Search Results - "Tchkonia, Tamar"

New Horizons: Novel Approaches to Enhance Healthspan Through Targeting Cellular Senescence and Related Aging Mechanisms by Tchkonia, Tamar, Palmer, Allyson K, Kirkland, James L

“…Abstract The elderly population is increasing faster than other segments of the population throughout the world. Age is the leading predictor for most chronic…”
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Discovery, development, and future application of senolytics: theories and predictions by Wissler Gerdes, Erin O., Zhu, Yi, Tchkonia, Tamar, Kirkland, James L.

“…Senescent cells accumulate with aging and at etiological sites of multiple diseases, including those accounting for most morbidity, mortality, and health…”
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Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span by Robbins, Paul D, Jurk, Diana, Khosla, Sundeep, Kirkland, James L, LeBrasseur, Nathan K, Miller, Jordan D, Passos, João F, Pignolo, Robert J, Tchkonia, Tamar, Niedernhofer, Laura J

“…Senescence is the consequence of a signaling mechanism activated in stressed cells to prevent proliferation of cells with damage. Senescent cells (Sncs) often…”
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Impact of Senescent Cell Subtypes on Tissue Dysfunction and Repair: Importance and Research Questions by Tripathi, Utkarsh, Misra, Avanish, Tchkonia, Tamar, Kirkland, James L.

“…•Cellular senescence is a dynamic process and appears to be a heterogenous cell fate.•We hypothesize that senescent cells can be of helper (H) or deleterious…”
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Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study by Justice, Jamie N., Nambiar, Anoop M., Tchkonia, Tamar, LeBrasseur, Nathan K., Pascual, Rodolfo, Hashmi, Shahrukh K., Prata, Larissa, Masternak, Michal M., Kritchevsky, Stephen B., Musi, Nicolas, Kirkland, James L.

“…Cellular senescence is a key mechanism that drives age-related diseases, but has yet to be targeted therapeutically in humans. Idiopathic pulmonary fibrosis…”
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Cellular senescence drives age-dependent hepatic steatosis by Ogrodnik, Mikolaj, Miwa, Satomi, Tchkonia, Tamar, Tiniakos, Dina, Wilson, Caroline L., Lahat, Albert, Day, Christoper P., Burt, Alastair, Palmer, Allyson, Anstee, Quentin M., Grellscheid, Sushma Nagaraja, Hoeijmakers, Jan H J., Barnhoorn, Sander, Mann, Derek A., Bird, Thomas G., Vermeij, Wilbert P., Kirkland, James L., Passos, João F., von Zglinicki, Thomas, Jurk, Diana

“…The incidence of non-alcoholic fatty liver disease (NAFLD) increases with age. Cellular senescence refers to a state of irreversible cell-cycle arrest combined…”
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Senolytics: Potential for Alleviating Diabetes and Its Complications by Palmer, Allyson K, Tchkonia, Tamar, Kirkland, James L

“…Therapeutics that target cellular senescence, including novel “senolytic” compounds, hold significant promise for treating or preventing obesity-induced…”
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Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice by Ogrodnik, Mikolaj, Evans, Shane A., Fielder, Edward, Victorelli, Stella, Kruger, Patrick, Salmonowicz, Hanna, Weigand, Bettina M., Patel, Ayush D., Pirtskhalava, Tamar, Inman, Christine L., Johnson, Kurt O., Dickinson, Stephanie L., Rocha, Azucena, Schafer, Marissa J., Zhu, Yi, Allison, David B., Zglinicki, Thomas, LeBrasseur, Nathan K., Tchkonia, Tamar, Neretti, Nicola, Passos, João F., Kirkland, James L., Jurk, Diana

“…Cellular senescence is characterized by an irreversible cell cycle arrest and a pro‐inflammatory senescence‐associated secretory phenotype (SASP), which is a…”
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Potential Clinical Implications of Senotherapies for Cardiovascular Disease by Suda, Masayoshi, Katsuumi, Goro, Tchkonia, Tamar, Kirkland, James L., Minamino, Tohru

“…Aging is a major risk factor for cardiovascular diseases (CVDs) and accumulating evidence indicates that biological aging has a significant effect on the onset…”
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Pathogenesis of pancreatic cancer exosome-induced lipolysis in adipose tissue by Sagar, Gunisha, Sah, Raghuwansh P, Javeed, Naureen, Dutta, Shamit K, Smyrk, Thomas C, Lau, Julie S, Giorgadze, Nino, Tchkonia, Tamar, Kirkland, James L, Chari, Suresh T, Mukhopadhyay, Debabrata

“…New-onset diabetes and concomitant weight loss occurring several months before the clinical presentation of pancreatic cancer (PC) appear to be paraneoplastic…”
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The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline by Chini, Claudia, Hogan, Kelly A., Warner, Gina M., Tarragó, Mariana G., Peclat, Thais R., Tchkonia, Tamar, Kirkland, James L., Chini, Eduardo

“…Tissue nicotinamide adenine dinucleotide (NAD+) decline has been implicated in aging. We have recently identified CD38 as a central regulator involved in…”
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Targeting senescent cells enhances adipogenesis and metabolic function in old age by Xu, Ming, Palmer, Allyson K, Ding, Husheng, Weivoda, Megan M, Pirtskhalava, Tamar, White, Thomas A, Sepe, Anna, Johnson, Kurt O, Stout, Michael B, Giorgadze, Nino, Jensen, Michael D, LeBrasseur, Nathan K, Tchkonia, Tamar, Kirkland, James L

“…Senescent cells accumulate in fat with aging. We previously found genetic clearance of senescent cells from progeroid INK-ATTAC mice prevents lipodystrophy…”
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Premature Physiologic Aging as a Paradigm for Understanding Increased Risk of Adverse Health Across the Lifespan of Survivors of Childhood Cancer by Ness, Kirsten K, Kirkland, James L, Gramatges, Maria Monica, Wang, Zhaoming, Kundu, Mondira, McCastlain, Kelly, Li-Harms, Xiujie, Zhang, Jinghui, Tchkonia, Tamar, Pluijm, Saskia Martine Francesca, Armstrong, Gregory T

“…The improvement in survival of childhood cancer observed across the past 50 years has resulted in a growing acknowledgment that simply extending the lifespan…”
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Targeting cellular senescence in metabolic disease by Palmer, Allyson K, Tchkonia, Tamar, Kirkland, James L

“…Cellular senescence is a cell fate involving cell cycle arrest, resistance against apoptosis, and the development of a secretome that can be pro-inflammatory…”
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Cell senescence, the senescence-associated secretory phenotype, and cancers by Langhi Prata, Larissa G P, Tchkonia, Tamar, Kirkland, James L

“…Cellular senescence is a cell fate caused by multiple stresses. A 2008 article in PLOS Biology reported a senescence-associated secretory phenotype that can…”
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Chronic HIV Infection and Aging: Application of a Geroscience-Guided Approach by Masters, Mary C., Landay, Alan L., Robbins, Paul D., Tchkonia, Tamar, Kirkland, James L., Kuchel, George A., Niedernhofer, Laura J., Palella, Frank J.

“…The ability of virally suppressive antiretroviral therapy use to extend the life span of people with HIV (PWH) implies that the age of PWH will also increase…”
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Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling by Carpio, Lomeli R, Bradley, Elizabeth W, McGee-Lawrence, Meghan E, Weivoda, Megan M, Poston, Daniel D, Dudakovic, Amel, Xu, Ming, Tchkonia, Tamar, Kirkland, James L, van Wijnen, Andre J, Oursler, Merry Jo, Westendorf, Jennifer J

“…Histone deacetylase (HDAC) inhibitors are efficacious epigenetic-based therapies for some cancers and neurological disorders; however, each of these drugs…”
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Human Obesity Induces Dysfunction and Early Senescence in Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells by Conley, Sabena M, Hickson, LaTonya J, Kellogg, Todd A, McKenzie, Travis, Heimbach, Julie K, Taner, Timucin, Tang, Hui, Jordan, Kyra L, Saadiq, Ishran M, Woollard, John R, Isik, Busra, Afarideh, Mohsen, Tchkonia, Tamar, Kirkland, James L, Lerman, Lilach O

“…Chronic inflammatory conditions like obesity may adversely impact the biological functions underlying the regenerative potential of mesenchymal stromal/stem…”
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Senescent Cells: A Therapeutic Target in Cardiovascular Diseases by Suda, Masayoshi, Paul, Karl H, Minamino, Tohru, Miller, Jordan D, Lerman, Amir, Ellison-Hughes, Georgina M, Tchkonia, Tamar, Kirkland, James L

“…Senescent cell accumulation has been observed in age-associated diseases including cardiovascular diseases. Senescent cells lack proliferative capacity and…”
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Mapping cellular senescence networks in human diabetic foot ulcers by Yu, Grace T., Monie, Dileep D., Khosla, Sundeep, Tchkonia, Tamar, Kirkland, James L., Wyles, Saranya P.

“…Cellular senescence, a cell fate defined by irreversible cell cycle arrest, has been observed to contribute to chronic age-related conditions including…”
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