Search Results - "Taylor, Neil A."

Thiol isomerases negatively regulate the cellular shedding activity of ADAM17 by Willems, Sofie H, Tape, Christopher J, Stanley, Peter L, Taylor, Neil A, Mills, Ian G, Neal, David E, McCafferty, John, Murphy, Gillian

“…ADAM17 (where ADAM is 'a disintegrin and metalloproteinase') can rapidly modulate cell-surface signalling events by the proteolytic release of soluble forms of…”
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Curbing activation: proprotein convertases in homeostasis and pathology by Taylor, Neil A., Van De Ven, Wim J. M., Creemers, John W. M.

“…ABSTRACT The proprotein convertases (PCs) are a seven‐member family of endoproteases that activate proproteins by cleavage at basic motifs. Expression patterns…”
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Role of furin in granular acidification in the endocrine pancreas: Identification of the V-ATPase subunit Ac45 as a candidate substrate by Louagie, Els, Taylor, Neil A, Flamez, Daisy, Roebroek, Anton J.M, Bright, Nicholas A, Meulemans, Sandra, Quintens, Roel, Herrera, Pedro L, Schuit, Frans, Van de Ven, Wim J.M, Creemers, John W.M

“…Furin is a proprotein convertase which activates a variety of regulatory proteins in the constitutive exocytic and endocytic pathway. The effect of genetic…”
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Limited Redundancy of the Proprotein Convertase Furin in Mouse Liver by Roebroek, Anton J.M., Taylor, Neil A., Louagie, Els, Pauli, Ilse, Smeijers, Liesbeth, Snellinx, An, Lauwers, Annick, Van de Ven, Wim J.M., Hartmann, Dieter, Creemers, John W.M.

“…Furin is an endoprotease of the family of mammalian proprotein convertases and is involved in the activation of a large variety of regulatory proteins by…”
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Differences in pH Optima and Calcium Requirements for Maturation of the Prohormone Convertases PC2 and PC3 Indicates Different Intracellular Locations for These Events (∗) by Shennan, Kathleen I.J., Taylor, Neil A., Jermany, Joanne L., Matthews, Glenn, Docherty, Kevin

“…PC2 and PC3, which is also known as PC1, are subtilisin-like proteases that are involved in the intracellular processing of prohormones and proneuropeptides…”
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Processing of β-Secretase by Furin and Other Members of the Proprotein Convertase Family by Creemers, John W.M., Ines Dominguez, Diana, Plets, Evelyn, Serneels, Lutgarde, Taylor, Neil A., Multhaup, Gerd, Craessaerts, Katleen, Annaert, Wim, De Strooper, Bart

“…The amyloid peptide is the main constituent of the amyloid plaques in brain of Alzheimer's disease patients. This peptide is generated from the amyloid…”
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Processing of β-Secretase by Furin and Other Members of the Proprotein Convertase Family by John W. M. Creemers, Diana Ines Dominguez, Evelyn Plets, Lutgarde Serneels, Neil A. Taylor, Gerd Multhaup, Katleen Craessaerts, Wim Annaert, Bart De Strooper

“…The amyloid peptide is the main constituent of the amyloid plaques in brain of Alzheimer's disease patients. This peptide is generated from the amyloid…”
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Autocatalytic maturation of the prohormone convertase PC2 by MATTHEWS, G, SHENNAN, K. I. J, SEAL, A. J, TAYLOR, N. A, COLMAN, A, DOCHERTY, K

“…PC2 is a member of the eukaryotic family of subtilisin-like proteases, which is thought to participate in the processing of prohormones and proneuropeptides in…”
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Mutations within the propeptide, the primary cleavage site or the catalytic site, or deletion of C-terminal sequences, prevents secretion of proPC2 from transfected COS-7 cells by Taylor, N A, Shennan, K I, Cutler, D F, Docherty, K

“…PC2 is a neuroendocrine endoprotease involved in the processing of prohormones and proneuropeptides. PC2 is synthesized as a proenzyme which undergoes…”
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Calcium- and pH-dependent aggregation and membrane association of the precursor of the prohormone convertase PC2 by SHENNAN, K. I. J, TAYLOR, N. A, DOCHERTY, K

“…PC2 is a subtilisin-like protease which is thought to be involved in the processing of prohormones and proneuropeptides in neuroendocrine cells. The mature…”
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Differences in the autocatalytic cleavage of pro-PC2 and pro-PC3 can be attributed to sequences within the propeptide and Asp310 of pro-PC2 by Scougall, K, Taylor, N A, Jermany, J L, Docherty, K, Shennan, K I

“…PC2 and PC3 are subtilisin-like proteases involved in the maturation of prohormones and proneuropeptides within neuroendocrine cells. They are synthesized as…”
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The propeptide of prohormone convertase PC2 acts as a transferable aggregation and membrane‐association signal by Jan, Gwénaël, Taylor, Neil A., Scougall, Kathleen T., Docherty, Kevin, Shennan, Kathleen I. J.

“…Prohormone convertase 2 (PC2) is a subtilisin‐like protease involved in the intracellular processing of prohormones and proneuropeptides. Like its substrates,…”
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Inducible expression of mutant human proinsulins in a mouse pituitary cell line controlled by the mouse metallothionein promotor by Taylor, N A, Shennan, K I, Docherty, K

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