathal CNS of Drosophila
Published in PloS one (07-02-2018)“…Along the anterior-posterior axis the central nervous system is subdivided into segmental units (neuromeres) the composition of which is adapted to their…”
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The commonly used marker ELAV is transiently expressed in neuroblasts and glial cells in the Drosophila embryonic CNS
Published in Developmental dynamics (01-12-2007)“…Glial cells in the Drosophila embryonic nervous system can be monitored with the marker Reversed‐polarity (Repo), whereas neurons lack Repo and express the…”
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3
Cell-Autonomous and Non-cell-autonomous Function of Hox Genes Specify Segmental Neuroblast Identity in the Gnathal Region of the Embryonic CNS in Drosophila
Published in PLoS genetics (25-03-2016)“…During central nervous system (CNS) development neural stem cells (Neuroblasts, NBs) have to acquire an identity appropriate to their location. In thoracic and…”
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Antagonistic roles for Ultrabithorax and Antennapedia in regulating segment-specific apoptosis of differentiated motoneurons in the Drosophila embryonic central nervous system
Published in Development (Cambridge) (15-10-2008)“…The generation of morphological diversity among segmental units of the nervous system is crucial for correct matching of neurons with their targets and for…”
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Molecular markers for identified neuroblasts in the developing brain of Drosophila
Published in Development (Cambridge) (01-08-2003)“…The Drosophila brain develops from the procephalic neurogenic region of the ectoderm. About 100 neural precursor cells (neuroblasts) delaminate from this…”
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Programmed cell death in the embryonic central nervous system of Drosophila melanogaster
Published in Development (Cambridge) (01-01-2007)“…Although programmed cell death (PCD) plays a crucial role throughout Drosophila CNS development, its pattern and incidence remain largely uninvestigated. We…”
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7
Neuroblast formation and patterning during early brain development in Drosophila
Published in BioEssays (01-07-2004)“…The Drosophila embryo provides a useful model system to study the mechanisms that lead to pattern and cell diversity in the central nervous system (CNS). The…”
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8
Generation of cell diversity and segmental pattern in the embryonic central nervous system of Drosophila
Published in Developmental dynamics (01-04-2006)“…Development of the central nervous system (CNS) involves the transformation of a two‐dimensional epithelial sheet of uniform ectodermal cells, the…”
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9
Comm Sorts Robo to Control Axon Guidance at the Drosophila Midline
Published in Cell (23-08-2002)“…Axon growth across the Drosophila midline requires Comm to downregulate Robo, the receptor for the midline repellent Slit. We show here that comm is required…”
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10
Bridging the gap between postembryonic cell lineages and identified embryonic neuroblasts in the ventral nerve cord of Drosophila melanogaster
Published in Biology open (15-04-2015)“…The clarification of complete cell lineages, which are produced by specific stem cells, is fundamental for understanding mechanisms, controlling the generation…”
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The pattern of neuroblast formation, mitotic domains and proneural gene expression during early brain development in Drosophila
Published in Development (Cambridge) (01-08-2003)“…In the Drosophila embryo, studies on CNS development have so far mainly focused on the relatively simply structured ventral nerve cord. In the trunk, proneural…”
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A critical role for Cyclin E in cell fate determination in the central nervous system of Drosophila melanogaster
Published in Nature cell biology (01-01-2005)“…We have examined the process by which cell diversity is generated in neuroblast (NB) lineages in the central nervous system of Drosophila melanogaster…”
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13
Gene expression profiles uncover individual identities of gnathal neuroblasts and serial homologies in the embryonic CNS of Drosophila
Published in Development (Cambridge) (15-04-2016)“…The numbers and types of progeny cells generated by neural stem cells in the developing CNS are adapted to its region-specific functional requirements. In…”
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14
Segment polarity and DV patterning gene expression reveals segmental organization of the Drosophila brain
Published in Development (Cambridge) (15-08-2003)“…The insect brain is traditionally subdivided into the trito-, deuto- and protocerebrum. However, both the neuromeric status and the course of the borders…”
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Multiple roles for Hox genes in segment-specific shaping of CNS lineages
Published in Fly (Austin, Tex.) (01-11-2008)“…In this "Extra View" article we highlight some of the recently accumulating evidence showing that Hox genes are involved at different steps during the…”
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16
Origin of Drosophila mushroom body neuroblasts and generation of divergent embryonic lineages
Published in Development (Cambridge) (01-07-2012)“…Key to understanding the mechanisms that underlie the specification of divergent cell types in the brain is knowledge about the neurectodermal origin and…”
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The Drosophila Hox gene Ultrabithorax acts in both muscles and motoneurons to orchestrate formation of specific neuromuscular connections
Published in Development (Cambridge) (01-01-2017)“…Hox genes are known to specify motoneuron pools in the developing vertebrate spinal cord and to control motoneuronal targeting in several species. However, the…”
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Segment-specific requirements for dorsoventral patterning genes during early brain development in Drosophila
Published in Development (Cambridge) (01-11-2006)“…An initial step in the development of the Drosophila central nervous system is the delamination of a stereotype population of neural stem cells (neuroblasts,…”
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Neuroblast pattern and identity in the Drosophila tail region and role of doublesex in the survival of sex-specific precursors
Published in Development (Cambridge) (01-04-2013)“…The central nervous system is composed of segmental units (neuromeres), the size and complexity of which evolved in correspondence to their functional…”
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Integration of complex larval chemosensory organs into the adult nervous system of Drosophila
Published in Development (Cambridge) (01-01-2004)“…The sense organs of adult Drosophila , and holometabolous insects in general, derive essentially from imaginal discs and hence are adult specific. Experimental…”
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