Search Results - "Te Kronnie, Geertruy"

Clinical Utility of Microarray-Based Gene Expression Profiling in the Diagnosis and Subclassification of Leukemia: Report From the International Microarray Innovations in Leukemia Study Group by HAFERLACH, Torsten, KOHLMANN, Alexander, GILKES, Amanda, CHIARETTI, Sabina, SHURTLEFF, Sheila A, KIPPS, Thomas J, RASSENTI, Laura Z, YEOH, Allen E, PAPENHAUSEN, Peter R, LIU, Wei-Min, WILLIAMS, P. Mickey, FOA, Robin, WIECZOREK, Lothar, BASSO, Giuseppe, TE KRONNIE, Geertruy, BONO, Marie-Christine, DE VOS, John, HERNINDEZ, Jesus M, HOFMANN, Wolf-Karsten, MILLS, Ken I

“…The Microarray Innovations in Leukemia study assessed the clinical utility of gene expression profiling as a single test to subtype leukemias into conventional…”
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Pro‐inflammatory cytokines favor the emergence of ETV6‐RUNX1‐positive pre‐leukemic cells in a model of mesenchymal niche by Beneforti, Linda, Dander, Erica, Bresolin, Silvia, Bueno, Clara, Acunzo, Denise, Bertagna, Mayla, Ford, Anthony, Gentner, Bernhard, Kronnie, Geertruy te, Vergani, Patrizia, Menéndez, Pablo, Biondi, Andrea, D’Amico, Giovanna, Palmi, Chiara, Cazzaniga, Giovanni

“…Summary ETV6‐RUNX1 (E/R) fusion gene, arising in utero from translocation t(12;21)(p13:q22), is the most frequent alteration in childhood acute lymphoblastic…”
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Therapeutic targeting of mutant p53 in pediatric acute lymphoblastic leukemia by Demir, Salih, Boldrin, Elena, Sun, Qian, Hampp, Stephanie, Tausch, Eugen, Eckert, Cornelia, Ebinger, Martin, Handgretinger, Rupert, Kronnie, Geertruy Te, Wiesmüller, Lisa, Stilgenbauer, Stephan, Selivanova, Galina, Debatin, Klaus-Michael, Meyer, Lüder Hinrich

“…Alterations of the tumor suppressor gene are found in different cancers, in particular in carcinomas of adults. In pediatric acute lymphoblastic leukemia…”
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Suppressors and activators of JAK-STAT signaling at diagnosis and relapse of acute lymphoblastic leukemia in Down syndrome by Schwartzman, Omer, Savino, Angela Maria, Gombert, Michael, Palmi, Chiara, Cario, Gunnar, Schrappe, Martin, Eckert, Cornelia, von Stackelberg, Arend, Huang, Jin-Yan, Hameiri-Grossman, Michal, Avigad, Smadar, te Kronnie, Geertruy, Geron, Ifat, Birger, Yehudit, Rein, Avigail, Zarfati, Giulia, Fischer, Ute, Mukamel, Zohar, Stanulla, Martin, Biondi, Andrea, Cazzaniga, Giovanni, Vetere, Amedeo, Wagner, Bridget K., Chen, Zhu, Chen, Sai-Juan, Tanay, Amos, Borkhardt, Arndt, Izraeli, Shai

“…Children with Down syndrome (DS) are prone to development of high-risk B-cell precursor ALL (DS-ALL), which differs genetically from most sporadic pediatric…”
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Clinico-biological features of 5202 patients with acute lymphoblastic leukemia enrolled in the Italian AIEOP and GIMEMA protocols and stratified in age cohorts by Chiaretti, Sabina, Vitale, Antonella, Cazzaniga, Gianni, Orlando, Sonia Maria, Silvestri, Daniela, Fazi, Paola, Valsecchi, Maria Grazia, Elia, Loredana, Testi, Anna Maria, Mancini, Francesca, Conter, Valentino, te Kronnie, Geertruy, Ferrara, Felicetto, Di Raimondo, Francesco, Tedeschi, Alessandra, Fioritoni, Giuseppe, Fabbiano, Francesco, Meloni, Giovanna, Specchia, Giorgina, Pizzolo, Giovanni, Mandelli, Franco, Guarini, Anna, Basso, Giuseppe, Biondi, Andrea, Foà, Robin

“…The outcome of children and adults with acute lymphoblastic leukemia is markedly different. Since there is limited information on the distribution of…”
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Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation by Lane, Andrew A, Chapuy, Bjoern, Lin, Charles Y, Tivey, Trevor, Li, Hubo, Townsend, Elizabeth C, van Bodegom, Diederik, Day, Tovah A, Wu, Shuo-Chieh, Liu, Huiyun, Yoda, Akinori, Alexe, Gabriela, Schinzel, Anna C, Sullivan, Timothy J, Malinge, Sébastien, Taylor, Jordan E, Stegmaier, Kimberly, Jaffe, Jacob D, Bustin, Michael, te Kronnie, Geertruy, Izraeli, Shai, Harris, Marian H, Stevenson, Kristen E, Neuberg, Donna, Silverman, Lewis B, Sallan, Stephen E, Bradner, James E, Hahn, William C, Crispino, John D, Pellman, David, Weinstock, David M

“…David Weinstock and colleagues identify a triplication at chromosome 21q22 that is associated with development of B cell acute lymphoblastic leukemia (B-ALL)…”
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ActivinA: a new leukemia-promoting factor conferring migratory advantage to B-cell precursor-acute lymphoblastic leukemic cells by Portale, Federica, Cricrì, Giulia, Bresolin, Silvia, Lupi, Monica, Gaspari, Stefania, Silvestri, Daniela, Russo, Barbara, Marino, Noemi, Ubezio, Paolo, Pagni, Fabio, Vergani, Patrizia, Kronnie, Geertruy Te, Valsecchi, Maria Grazia, Locatelli, Franco, Rizzari, Carmelo, Biondi, Andrea, Dander, Erica, D'Amico, Giovanna

“…B-cell precursor-acute lymphoblastic leukemia modulates the bone marrow (BM) niche to become leukemia-supporting and chemo-protective by reprogramming the…”
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Antileukemic Efficacy of BET Inhibitor in a Preclinical Mouse Model of MLL-AF4 + Infant ALL by Bardini, Michela, Trentin, Luca, Rizzo, Francesca, Vieri, Margherita, Savino, Angela M, Garrido Castro, Patricia, Fazio, Grazia, Van Roon, Eddy H J, Kerstjens, Mark, Smithers, Nicholas, Prinjha, Rab K, Te Kronnie, Geertruy, Basso, Giuseppe, Stam, Ronald W, Pieters, Rob, Biondi, Andrea, Cazzaniga, Gianni

“…-rearranged acute lymphoblastic leukemia (ALL) occurring in infants is a rare but very aggressive leukemia, typically associated with a dismal prognosis…”
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Array-based comparative genomic hybridization analysis reveals chromosomal copy number aberrations associated with clinical outcome in canine diffuse large B-cell lymphoma by Aricò, Arianna, Ferraresso, Serena, Bresolin, Silvia, Marconato, Laura, Comazzi, Stefano, Te Kronnie, Geertruy, Aresu, Luca

“…Canine Diffuse Large B-cell Lymphoma (cDLBCL) is an aggressive cancer with variable clinical response. Despite recent attempts by gene expression profiling to…”
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What is the relevance of Ikaros gene deletions as a prognostic marker in pediatric Philadelphia-negative B-cell precursor acute lymphoblastic leukemia? by Palmi, Chiara, Valsecchi, Maria Grazia, Longinotti, Giulia, Silvestri, Daniela, Carrino, Valentina, Conter, Valentino, Basso, Giuseppe, Biondi, Andrea, Kronnie, Geertruy Te, Cazzaniga, Giovanni

“…New prognostic markers are needed for upfront identification of patients with acute lymphocytic leukemia with a high risk of relapse or who are not likely to…”
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CirComPara: A Multi-Method Comparative Bioinformatics Pipeline to Detect and Study circRNAs from RNA-seq Data by Gaffo, Enrico, Bonizzato, Annagiulia, Kronnie, Geertruy Te, Bortoluzzi, Stefania

“…Circular RNAs (circRNAs) are generated by backsplicing of immature RNA forming covalently closed loops of intron/exon RNA molecules. Pervasiveness,…”
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Epigenetic silencing of TFPI-2 in canine diffuse large B-cell lymphoma by Ferraresso, Serena, Bresolin, Silvia, Aricò, Arianna, Comazzi, Stefano, Gelain, Maria Elena, Riondato, Fulvio, Bargelloni, Luca, Marconato, Laura, Kronnie, Geertruy te, Aresu, Luca

“…Epigenetic modifications are important early events during carcinogenesis. In particular, hypermethylation of CpG islands in the promoter region of tumor…”
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Gene Expression–Based Classification As an Independent Predictor of Clinical Outcome in Juvenile Myelomonocytic Leukemia by BRESOLIN, Silvia, ZECCA, Marco, TE KRONNIE, Geertruy, LOCATELLI, Franco, BASSO, Giuseppe, FLOTHO, Christian, TRENTIN, Luca, ZANGRANDO, Andrea, SAINATI, Laura, STARY, Jan, DE MOERLOOSE, Barbara, HASLE, Henrik, NIEMEYER, Charlotte M

“…PURPOSE Juvenile myelomonocytic leukemia (JMML) is a rare early childhood myelodysplastic/myeloproliferative disorder characterized by an aggressive clinical…”
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Antibodies covalently immobilized on actin filaments for fast myosin driven analyte transport by Kumar, Saroj, ten Siethoff, Lasse, Persson, Malin, Lard, Mercy, te Kronnie, Geertruy, Linke, Heiner, Månsson, Alf

“…Biosensors would benefit from further miniaturization, increased detection rate and independence from external pumps and other bulky equipment. Whereas…”
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Functional protein network activation mapping reveals new potential molecular drug targets for poor prognosis pediatric BCP-ALL by Accordi, Benedetta, Espina, Virginia, Giordan, Marco, VanMeter, Amy, Milani, Gloria, Galla, Luisa, Ruzzene, Maria, Sciro, Manuela, Trentin, Luca, De Maria, Ruggero, te Kronnie, Geertruy, Petricoin, Emanuel, Liotta, Lance, Basso, Giuseppe

“…In spite of leukemia therapy improvements obtained over the last decades, therapy is not yet effective in all cases. Current approaches in Acute Lymphoblastic…”
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Molecular Mechanisms of HIF-1α Modulation Induced by Oxygen Tension and BMP2 in Glioblastoma Derived Cells by Pistollato, Francesca, Rampazzo, Elena, Abbadi, Sara, Della Puppa, Alessandro, Scienza, Renato, D'Avella, Domenico, Denaro, Luca, te Kronnie, Geertruy, Panchision, David M., Basso, Giuseppe

“…Background Glioblastoma multiforme (GBM) is one of most common and still poorly treated primary brain tumors. In search for new therapeutic approaches, Bone…”
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MLL rearrangements in pediatric acute lymphoblastic and myeloblastic leukemias: MLL specific and lineage specific signatures by Zangrando, Andrea, Dell'orto, Marta Campo, Te Kronnie, Geertruy, Basso, Giuseppe

“…The presence of MLL rearrangements in acute leukemia results in a complex number of biological modifications that still remain largely unexplained. Armstrong…”
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Germline Genetic IKZF1 Variation and Predisposition to Childhood Acute Lymphoblastic Leukemia by Churchman, Michelle L., Qian, Maoxiang, te Kronnie, Geertruy, Zhang, Ranran, Yang, Wenjian, Zhang, Hui, Lana, Tobia, Tedrick, Paige, Baskin, Rebekah, Verbist, Katherine, Peters, Jennifer L., Devidas, Meenakshi, Larsen, Eric, Moore, Ian M., Gu, Zhaohui, Qu, Chunxu, Yoshihara, Hiroki, Porter, Shaina N., Pruett-Miller, Shondra M., Wu, Gang, Raetz, Elizabeth, Martin, Paul L., Bowman, W. Paul, Winick, Naomi, Mardis, Elaine, Fulton, Robert, Stanulla, Martin, Evans, William E., Relling, Mary V., Pui, Ching-Hon, Hunger, Stephen P., Loh, Mignon L., Handgretinger, Rupert, Nichols, Kim E., Yang, Jun J., Mullighan, Charles G.

“…Somatic genetic alterations of IKZF1, which encodes the lymphoid transcription factor IKAROS, are common in high-risk B-progenitor acute lymphoblastic leukemia…”
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Gain-of-function mutations in interleukin-7 receptor-α (IL7R) in childhood acute lymphoblastic leukemias by Shochat, Chen, Tal, Noa, Bandapalli, Obul R, Palmi, Chiara, Ganmore, Ithamar, te Kronnie, Geertruy, Cario, Gunnar, Cazzaniga, Giovanni, Kulozik, Andreas E, Stanulla, Martin, Schrappe, Martin, Biondi, Andrea, Basso, Giuseppe, Bercovich, Dani, Muckenthaler, Martina U, Izraeli, Shai

“…Interleukin-7 receptor α (IL7R) is required for normal lymphoid development. Loss-of-function mutations in this gene cause autosomal recessive severe combined…”
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DNA methyltransferase 3a hot-spot locus is not mutated in pediatric patients affected by acute myeloid or T-cell acute lymphoblastic leukemia: an Italian study by Paganin, Maddalena, Pigazzi, Martina, Bresolin, Silvia, Masetti, Riccardo, Fagioli, Franca, Chiaretti, Sabina, Cazzaniga, Giovanni, Locatelli, Franco, Pession, Andrea, te Kronnie, Geertruy, Basso, Giuseppe

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