Search Results - "Taylor, Philip R."

Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells by Ma, Yuting, Adjemian, Sandy, Mattarollo, Stephen R., Yamazaki, Takahiro, Aymeric, Laetitia, Yang, Heng, Portela Catani, João Paulo, Hannani, Dalil, Duret, Helene, Steegh, Kim, Martins, Isabelle, Schlemmer, Frederic, Michaud, Mickaël, Kepp, Oliver, Sukkurwala, Abdul Qader, Menger, Laurie, Vacchelli, Erika, Droin, Nathalie, Galluzzi, Lorenzo, Krzysiek, Roman, Gordon, Siamon, Taylor, Philip R., Van Endert, Peter, Solary, Eric, Smyth, Mark J., Zitvogel, Laurence, Kroemer, Guido

“…The therapeutic efficacy of anthracyclines relies on antitumor immune responses elicited by dying cancer cells. How chemotherapy-induced cell death leads to…”
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The Transcription Factor Gata6 Links Tissue Macrophage Phenotype and Proliferative Renewal by Rosas, Marcela, Davies, Luke C., Giles, Peter J., Liao, Chia-Te, Kharfan, Bashar, Stone, Timothy C., O'Donnell, Valerie B., Fraser, Donald J., Jones, Simon A., Taylor, Philip R.

“…Tissue-resident macrophages are heterogeneous as a consequence of anatomical niche–specific functions. Many populations self-renew independently of bone marrow…”
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Macrophage reprogramming for therapy by Bart, Valentina M. T., Pickering, Robert J., Taylor, Philip R., Ipseiz, Natacha

“…Summary Dysfunction of the immune system underlies a plethora of human diseases, requiring the development of immunomodulatory therapeutic intervention. To…”
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Understanding Local Macrophage Phenotypes In Disease: Shape-shifting macrophages by Liddiard, Kate, Taylor, Philip R

“…Macrophages are responsive to local tissue signals and alter their phenotypes accordingly. In disease tissues this means that macrophage phenotypes may change…”
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Peritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels by Davies, Luke C., Rice, Christopher M., Palmieri, Erika M., Taylor, Philip R., Kuhns, Douglas B., McVicar, Daniel W.

“…The importance of metabolism in macrophage function has been reported, but the in vivo relevance of the in vitro observations is still unclear. Here we show…”
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Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation by Davies, Luke C., Rosas, Marcela, Jenkins, Stephen J., Liao, Chia-Te, Scurr, Martin J., Brombacher, Frank, Fraser, Donald J., Allen, Judith E., Jones, Simon A., Taylor, Philip R.

“…The general paradigm is that monocytes are recruited to sites of inflammation and terminally differentiate into macrophages. There has been no demonstration of…”
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Squamous dysplasia--the precursor lesion for esophageal squamous cell carcinoma by Taylor, Philip R, Abnet, Christian C, Dawsey, Sanford M

“…Esophageal squamous cell carcinoma (ESCC) accounts for 80% of all esophageal cancers worldwide, and esophageal squamous dysplasia (ESD) is the only…”
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Integrated analysis of genome-wide miRNAs and targeted gene expression in esophageal squamous cell carcinoma (ESCC) and relation to prognosis by Yang, Howard, Su, Hua, Hu, Nan, Wang, Chaoyu, Wang, Lemin, Giffen, Carol, Goldstein, Alisa M, Lee, Maxwell P, Taylor, Philip R

“…Esophageal squamous cell carcinoma (ESCC) is a leading cause of cancer death worldwide and in China. We know miRNAs influence gene expression in tumorigenesis,…”
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Modest changes in Spi1 dosage reveal the potential for altered microglial function as seen in Alzheimer’s disease by Jones, Ruth E., Andrews, Robert, Holmans, Peter, Hill, Matthew, Taylor, Philip R.

“…Genetic association studies have identified multiple variants at the SPI1 locus that modify risk and age of onset for Alzheimer’s Disease (AD). Reports linking…”
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The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors by Thompson, Aiysha, Davies, Luke C, Liao, Chia-Te, da Fonseca, Diogo M, Griffiths, James S, Andrews, Robert, Jones, Adam V, Clement, Mathew, Brown, Gordon D, Humphreys, Ian R, Taylor, Philip R, Orr, Selinda J

“…Invasive candidiasis, mainly caused by Candida albicans, is a serious healthcare problem with high mortality rates, particularly in immunocompromised patients…”
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A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation by Davies, Luke C., Rosas, Marcela, Smith, Paul J., Fraser, Donald J., Jones, Simon A., Taylor, Philip R.

“…Macrophage (MØ) biology is routinely modelled in the peritoneal cavity, a vascular tissue readily infiltrated by leukocytes during inflammation. After several…”
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Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation by Misheva, Mariya, Kotzamanis, Konstantinos, Davies, Luke C., Tyrrell, Victoria J., Rodrigues, Patricia R. S., Benavides, Gloria A., Hinz, Christine, Murphy, Robert C., Kennedy, Paul, Taylor, Philip R., Rosas, Marcela, Jones, Simon A., McLaren, James E., Deshpande, Sumukh, Andrews, Robert, Schebb, Nils Helge, Czubala, Magdalena A., Gurney, Mark, Aldrovandi, Maceler, Meckelmann, Sven W., Ghazal, Peter, Darley-Usmar, Victor, White, Daniel A., O’Donnell, Valerie B.

“…Oxylipins are potent biological mediators requiring strict control, but how they are removed en masse during infection and inflammation is unknown. Here we…”
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Associations between serum glucose, insulin, insulin resistance and the risk of incident primary liver cancer or chronic liver disease mortality: a nested case–control study by Yin, Jian, Freedman, Neal D., Liu, Yiwei, Dawsey, Sanford M., Yang, Huan, Taylor, Philip R., Yin, Liangyu, Liu, Bin, Cui, Jianfeng, Fan, Jinhu, Chen, Wen, Qiao, Youlin, Abnet, Christian C.

“…Background To evaluate the associations between pre-diagnostic levels of serum insulin, glucose and insulin resistance (HOMA-IR) and future risk of incident…”
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Molecular Characterization of the Human Stomach Microbiota in Gastric Cancer Patients by Yu, Guoqin, Torres, Javier, Hu, Nan, Medrano-Guzman, Rafael, Herrera-Goepfert, Roberto, Humphrys, Michael S, Wang, Lemin, Wang, Chaoyu, Ding, Ti, Ravel, Jacques, Taylor, Philip R, Abnet, Christian C, Goldstein, Alisa M

“…( ) is the primary cause of gastric cancer but we know little of its relative abundance and other microbes in the stomach, especially at the time of gastric…”
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Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection by Robinson, Matthew J, Osorio, Fabiola, Rosas, Marcela, Freitas, Rui P, Schweighoffer, Edina, Gross, Olaf, Verbeek, J Sjef, Ruland, Jürgen, Tybulewicz, Victor, Brown, Gordon D, Moita, Luis Ferreira, Taylor, Philip R, Reis e Sousa, Caetano

“…Innate immune cells detect pathogens via pattern recognition receptors (PRRs), which signal for initiation of immune responses to infection. Studies with…”
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Sex-specific proximal tubular cell differentiation pathways identified by single-nucleus RNA sequencing by Lu, Yueh-An, Smith, Tanya, Deshpande, Sumukh, Liao, Chia-Te, Talabani, Bnar, Grigorieva, Irina, Mason, Anna, Andrews, Robert, Bowen, Timothy, Taylor, Philip R., Fraser, Donald

“…Postnatal kidney growth is substantial and involves expansion in kidney tubules without growth of new nephrons, which are the functional units of the kidney…”
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Index‐based dietary patterns and risk of incident hepatocellular carcinoma and mortality from chronic liver disease in a prospective study by Li, Wen‐Qing, Park, Yikyung, McGlynn, Katherine A., Hollenbeck, Albert R., Taylor, Philip R., Goldstein, Alisa M., Freedman, Neal D.

“…The role of diet in hepatocellular carcinoma (HCC) and its typical precursor, chronic liver disease (CLD), is poorly understood. Following dietary…”
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A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma by Wang, Zhaoming, Yuan, Jian-Min, Giffen, Carol A, Zheng, Wei, Wang, Chaoyu, Taylor, Philip R, Koh, Woon-Puay, Wheeler, William, Abnet, Christian C, Xiang, Yong-Bing, Gail, Mitchell H, Fan, Jin-Hu, Yuenger, Jeff, Lee, Maxwell P, Ding, Ti, Fraumeni, Joseph F, Dong, Linda M, Hutchinson, Amy, Tucker, Margaret A, Chanock, Stephen J, Freedman, Neal D, Shu, Xiao-Ou, Dawsey, Sanford M, Goldstein, Alisa M, Gao, Yu-Tang, Hu, Nan, Yu, Kai, Burdett, Laurie, Qiao, You-Lin, Jacobs, Kevin B, Chow, Wong-Ho, Tang, Ze-Zhong, Yeager, Meredith

“…We conducted a genome-wide association study of gastric cancer and esophageal squamous cell carcinoma (ESCC) in ethnic Chinese subjects in which we genotyped…”
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track2KBA: An R package for identifying important sites for biodiversity from tracking data by Beal, Martin, Oppel, Steffen, Handley, Jonathan, Pearmain, Elizabeth J., Morera‐Pujol, Virginia, Carneiro, Ana P. B., Davies, Tammy E., Phillips, Richard A., Taylor, Philip R., Miller, Mark G. R., Franco, Aldina M. A., Catry, Inês, Patrício, Ana R., Regalla, Aissa, Staniland, Iain, Boyd, Charlotte, Catry, Paulo, Dias, Maria P.

“…Identifying important sites for biodiversity is vital for conservation and management. However, there is a lack of accessible, easily applied tools that enable…”
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Association between circulating levels of sex steroid hormones and esophageal adenocarcinoma in the FINBAR Study by Petrick, Jessica L, Falk, Roni T, Hyland, Paula L, Caron, Patrick, Pfeiffer, Ruth M, Wood, Shannon N, Dawsey, Sanford M, Abnet, Christian C, Taylor, Philip R, Guillemette, Chantal, Murray, Liam J, Anderson, Lesley A, Cook, Michael B

“…Esophageal adenocarcinoma (EA) is characterized by a strong male predominance. Sex steroid hormones have been hypothesized to underlie this sex disparity, but…”
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