Search Results - "Taylor, Michael D."

Medulloblastoma in the age of molecular subgroups: a review by Juraschka, Kyle, Taylor, Michael D

“…Medulloblastoma is the most common pediatric malignant brain tumor. Advances in molecular profiling have uncovered significant heterogeneity among…”
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Medulloblastoma: From Myth to Molecular by Ramaswamy, Vijay, Taylor, Michael D

“…Current therapies for medulloblastoma were introduced primarily in the 1980s and consist of predominantly cytotoxic, nontargeted approaches. Mortality from…”
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The U1 spliceosomal RNA is recurrently mutated in multiple cancers by Shuai, Shimin, Suzuki, Hiromichi, Diaz-Navarro, Ander, Nadeu, Ferran, Kumar, Sachin A., Gutierrez-Fernandez, Ana, Delgado, Julio, Pinyol, Magda, López-Otín, Carlos, Puente, Xose S., Taylor, Michael D., Campo, Elías, Stein, Lincoln D.

“…Cancers are caused by genomic alterations known as drivers. Hundreds of drivers in coding genes are known but, to date, only a handful of noncoding drivers…”
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Medulloblastoma Comprises Four Distinct Molecular Variants by NORTHCOTT, Paul A, KORSHUNOV, Andrey, RUTKA, James T, PFISTER, Stefan, TAYLOR, Michael D, WITT, Hendrik, HIELSCHER, Thomas, EBERHART, Charles G, MACK, Stephen, BOUFFET, Eric, CLIFFORD, Steven C, HAWKINS, Cynthia E, FRENCH, Pim

“…Recent genomic approaches have suggested the existence of multiple distinct subtypes of medulloblastoma. We studied a large cohort of medulloblastomas to…”
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Risk stratification of childhood medulloblastoma in the molecular era: the current consensus by Ramaswamy, Vijay, Remke, Marc, Bouffet, Eric, Bailey, Simon, Clifford, Steven C., Doz, Francois, Kool, Marcel, Dufour, Christelle, Vassal, Gilles, Milde, Till, Witt, Olaf, von Hoff, Katja, Pietsch, Torsten, Northcott, Paul A., Gajjar, Amar, Robinson, Giles W., Padovani, Laetitia, André, Nicolas, Massimino, Maura, Pizer, Barry, Packer, Roger, Rutkowski, Stefan, Pfister, Stefan M., Taylor, Michael D., Pomeroy, Scott L.

“…Historical risk stratification criteria for medulloblastoma rely primarily on clinicopathological variables pertaining to age, presence of metastases, extent…”
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Second-generation molecular subgrouping of medulloblastoma: an international meta-analysis of Group 3 and Group 4 subtypes by Sharma, Tanvi, Schwalbe, Edward C., Williamson, Daniel, Sill, Martin, Hovestadt, Volker, Mynarek, Martin, Rutkowski, Stefan, Robinson, Giles W., Gajjar, Amar, Cavalli, Florence, Ramaswamy, Vijay, Taylor, Michael D., Lindsey, Janet C., Hill, Rebecca M., Jäger, Natalie, Korshunov, Andrey, Hicks, Debbie, Bailey, Simon, Kool, Marcel, Chavez, Lukas, Northcott, Paul A., Pfister, Stefan M., Clifford, Steven C.

“…In 2012, an international consensus paper reported that medulloblastoma comprises four molecular subgroups (WNT, SHH, Group 3, and Group 4), each associated…”
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DeepVelo: deep learning extends RNA velocity to multi-lineage systems with cell-specific kinetics by Cui, Haotian, Maan, Hassaan, Vladoiu, Maria C, Zhang, Jiao, Taylor, Michael D, Wang, Bo

“…Existing RNA velocity estimation methods strongly rely on predefined dynamics and cell-agnostic constant transcriptional kinetic rates, assumptions often…”
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Association between diffuse myocardial fibrosis and diastolic dysfunction in sickle cell anemia by Niss, Omar, Fleck, Robert, Makue, Fowe, Alsaied, Tarek, Desai, Payal, Towbin, Jeffrey A., Malik, Punam, Taylor, Michael D., Quinn, Charles T.

“…Sickle cell anemia (SCA)–related cardiomyopathy is characterized by diastolic dysfunction and hyperdynamic features. Diastolic dysfunction portends early…”
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Accelerated Cine Cardiac MRI Using Deep Learning‐Based Reconstruction: A Systematic Evaluation by Pednekar, Amol, Kocaoglu, Murat, Wang, Hui, Tanimoto, Aki, Tkach, Jean A., Lang, Sean, Taylor, Michael D.

“…Background Breath‐holding (BH) for cine balanced steady state free precession (bSSFP) imaging is challenging for patients with impaired BH capacity. Deep…”
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HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC-Driven Medulloblastoma by Pei, Yanxin, Liu, Kun-Wei, Wang, Jun, Garancher, Alexandra, Tao, Ran, Esparza, Lourdes A., Maier, Donna L., Udaka, Yoko T., Murad, Najiba, Morrissy, Sorana, Seker-Cin, Huriye, Brabetz, Sebastian, Qi, Lin, Kogiso, Mari, Schubert, Simone, Olson, James M., Cho, Yoon-Jae, Li, Xiao-Nan, Crawford, John R., Levy, Michael L., Kool, Marcel, Pfister, Stefan M., Taylor, Michael D., Wechsler-Reya, Robert J.

“…Medulloblastoma (MB) is a highly malignant pediatric brain tumor. Despite aggressive therapy, many patients succumb to the disease, and survivors experience…”
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Distinct Neural Stem Cell Populations Give Rise to Disparate Brain Tumors in Response to N-MYC by Swartling, Fredrik J., Savov, Vasil, Persson, Anders I., Chen, Justin, Hackett, Christopher S., Northcott, Paul A., Grimmer, Matthew R., Lau, Jasmine, Chesler, Louis, Perry, Arie, Phillips, Joanna J., Taylor, Michael D., Weiss, William A.

“…The proto-oncogene MYCN is mis-expressed in various types of human brain tumors. To clarify how developmental and regional differences influence…”
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The molecular biology of medulloblastoma metastasis by Van Ommeren, Randy, Garzia, Livia, Holgado, Borja L., Ramaswamy, Vijay, Taylor, Michael D.

“…Medulloblastoma (MB) is the most common primary malignant brain tumor of childhood and a significant contributor to pediatric morbidity and death. While…”
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Breath-hold and free-breathing quantitative assessment of biventricular volume and function using compressed SENSE: a clinical validation in children and young adults by Kocaoglu, Murat, Pednekar, Amol S, Wang, Hui, Alsaied, Tarek, Taylor, Michael D, Rattan, Mantosh S

“…Although the breath-hold cine balanced steady state free precession (bSSFP) imaging is well established for assessment of biventricular volumes and function,…”
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YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation by Fernandez-L, Africa, Northcott, Paul A, Dalton, James, Fraga, Charles, Ellison, David, Angers, Stephane, Taylor, Michael D, Kenney, Anna Marie

“…Medulloblastoma is the most common solid malignancy of childhood, with treatment side effects reducing survivors' quality of life and lethality being…”
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The eEF2 Kinase Confers Resistance to Nutrient Deprivation by Blocking Translation Elongation by Leprivier, Gabriel, Remke, Marc, Rotblat, Barak, Dubuc, Adrian, Mateo, Abigail-Rachele F., Kool, Marcel, Agnihotri, Sameer, El-Naggar, Amal, Yu, Bin, Prakash Somasekharan, Syam, Faubert, Brandon, Bridon, Gaëlle, Tognon, Cristina E., Mathers, Joan, Thomas, Ryan, Li, Amy, Barokas, Adi, Kwok, Brian, Bowden, Mary, Smith, Stephanie, Wu, Xiaochong, Korshunov, Andrey, Hielscher, Thomas, Northcott, Paul A., Galpin, Jason D., Ahern, Christopher A., Wang, Ye, McCabe, Martin G., Collins, V. Peter, Jones, Russell G., Pollak, Michael, Delattre, Olivier, Gleave, Martin E., Jan, Eric, Pfister, Stefan M., Proud, Christopher G., Derry, W. Brent, Taylor, Michael D., Sorensen, Poul H.

“…Metabolic adaptation is essential for cell survival during nutrient deprivation. We report that eukaryotic elongation factor 2 kinase (eEF2K), which is…”
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Quiescent Sox2+ Cells Drive Hierarchical Growth and Relapse in Sonic Hedgehog Subgroup Medulloblastoma by Vanner, Robert J., Remke, Marc, Gallo, Marco, Selvadurai, Hayden J., Coutinho, Fiona, Lee, Lilian, Kushida, Michelle, Head, Renee, Morrissy, Sorana, Zhu, Xueming, Aviv, Tzvi, Voisin, Veronique, Clarke, Ian D., Li, Yisu, Mungall, Andrew J., Moore, Richard A., Ma, Yussanne, Jones, Steven J.M., Marra, Marco A., Malkin, David, Northcott, Paul A., Kool, Marcel, Pfister, Stefan M., Bader, Gary, Hochedlinger, Konrad, Korshunov, Andrey, Taylor, Michael D., Dirks, Peter B.

“…Functional heterogeneity within tumors presents a significant therapeutic challenge. Here we show that quiescent, therapy-resistant Sox2+ cells propagate sonic…”
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scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy by Ocasio, Jennifer Karin, Babcock, Benjamin, Malawsky, Daniel, Weir, Seth J., Loo, Lipin, Simon, Jeremy M., Zylka, Mark J., Hwang, Duhyeong, Dismuke, Taylor, Sokolsky, Marina, Rosen, Elias P., Vibhakar, Rajeev, Zhang, Jiao, Saulnier, Olivier, Vladoiu, Maria, El-Hamamy, Ibrahim, Stein, Lincoln D., Taylor, Michael D., Smith, Kyle S., Northcott, Paul A., Colaneri, Alejandro, Wilhelmsen, Kirk, Gershon, Timothy R.

“…Targeting oncogenic pathways holds promise for brain tumor treatment, but inhibition of Sonic Hedgehog (SHH) signaling has failed in SHH-driven…”
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Concise Review of Nickel Human Health Toxicology and Ecotoxicology by Buxton, Samuel, Garman, Emily, Heim, Katherine E., Lyons-Darden, Tara, Schlekat, Christian E., Taylor, Michael D., Oller, Adriana R.

“…Nickel (Ni) metal and Ni compounds are widely used in applications like stainless steel, alloys, and batteries. Nickel is a naturally occurring element in…”
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The Transition from Quiescent to Activated States in Human Hematopoietic Stem Cells Is Governed by Dynamic 3D Genome Reorganization by Takayama, Naoya, Murison, Alex, Takayanagi, Shin-ichiro, Arlidge, Christopher, Zhou, Stanley, Garcia-Prat, Laura, Chan-Seng-Yue, Michelle, Zandi, Sasan, Gan, Olga I., Boutzen, Héléna, Kaufmann, Kerstin B., Trotman-Grant, Aaron, Schoof, Erwin, Kron, Ken, Díaz, Noelia, Lee, John J.Y., Medina, Tiago, De Carvalho, Daniel D., Taylor, Michael D., Vaquerizas, Juan M., Xie, Stephanie Z., Dick, John E., Lupien, Mathieu

“…Lifelong blood production requires long-term hematopoietic stem cells (LT-HSCs), marked by stemness states involving quiescence and self-renewal, to transition…”
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Eplerenone for early cardiomyopathy in Duchenne muscular dystrophy: a randomised, double-blind, placebo-controlled trial by Raman, Subha V, Dr, Hor, Kan N, MD, Mazur, Wojciech, MD, Halnon, Nancy J, MD, Kissel, John T, MD, He, Xin, PhD, Tran, Tam, BS, Smart, Suzanne, BS, McCarthy, Beth, RT, Taylor, Michael D, MD, Jefferies, John L, MD, Rafael-Fortney, Jill A, PhD, Lowe, Jeovanna, MS, Roble, Sharon L, MD, Cripe, Linda H, MD

“…Summary Background Cardiomyopathy is a leading cause of death in patients with Duchenne muscular dystrophy and myocardial damage precedes decline in left…”
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