Search Results - "Taylor, Scott D"
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1
Strain‐dependent differences in coordination of yeast signalling networks
Published in The FEBS journal (01-04-2023)“…The yeast mitogen‐activated protein kinase pathways serve as a model system for understanding how network interactions affect the way in which cells coordinate…”
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2
Cardiolipin Prevents Membrane Translocation and Permeabilization by Daptomycin
Published in The Journal of biological chemistry (25-04-2014)“…Daptomycin is an acidic lipopeptide antibiotic that, in the presence of calcium, forms oligomeric pores on membranes containing phosphatidylglycerol. It is…”
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3
Solid-Phase Total Synthesis of Daptomycin and Analogs
Published in Organic letters (06-02-2015)“…An entirely solid-phase synthesis of daptomycin, a cyclic lipodepsipeptide antibiotic currently in clinical use, was achieved using a combination of α-azido…”
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4
Membrane Binding and Oligomerization of the Lipopeptide A54145 Studied by Pyrene Fluorescence
Published in Biophysical journal (20-09-2016)“…A54145 is a lipopeptide antibiotic related to daptomycin that permeabilizes bacterial cell membranes. Its action requires both calcium and phosphatidylglycerol…”
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5
Synthesis of Nucleoside Tetraphosphates and Dinucleoside Pentaphosphates via Activation of Cyclic Trimetaphosphate
Published in Organic letters (07-06-2013)“…A procedure for the synthesis of dinucleoside 5′-pentaphosphates (Np5N) and nucleoside 5′-tetraphosphates (Np4) is described. The procedure relies on the…”
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6
Total Synthesis of Analogs of A54145D and A54145A1 for Structure–Activity Relationship Studies
Published in Journal of organic chemistry (21-02-2020)“…The total solid-phase synthesis and in vitro biological activity of a series of analogs of A54145 factor D (A5D) and A54145 factor A1 (A5A1), two cyclic…”
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7
Tensor‐structured decomposition improves systems serology analysis
Published in Molecular systems biology (01-09-2021)“…Systems serology provides a broad view of humoral immunity by profiling both the antigen‐binding and Fc properties of antibodies. These studies contain…”
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8
Natural hybridization between divergent lineages in a selfing hermaphroditic fish
Published in Biology letters (2005) (01-06-2018)“…By definition, mating between individuals is infrequent in highly selfing organisms, and so too, therefore, hybridization should be rare between genetically…”
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9
General Procedure for the Synthesis of Dinucleoside Polyphosphates
Published in Journal of organic chemistry (05-08-2011)“…Dinucleoside 5′,5′-polyphosphates (N(p) n N) play important roles in biological processes and have been developed into drugs. However, their synthesis still…”
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10
Genetic Subdivision and Variation in Selfing Rates Among Central American Populations of the Mangrove Rivulus, Kryptolebias marmoratus
Published in The Journal of heredity (01-05-2015)“…We used 32 polymorphic microsatellite loci to investigate how a mixed-mating system affects population genetic structure in Central American populations (N =…”
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11
Out to sea: ocean currents and patterns of asymmetric gene flow in an intertidal fish species
Published in Frontiers in genetics (28-06-2023)“…Passive dispersal via wind or ocean currents can drive asymmetric gene flow, which influences patterns of genetic variation and the capacity of populations to…”
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12
The action mechanism of daptomycin
Published in Bioorganic & medicinal chemistry (15-12-2016)“…[Display omitted] Daptomycin is a lipopeptide antibiotic produced by the soil bacterium Streptomyces roseosporus that is clinically used to treat severe…”
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13
Correction: Measurement and models accounting for cell death capture hidden variation in compound response
Published in Cell death & disease (24-08-2020)“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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14
Long-term retention of self-fertilization in a fish clade
Published in Proceedings of the National Academy of Sciences - PNAS (25-08-2009)“…Among vertebrate animals, only the mangrove rivulus (Kryptolebias marmoratus) was known to self-fertilize. Here, we use microsatellite analyses to document a…”
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15
Extensive Outcrossing and Androdioecy in a Vertebrate Species That Otherwise Reproduces as a Self-Fertilizing Hermaphrodite
Published in Proceedings of the National Academy of Sciences - PNAS (27-06-2006)“…The mangrove killifish (Kryptolebias marmoratus) is the only vertebrate known to be capable of self-fertilization. Its gonad is typically an ovotestis that…”
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16
Efficient Solid-Phase Synthesis of Sulfotyrosine Peptides using a Sulfate Protecting-Group Strategy
Published in Angewandte Chemie (International ed.) (01-01-2009)“…Double protection: Efficient Fmoc-based solid-phase synthesis (SPPS) of sulfotyrosine (sY) peptides is achieved by incorporating the sY residue(s) as a…”
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17
Synthesis, mechanism of action, and SAR studies on the cyclic lipopeptide antibiotic daptomycin
Published in Canadian journal of chemistry (01-07-2024)“…Daptomycin is a calcium-dependent cyclic lipopeptide antibiotic. It is one of only two new structural classes of antibiotics that have been approved for…”
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The Chiral Target of Daptomycin Is the 2R,2′S Stereoisomer of Phosphatidylglycerol
Published in Angewandte Chemie International Edition (21-01-2022)“…Daptomycin (dap) is an important antibiotic that interacts with the bacterial membrane lipid phosphatidylglycerol (PG) in a calcium‐dependent manner. The…”
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19
O- and N-Sulfations of Carbohydrates Using Sulfuryl Imidazolium Salts
Published in Journal of organic chemistry (04-09-2009)“…A series of sulfuryl imidazolium salts (SISs) were prepared and examined as reagents for incorporating trichloroethyl-protected sulfate esters into…”
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20
Thermoresponsive Starch for the Flocculation of Oil Sands Mature Fine Tailings
Published in Environmental science & technology (03-11-2020)“…The reclamation of land and recovery of water from tailing ponds created during bitumen extraction from oil sands is a major technical and environmental…”
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