Search Results - "Tchorz, Jan"

Prometheus 2.0: drug-induced liver regeneration arising by Tchorz, Jan S.

Get full text

Retuning hepatocytes improves their functional engraftment by Tchorz, Jan S.

Get full text

The RSPO‐LGR4/5‐ZNRF3/RNF43 module in liver homeostasis, regeneration, and disease by Annunziato, Stefano, Sun, Tianliang, Tchorz, Jan S.

“…WNT/β‐catenin signaling plays pivotal roles during liver development, homeostasis, and regeneration. Likewise, its deregulation disturbs metabolic liver…”
Get full text

Spatiotemporal Metabolic Liver Zonation and Consequences on Pathophysiology by Martini, Tomaz, Naef, Felix, Tchorz, Jan S

“…Hepatocytes are the main workers in the hepatic factory, managing metabolism of nutrients and xenobiotics, production and recycling of proteins, and glucose…”
Get full text

Hepatic stellate cells: From bad reputation to mediators of liver homeostasis by Schönberger, Katharina, Tchorz, Jan S

“…Organ size and function critically depend on the tight regulation of cellular turnover. In this issue of Trinh . reveal that hepatic stellate cells play an…”
Get more information

Proliferation tracing reveals regional hepatocyte generation in liver homeostasis and repair by He, Lingjuan, Pu, Wenjuan, Liu, Xiuxiu, Zhang, Zhenqian, Han, Maoying, Li, Yi, Huang, Xiuzhen, Han, Ximeng, Li, Yan, Liu, Kuo, Shi, Mengyang, Lai, Liang, Sun, Ruilin, Wang, Qing-Dong, Ji, Yong, Tchorz, Jan S, Zhou, Bin

“…Organ homeostasis is orchestrated by time- and spatially restricted cell proliferation. Studies identifying cells with superior proliferative capacities often…”
Get full text

Multicellular dynamics of zonal liver regeneration mapped in space and time by Chen, Feng, Tchorz, Jan S

“…In this issue, Ben-Moshe et al. (2022) use spatiotemporally resolved single-cell and spatial transcriptomic profiling to dissect the multicellular dynamics…”
Get full text

USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin by Ji, Lei, Lu, Bo, Zamponi, Raffaella, Charlat, Olga, Aversa, Robert, Yang, Zinger, Sigoillot, Frederic, Zhu, Xiaoping, Hu, Tiancen, Reece-Hoyes, John S., Russ, Carsten, Michaud, Gregory, Tchorz, Jan S., Jiang, Xiaomo, Cong, Feng

“…Axin is a key scaffolding protein responsible for the formation of the β-catenin destruction complex. Stability of Axin protein is regulated by the…”
Get full text

AXIN2+ Pericentral Hepatocytes Have Limited Contributions to Liver Homeostasis and Regeneration by Sun, Tianliang, Pikiolek, Monika, Orsini, Vanessa, Bergling, Sebastian, Holwerda, Sjoerd, Morelli, Lapo, Hoppe, Philipp S., Planas-Paz, Lara, Yang, Yi, Ruffner, Heinz, Bouwmeester, Tewis, Lohmann, Felix, Terracciano, Luigi M., Roma, Guglielmo, Cong, Feng, Tchorz, Jan S.

“…The existence of specialized liver stem cell populations, including AXIN2+ pericentral hepatocytes, that safeguard homeostasis and repair has been…”
Get full text

YAP promotes proliferation, chemoresistance, and angiogenesis in human cholangiocarcinoma through TEAD transcription factors by Marti, Patricia, Stein, Claudia, Blumer, Tanja, Abraham, Yann, Dill, Michael T., Pikiolek, Monika, Orsini, Vanessa, Jurisic, Giorgia, Megel, Philippe, Makowska, Zuzanna, Agarinis, Claudia, Tornillo, Luigi, Bouwmeester, Tewis, Ruffner, Heinz, Bauer, Andreas, Parker, Christian N., Schmelzle, Tobias, Terracciano, Luigi M., Heim, Markus H., Tchorz, Jan S.

“…The Yes‐associated protein (YAP)/Hippo pathway has been implicated in tissue development, regeneration, and tumorigenesis. However, its role in…”
Get full text

Genome-wide screening in human kidney organoids identifies developmental and disease-related aspects of nephrogenesis by Ungricht, Rosemarie, Guibbal, Laure, Lasbennes, Marie-Christine, Orsini, Vanessa, Beibel, Martin, Waldt, Annick, Cuttat, Rachel, Carbone, Walter, Basler, Anne, Roma, Guglielmo, Nigsch, Florian, Tchorz, Jan S., Hoepfner, Dominic, Hoppe, Philipp S.

“…Human organoids allow the study of proliferation, lineage specification, and 3D tissue development. Here we present a genome-wide CRISPR screen in induced…”
Get full text

The Conundrum of the Pericentral Hepatic Niche: WNT/-Catenin Signaling, Metabolic Zonation, and Many Open Questions by Tchorz, Jan S.

“…WNT/-catenin signaling promotes stemness, proliferation, and cell fate decisions in various tissue stem cell compartments, which maintain organs with a high…”
Get full text

The Conundrum of the Pericentral Hepatic Niche: WNT/β-Catenin Signaling, Metabolic Zonation, and Many Open Questions by Tchorz, Jan S

“…WNT/β-catenin signaling promotes stemness, proliferation, and cell fate decisions in various tissue stem cell compartments, which maintain organs with a high…”
Get full text

Clinical translation of liver regeneration therapies: A conceptual road map by Greenbaum, Linda E., Ukomadu, Chinweike, Tchorz, Jan S.

“…[Display omitted] The increasing incidence of severe liver diseases worldwide has resulted in a high demand for curative liver transplantation. Unfortunately,…”
Get full text

mTORC1 signaling suppresses Wnt/β-catenin signaling through DVL-dependent regulation of Wnt receptor FZD level by Zeng, Hao, Lu, Bo, Zamponi, Raffaella, Yang, Zinger, Wetzel, Kristie, Loureiro, Joseph, Mohammadi, Sina, Beibel, Martin, Bergling, Sebastian, Reece-Hoyes, John, Russ, Carsten, Roma, Guglielmo, Tchorz, Jan S., Capodieci, Paola, Cong, Feng

“…Wnt/β-catenin signaling plays pivotal roles in cell proliferation and tissue homeostasis by maintaining somatic stem cell functions. The mammalian target of…”
Get full text

GABA suppresses neurogenesis in the adult hippocampus through GABAB receptors by Giachino, Claudio, Barz, Michael, Tchorz, Jan S, Tome, Mercedes, Gassmann, Martin, Bischofberger, Josef, Bettler, Bernhard, Taylor, Verdon

“…Adult neurogenesis is tightly regulated through the interaction of neural stem/progenitor cells (NSCs) with their niche. Neurotransmitters, including GABA…”
Get full text

Bipotent transitional liver progenitor cells contribute to liver regeneration by Pu, Wenjuan, Zhu, Huan, Zhang, Mingjun, Pikiolek, Monika, Ercan, Caner, Li, Jie, Huang, Xiuzhen, Han, Ximeng, Zhang, Zhenqian, Lv, Zan, Li, Yan, Liu, Kuo, He, Lingjuan, Liu, Xiuxiu, Heim, Markus H., Terracciano, Luigi M., Tchorz, Jan S., Zhou, Bin

“…Following severe liver injury, when hepatocyte-mediated regeneration is impaired, biliary epithelial cells (BECs) can transdifferentiate into functional…”
Get full text

YAP, but Not RSPO-LGR4/5, Signaling in Biliary Epithelial Cells Promotes a Ductular Reaction in Response to Liver Injury by Planas-Paz, Lara, Sun, Tianliang, Pikiolek, Monika, Cochran, Nadire R., Bergling, Sebastian, Orsini, Vanessa, Yang, Zinger, Sigoillot, Frederic, Jetzer, Jasna, Syed, Maryam, Neri, Marilisa, Schuierer, Sven, Morelli, Lapo, Hoppe, Philipp S., Schwarzer, Wibke, Cobos, Carlos M., Alford, John L., Zhang, Le, Cuttat, Rachel, Waldt, Annick, Carballido-Perrig, Nicole, Nigsch, Florian, Kinzel, Bernd, Nicholson, Thomas B., Yang, Yi, Mao, Xiaohong, Terracciano, Luigi M., Russ, Carsten, Reece-Hoyes, John S., Gubser Keller, Caroline, Sailer, Andreas W., Bouwmeester, Tewis, Greenbaum, Linda E., Lugus, Jesse J., Cong, Feng, McAllister, Gregory, Hoffman, Gregory R., Roma, Guglielmo, Tchorz, Jan S.

“…Biliary epithelial cells (BECs) form bile ducts in the liver and are facultative liver stem cells that establish a ductular reaction (DR) to support liver…”
Get full text

Hepatic ductular reaction: a double-edged sword by Sun, Tianliang, Annunziato, Stefano, Tchorz, Jan S

Get full text

ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation by Sun, Tianliang, Annunziato, Stefano, Bergling, Sebastian, Sheng, Caibin, Orsini, Vanessa, Forcella, Pascal, Pikiolek, Monika, Kancherla, Venkatesh, Holwerda, Sjoerd, Imanci, Dilek, Wu, Fabian, Meylan, Ludivine Challet, Puehringer, Lea F., Waldt, Annick, Oertli, Mevion, Schuierer, Sven, Terracciano, Luigi M., Reinker, Stefan, Ruffner, Heinz, Bouwmeester, Tewis, Sailer, Andreas W., George, Elizabeth, Roma, Guglielmo, de Weck, Antoine, Piscuoglio, Salvatore, Lohmann, Felix, Naumann, Ulrike, Liberali, Prisca, Cong, Feng, Tchorz, Jan S.

“…AXIN2 and LGR5 mark intestinal stem cells (ISCs) that require WNT/β-Catenin signaling for constant homeostatic proliferation. In contrast, AXIN2/LGR5+…”
Get full text