Comparison of the cardioprotective effects of cardos and losartan in rats with experimental chronic cardiac insufficiency

Cardioprotective effect of cardos was revealed on rat model of experimental cardiac insufficiency induced by injectionof isoproterenol. Cardos improved exercise tolerance, cardiac output, and stroke volume. Cardos administered for 28 days was no less effective than losartan.

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Bibliographic Details
Published in:	Bulletin of experimental biology and medicine Vol. 143; no. 4; pp. 434 - 436
Main Authors:	Tiurenkov, I N, Nazvanova, A N, Tchepurina, N G, Kheyfets, I A, Dugina, J L, Martyushev-Poklad, A V, Sergeeva, S A, Epstein, O I
Format:	Journal Article
Language:	English
Published:	United States Springer Nature B.V 01-04-2007
Subjects:	Angiotensin II Type 1 Receptor Blockers - administration & dosage Angiotensin II Type 1 Receptor Blockers - pharmacology Animals Antibodies - immunology Antibodies - pharmacology Cardiotonic Agents - administration & dosage Cardiotonic Agents - pharmacology Chronic Disease Disease Models, Animal Female Heart Failure - chemically induced Heart Failure - drug therapy Isoproterenol - toxicity Losartan - administration & dosage Losartan - pharmacology Male Peptide Fragments - immunology Rats Rats, Wistar Receptor, Angiotensin, Type 1 - chemistry Receptor, Angiotensin, Type 1 - immunology
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Description
Summary:	Cardioprotective effect of cardos was revealed on rat model of experimental cardiac insufficiency induced by injectionof isoproterenol. Cardos improved exercise tolerance, cardiac output, and stroke volume. Cardos administered for 28 days was no less effective than losartan.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-007-0149-0