Search Results - "Taylor, Patricia M."

Molecular and functional characteristics of heart-valve interstitial cells by Chester, Adrian H, Taylor, Patricia M

“…The cells that reside within valve cusps play an integral role in the durability and function of heart valves. There are principally two types of cells found…”
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Biological matrices and bionanotechnology by Taylor, Patricia M

“…A crucial step towards the goal of tissue engineering a heart valve will be the choice of scaffold onto which an appropriate cell phenotype can be seeded…”
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Extracellular matrix production by adipose-derived stem cells: Implications for heart valve tissue engineering by Colazzo, Francesca, Sarathchandra, Padmini, Smolenski, Ryszard T, Chester, Adrian H, Tseng, Yuan-Tsan, Czernuszka, Jan T, Yacoub, Magdi H, Taylor, Patricia M

“…Abstract A key challenge in tissue engineering a heart valve is to reproduce the major tissue structures responsible for native valve function. Here we…”
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Endothelium-Dependent Regulation of the Mechanical Properties of Aortic Valve Cusps by El-Hamamsy, Ismail, MD, Balachandran, Kartik, MS, Yacoub, Magdi H., FRS, Stevens, Louis M., MD, SM, Sarathchandra, Padmini, PhD, Taylor, Patricia M., PhD, Yoganathan, Ajit P., PhD, Chester, Adrian H., PhD

“…Objectives The aim of this study was to evaluate the role of valve endothelium in regulating the mechanical properties of aortic valve cusps. Background…”
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Shear stress and VEGF enhance endothelial differentiation of human adipose-derived stem cells by Colazzo, Francesca, Alrashed, Fahad, Saratchandra, Padmini, Carubelli, Ivan, Chester, Adrian H., Yacoub, Magdi H., Taylor, Patricia M., Somers, Pamela

“…Abstract Herein we combine chemical and mechanical stimulation to investigate the effects of vascular endothelial growth factor (VEGF) and physiological shear…”
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Transforming growth factor beta 1 and hyaluronan oligomers synergistically enhance elastin matrix regeneration by vascular smooth muscle cells by Kothapalli, Chandrasekhar R, Taylor, Patricia M, Smolenski, Ryszard T, Yacoub, Magdi H, Ramamurthi, Anand

“…Elastin is a vital structural and regulatory matrix protein that plays an important role in conferring elasticity to blood vessel wall. Previous tissue…”
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Impact of γ-Irradiation on Extracellular Matrix of Porcine Pulmonary Valves by Sarathchandra, Padmini, Ph.D, Smolenski, Ryszard T., Ph.D, Yuen, Ada H.Y., B.Sc, Chester, Adrian H., Ph.D, Goldstein, Steven, Ph.D, Heacox, Albert E., Ph.D, Yacoub, Magdi H., F.R.S, Taylor, Patricia M., Ph.D

“…Background The extracellular matrix plays an important role in heart valve function. To improve the processing of porcine pulmonary valves for clinical use, we…”
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Collagen synthesis by mesenchymal stem cells and aortic valve interstitial cells in response to mechanical stretch by KU, Ching-Hsin, JOHNSON, Philip H, BATTEN, Puspa, SARATHCHANDRA, Padmini, CHAMBERS, Rachel C, TAYLOR, Patricia M, YACOUB, Magdi H, CHESTER, Adrian H

“…The synthesis of appropriate extracellular matrix by cells in tissue engineered heart valve constructs will be important for the maintenance of valve cusp…”
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The cardiac valve interstitial cell by Taylor, Patricia M, Batten, Puspa, Brand, Nigel J, Thomas, Penny S, Yacoub, Magdi H

“…Cardiac valve interstitial cells (ICs) are a heterogeneous and dynamic population of specific cell types that have many unique characteristics. They are…”
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Induction of mesenchymal to endothelial transformation of adipose-derived stem cells by Colazzo, Francesca, Chester, Adrian H, Taylor, Patricia M, Yacoub, Magdi H

“…Adipose tissue is a readily available source of multipotent adult stem cells for use in tissue engineering and regenerative medicine. Adipose-derived stem…”
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Time-dependent mechanical properties of aortic valve cusps: Effect of glycosaminoglycan depletion by Borghi, Alessandro, New, Sophie E.P., Chester, Adrian H., Taylor, Patricia M., Yacoub, Magdi H.

“…Aortic valve (AV) performance is closely linked to its structural components. Glycosaminoglycans (GAGs) are thought to influence the time-dependent properties…”
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A novel role of the sympatho-adrenergic system in regulating valve calcification by OSMAN, Lana, CHESTER, Adrian H, SARATHCHANDRA, Padmini, LATIF, Najma, WENFANG MENG, TAYLOR, Patricia M, YACOUB, Magdi H

“…Aortic valve calcification is a progressive process resembling ossification. Recent evidence indicates that the sympathetic nervous system plays an important…”
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Localization and pattern of expression of extracellular matrix components in human heart valves by Latif, Najma, Sarathchandra, Padmini, Taylor, Patricia M, Antoniw, Joseph, Yacoub, Magdi H

“…The pattern of expression and distribution of extracellular matrix (ECM) components in human cardiac leaflets was analyzed. Additionally, interstitial cells…”
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Interaction of human valve interstitial cells with collagen matrices manufactured using rapid prototyping by Taylor, Patricia M., Sachlos, Eleftherios, Dreger, Sally A., Chester, Adrian H., Czernuszka, Jan T., Yacoub, Magdi H.

“…Rapid prototyping is a novel process for the production of scaffolds of predetermined size and three-dimensional shape. The aim of the study was to determine…”
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Human mesenchymal stem cells induce T cell anergy and downregulate T cell allo-responses via the TH2 pathway: relevance to tissue engineering human heart valves by Batten, Puspa, Sarathchandra, Padmini, Antoniw, Joseph W, Tay, Szun Szun, Lowdell, Mark W, Taylor, Patricia M, Yacoub, Magdi H

“…To generate an ''off the shelf'' tissue-engineered heart valve, the cells would need to be of allogeneic origin. Here, we report the possibility of using human…”
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Nucleotide Catabolism on the Surface of Aortic Valve Xenografts; Effects of Different Decellularization Strategies by Kutryb-Zajac, Barbara, Yuen, Ada H. Y., Khalpey, Zain, Zukowska, Paulina, Slominska, Ewa M., Taylor, Patricia M., Goldstein, Steven, Heacox, Albert E., Lavitrano, Marialuisa, Chester, Adrian H., Yacoub, Magdi H., Smolenski, Ryszard T.

“…Extracellular nucleotide metabolism controls thrombosis and inflammation and may affect degeneration and calcification of aortic valve prostheses. We evaluated…”
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Characterization of structural and signaling molecules by human valve interstitial cells and comparison to human mesenchymal stem cells by Latif, Najma, Sarathchandra, Padmini, Thomas, Penny S, Antoniw, Joe, Batten, Puspa, Chester, Adrian H, Taylor, Patricia M, Yacoub, Magdi H

“…Human mesenchymal stem cells (MSCs) are a potential cell source for the tissue engineering of biological structures, including cardiac valves. A comprehensive,…”
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Human cardiac valve interstitial cells in collagen sponge: a biological three-dimensional matrix for tissue engineering by Taylor, Patricia M, Allen, Sean P, Dreger, Sally A, Yacoub, Magdi H

“…The use of a biological, biodegradable scaffold remodeled by cells to resemble a valve leaflet is an attractive approach to tissue engineering. The study aim…”
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Profile and localization of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in human heart valves by Dreger, Sally A, Taylor, Patricia M, Allen, Sean P, Yacoub, Magdi H

“…Tissue turnover is one of many factors involved in the operational longevity of heart valves. An understanding of how valves remodel their matrix in response…”
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Magnetic resonance imaging of ferumoxide-labeled mesenchymal stem cells seeded on collagen scaffolds-relevance to tissue engineering by Terrovitis, John V, Bulte, Jeff W M, Sarvananthan, Sajiram, Crowe, Lindsey A, Sarathchandra, Padmini, Batten, Puspa, Sachlos, Eleftherios, Chester, Adrian H, Czernuszka, Jan T, Firmin, David N, Taylor, Patricia M, Yacoub, Magdi H

“…Mesenchymal stem cells (MSCs) are a promising candidate cell for tissue engineering. Magnetic resonance imaging (MRI) has been proven effective in visualizing…”
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