Search Results - "Tchougounova, E"

Loss of Arf causes tumor progression of PDGFB-induced oligodendroglioma by TCHOUGOUNOVA, E, KASTEMAR, M, BRASÄTER, D, HOLLAND, E. C, WESTERMARK, B, UHRBOM, L

“…In a subset of gliomas, the platelet-derived growth factor (PDGF) signaling pathway is perturbed. This is usually an early event occurring in low-grade tumors…”
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Sox5 can suppress platelet-derived growth factor B-induced glioma development in Ink4a-deficient mice through induction of acute cellular senescence by Tchougounova, E, Jiang, Y, Bråsäter, D, Lindberg, N, Kastemar, M, Asplund, A, Westermark, B, Uhrbom, L

“…SOX5 is a member of the high-mobility group superfamily of architectural non-histone proteins involved in gene regulation and maintenance of chromatin…”
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PROX1 is a novel pathway-specific prognostic biomarker for high-grade astrocytomas; results from independent glioblastoma cohorts stratified by age and IDH mutation status by Roodakker, Kenney R, Elsir, Tamador, Edqvist, Per-Henrik D, Hägerstrand, Daniel, Carlson, Joseph, Lysiak, Malgorzata, Henriksson, Roger, Pontén, Fredrik, Rosell, Johan, Söderkvist, Peter, Stupp, Roger, Tchougounova, Elena, Nistér, Monica, Malmström, Annika, Smits, Anja

“…PROX1 is a transcription factor with an essential role in embryonic development and determination of cell fate. In addition, PROX1 has been ascribed…”
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Regulation of extravascular coagulation and fibrinolysis by heparin‐dependent mast cell chymase by Tchougounova, Elena, Pejler, Gunnar

“…ABSTRACT We recently characterized a heparin‐deficient mouse strain generated by targeting the gene for N‐deacetylase/N‐sulfotransferase‐2 (NDST‐2). The…”
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A Key Role for Mast Cell Chymase in the Activation of Pro-matrix Metalloprotease-9 and Pro-matrix Metalloprotease-2 by Tchougounova, Elena, Lundequist, Anders, Fajardo, Ignacio, Winberg, Jan-Olof, Åbrink, Magnus, Pejler, Gunnar

“…Chymases, serine proteases exclusively expressed by mast cells, have been implicated in various pathological conditions. However, the basis for these…”
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The chymase, mouse mast cell protease 4, constitutes the major chymotrypsin-like activity in peritoneum and ear tissue. A role for mouse mast cell protease 4 in thrombin regulation and fibronectin turnover by Tchougounova, Elena, Pejler, Gunnar, Abrink, Magnus

“…To gain insight into the biological role of mast cell chymase we have generated a mouse strain with a targeted deletion in the gene for mast cell protease 4…”
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FGF2 as a potential prognostic biomarker for proneural glioma patients by Sooman, Linda, Freyhult, Eva, Jaiswal, Archita, Navani, Sanjay, Edqvist, Per-Henrik, Pontén, Fredrik, Tchougounova, Elena, Smits, Anja, Elsir, Tamador, Gullbo, Joachim, Lennartsson, Johan, Bergqvist, Michael, Ekman, Simon

“…The survival of high-grade glioma patients is poor and the treatment of these patients can cause severe side effects. This fosters the necessity to identify…”
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Mice lacking histidine decarboxylase exhibit abnormal mast cells by Ohtsu, Hiroshi, Tanaka, Satoshi, Terui, Tadashi, Hori, Yoshio, Makabe-Kobayashi, Yoko, Pejler, Gunnar, Tchougounova, Elena, Hellman, Lars, Gertsenstein, Marina, Hirasawa, Noriyasu, Sakurai, Eiko, Buzás, Edit, Kovács, Péter, Csaba, György, Kittel, Ágnes, Okada, Mikiko, Hara, Masahiro, Mar, Lynn, Numayama-Tsuruta, Keiko, Ishigaki-Suzuki, Satsuki, Ohuchi, Kazuo, Ichikawa, Atsushi, Falus, András, Watanabe, Takehiko, Nagy, András

“…Histidine decarboxylase (HDC) synthesizes histamine from histidine in mammals. To evaluate the role of histamine, we generated HDC-deficient mice using a gene…”
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Glioma-derived macrophage migration inhibitory factor (MIF) promotes mast cell recruitment in a STAT5-dependent manner by Põlajeva, Jelena, Bergström, Tobias, Edqvist, Per-Henrik, Lundequist, Anders, Sjösten, Anna, Nilsson, Gunnar, Smits, Anja, Bergqvist, Michael, Pontén, Fredrik, Westermark, Bengt, Pejler, Gunnar, Forsberg Nilsson, Karin, Tchougounova, Elena

“…Recently, glioma research has increased its focus on the diverse types of cells present in brain tumors. We observed previously that gliomas are associated…”
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Cooperation between Mast Cell Carboxypeptidase A and the Chymase Mouse Mast Cell Protease 4 in the Formation and Degradation of Angiotensin II by Lundequist, Anders, Tchougounova, Elena, Abrink, Magnus, Pejler, Gunnar

“…The octapeptide angiotensin II (Ang II) exerts a wide range of effects on the cardiovascular system but has also been implicated in the regulation of cell…”
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Altered processing of fibronectin in mice lacking heparin. a role for heparin-dependent mast cell chymase in fibronectin degradation by Tchougounova, E, Forsberg, E, Angelborg, G, Kjéllen, L, Pejler, G

“…We have previously generated a mouse strain with a defect in its heparin biosynthesis by targeting the gene for N-deacetylase/N-sulfotransferase-2 (NDST-2)…”
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