Search Results - "Tebar, Francesc"

AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation by Herms, Albert, Bosch, Marta, Reddy, Babu J.N., Schieber, Nicole L., Fajardo, Alba, Rupérez, Celia, Fernández-Vidal, Andrea, Ferguson, Charles, Rentero, Carles, Tebar, Francesc, Enrich, Carlos, Parton, Robert G., Gross, Steven P., Pol, Albert

“…Lipid droplets (LDs) are intracellular organelles that provide fatty acids (FAs) to cellular processes including synthesis of membranes and production of…”
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Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains by Kassan, Adam, Herms, Albert, Fernández-Vidal, Andrea, Bosch, Marta, Schieber, Nicole L, Reddy, Babu J N, Fajardo, Alba, Gelabert-Baldrich, Mariona, Tebar, Francesc, Enrich, Carlos, Gross, Steven P, Parton, Robert G, Pol, Albert

“…Control of lipid droplet (LD) nucleation and copy number are critical, yet poorly understood, processes. We use model peptides that shift from the endoplasmic…”
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Annexin A6 modulates TBC1D15/Rab7/StARD3 axis to control endosomal cholesterol export in NPC1 cells by Meneses-Salas, Elsa, García-Melero, Ana, Kanerva, Kristiina, Blanco-Muñoz, Patricia, Morales-Paytuvi, Frederic, Bonjoch, Júlia, Casas, Josefina, Egert, Antonia, Beevi, Syed S., Jose, Jaimy, Llorente-Cortés, Vicenta, Rye, Kerry-Anne, Heeren, Joerg, Lu, Albert, Pol, Albert, Tebar, Francesc, Ikonen, Elina, Grewal, Thomas, Enrich, Carlos, Rentero, Carles

“…Cholesterol accumulation in late endosomes is a prevailing phenotype of Niemann-Pick type C1 (NPC1) mutant cells. Likewise, annexin A6 (AnxA6) overexpression…”
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Annexin A6 and NPC1 regulate LDL-inducible cell migration and distribution of focal adhesions by Jose, Jaimy, Hoque, Monira, Engel, Johanna, Beevi, Syed S., Wahba, Mohamed, Georgieva, Mariya Ilieva, Murphy, Kendelle J., Hughes, William E., Cochran, Blake J., Lu, Albert, Tebar, Francesc, Hoy, Andrew J., Timpson, Paul, Rye, Kerry-Anne, Enrich, Carlos, Rentero, Carles, Grewal, Thomas

“…Cholesterol is considered indispensable for cell motility, but how physiological cholesterol pools enable cells to move forward remains to be clarified. The…”
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A mechanosensing mechanism controls plasma membrane shape homeostasis at the nanoscale by Quiroga, Xarxa, Walani, Nikhil, Disanza, Andrea, Chavero, Albert, Mittens, Alexandra, Tebar, Francesc, Trepat, Xavier, Parton, Robert G, Geli, María Isabel, Scita, Giorgio, Arroyo, Marino, Le Roux, Anabel-Lise, Roca-Cusachs, Pere

“…As cells migrate and experience forces from their surroundings, they constantly undergo mechanical deformations which reshape their plasma membrane (PM). To…”
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Pleiotropic Roles of Calmodulin in the Regulation of KRas and Rac1 GTPases: Functional Diversity in Health and Disease by Tebar, Francesc, Chavero, Albert, Agell, Neus, Lu, Albert, Rentero, Carles, Enrich, Carlos, Grewal, Thomas

“…Calmodulin is a ubiquitous signalling protein that controls many biological processes due to its capacity to interact and/or regulate a large number of…”
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Annexins — Scaffolds modulating PKC localization and signaling by Hoque, Monira, Rentero, Carles, Cairns, Rose, Tebar, Francesc, Enrich, Carlos, Grewal, Thomas

“…Spatial and temporal organization of signal transduction is critical to link different extracellular stimuli with distinct cellular responses. A classical…”
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ROCK1 is a novel Rac1 effector to regulate tubular endocytic membrane formation during clathrin-independent endocytosis by Soriano-Castell, David, Chavero, Albert, Rentero, Carles, Bosch, Marta, Vidal-Quadras, Maite, Pol, Albert, Enrich, Carlos, Tebar, Francesc

“…Clathrin-dependent and -independent pathways contribute for β1-integrin endocytosis. This study defines a tubular membrane clathrin-independent endocytic…”
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Annexin A6 and Late Endosomal Cholesterol Modulate Integrin Recycling and Cell Migration by García-Melero, Ana, Reverter, Meritxell, Hoque, Monira, Meneses-Salas, Elsa, Koese, Meryem, Conway, James R.W., Johnsen, Camilla H., Alvarez-Guaita, Anna, Morales-Paytuvi, Frederic, Elmaghrabi, Yasmin A., Pol, Albert, Tebar, Francesc, Murray, Rachael Z., Timpson, Paul, Enrich, Carlos, Grewal, Thomas, Rentero, Carles

“…Annexins are a family of proteins that bind to phospholipids in a calcium-dependent manner. Earlier studies implicated annexin A6 (AnxA6) to inhibit secretion…”
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Annexins Bridging the Gap: Novel Roles in Membrane Contact Site Formation by Enrich, Carlos, Lu, Albert, Tebar, Francesc, Rentero, Carles, Grewal, Thomas

“…Membrane contact sites (MCS) are specialized small areas of close apposition between two different organelles that have led researchers to reconsider the dogma…”
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clathrin-dependent pathway leads to KRas signaling on late endosomes en route to lysosomes by Lu, Albert, Tebar, Francesc, Alvarez-Moya, Blanca, López-Alcalá, Cristina, Calvo, Maria, Enrich, Carlos, Agell, Neus, Nakamura, Takeshi, Matsuda, Michiyuki, Bachs, Oriol

“…Ras proteins are small guanosine triphosphatases involved in the regulation of important cellular functions such as proliferation, differentiation, and…”
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Caveolin-1 Is Essential for Liver Regeneration by Fernández, Manuel A, Albor, Cecilia, Ingelmo-Torres, Mercedes, Nixon, Susan J, Ferguson, Charles, Kurzchalia, Teymuras, Tebar, Francesc, Enrich, Carlos, Parton, Robert G, Pol, Albert

“…Liver regeneration is an orchestrated cellular response that coordinates cell activation, lipid metabolism, and cell division. We found that caveolin-1…”
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Cholesterol Regulates Syntaxin 6 Trafficking at trans-Golgi Network Endosomal Boundaries by Reverter, Meritxell, Rentero, Carles, Garcia-Melero, Ana, Hoque, Monira, Vilà de Muga, Sandra, Álvarez-Guaita, Anna, Conway, James R.W., Wood, Peta, Cairns, Rose, Lykopoulou, Lilia, Grinberg, Daniel, Vilageliu, Lluïsa, Bosch, Marta, Heeren, Joerg, Blasi, Juan, Timpson, Paul, Pol, Albert, Tebar, Francesc, Murray, Rachael Z., Grewal, Thomas, Enrich, Carlos

“…Inhibition of cholesterol export from late endosomes causes cellular cholesterol imbalance, including cholesterol depletion in the trans-Golgi network (TGN)…”
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Development of an epidermal growth factor derivative with EGFR blocking activity by Panosa, Clara, Tebar, Francesc, Ferrer-Batallé, Montserrat, Fonge, Humphrey, Seno, Masaharu, Reilly, Raymond M, Massaguer, Anna, De Llorens, Rafael

“…The members of the epidermal growth factor (EGF)/ErbB family are prime targets for cancer therapy. However, the therapeutic efficiency of the existing…”
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Dynamics of KRas on endosomes: involvement of acidic phospholipids in its association by Gelabert‐Baldrich, Mariona, Soriano‐Castell, David, Calvo, Maria, Lu, Albert, Viña‐Vilaseca, Arnau, Rentero, Carles, Pol, Albert, Grinstein, Sergio, Enrich, Carlos, Tebar, Francesc

“…ABSTRACT The endocytic compartment is emerging as a functional platform for controlling important cellular processes. We have found that ~10 to 15% of total…”
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Selective Degradation Permits a Feedback Loop Controlling Annexin A6 and Cholesterol Levels in Endolysosomes of NPC1 Mutant Cells by Meneses-Salas, Elsa, García-Melero, Ana, Blanco-Muñoz, Patricia, Jose, Jaimy, Brenner, Marie-Sophie, Lu, Albert, Tebar, Francesc, Grewal, Thomas, Rentero, Carles, Enrich, Carlos

“…We recently identified elevated annexin A6 (AnxA6) protein levels in Niemann-Pick-type C1 (NPC1) mutant cells. In these cells, AnxA6 depletion rescued the…”
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Annexin A6‐Induced Alterations in Cholesterol Transport and Caveolin Export from the Golgi Complex by Cubells, Laia, Vilà de Muga, Sandra, Tebar, Francesc, Wood, Peta, Evans, Rachael, Ingelmo‐Torres, Mercedes, Calvo, Maria, Gaus, Katharina, Pol, Albert, Grewal, Thomas, Enrich, Carlos

“…Annexin A6 (AnxA6) belongs to a family of Ca2+‐dependent membrane‐binding proteins and is involved in the regulation of endocytic and exocytic pathways. We…”
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Annexin A6 stimulates the membrane recruitment of p120GAP to modulate Ras and Raf-1 activity by GREWAL, Thomas, EVANS, Rachael, RINNINGER, Franz, DALY, Roger J, POL, Albert, ENRICH, Carlos, RENTERO, Caries, TEBAR, Francesc, CUBELLS, Laia, DE DIEGO, Inaki, KIRCHHOFF, Matthias F, HUGHES, William E, HEEREN, Joerg, RYE, Kerry-Anne

“…Annexin A6 is a calcium-dependent membrane-binding protein that interacts with signalling proteins, including the GTPase-activating protein p120GAP, one of the…”
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Hydrophobic and Basic Domains Target Proteins to Lipid Droplets by Ingelmo‐Torres, Mercedes, González‐Moreno, Elena, Kassan, Adam, Hanzal‐Bayer, Michael, Tebar, Francesc, Herms, Albert, Grewal, Thomas, Hancock, John F., Enrich, Carlos, Bosch, Marta, Gross, Steven P., Parton, Robert G., Pol, Albert

“…In recent years, progress in the study of the lateral organization of the plasma membrane has led to the proposal that mammalian cells use two different…”
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Rac1 and Calmodulin Interactions Modulate Dynamics of ARF6‐Dependent Endocytosis by Vidal‐Quadras, Maite, Gelabert‐Baldrich, Mariona, Soriano‐Castell, David, Lladó, Anna, Rentero, Carles, Calvo, Maria, Pol, Albert, Enrich, Carlos, Tebar, Francesc

“…The main cellular Ca2+ sensor, calmodulin (CaM), interacts with and regulates several small GTPases, including Rac1. The present study revealed high binding…”
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