Search Results - "Taylor, Merry"

Discovery of Potent and Selective SH2 Inhibitors of the Tyrosine Kinase ZAP-70 by Vu, Chi B, Corpuz, Evelyn G, Merry, Taylor J, Pradeepan, Selvaluxmi G, Bartlett, Catherine, Bohacek, Regine S, Botfield, Martyn C, Eyermann, Charles J, Lynch, Berkley A, MacNeil, Ian A, Ram, Mary K, van Schravendijk, Marie Rose, Violette, Shelia, Sawyer, Tomi K

“…A series of 1,2,4-oxadiazole analogues has been shown to be potent and selective SH2 inhibitors of the tyrosine kinase ZAP-70, a potential therapeutic target…”
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Early Point-of-Care Testing at Triage Reduces Care Time in Stable Adult Emergency Department Patients by Singer, Adam J., Taylor, Merry, LeBlanc, Deborah, Meyers, Kristen, Perez, Karol, Thode, Henry C., Pines, Jesse M.

“…Core laboratory testing may increase length of stay and delay care. We compared length of emergency department (ED) care in patients receiving point-of-care…”
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Diagnostic Characteristics of a Clinical Screening Tool in Combination With Measuring Bedside Lactate Level in Emergency Department Patients With Suspected Sepsis by Singer, Adam J., Taylor, Merry, Domingo, Anna, Ghazipura, Saad, Khorasonchi, Adam, Thode, Henry C., Shapiro, Nathan I., Jang, Timothy

“…Background Early identification of sepsis and initiation of aggressive treatment saves lives. However, the diagnosis of sepsis may be delayed in patients…”
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Structure-Based Design of an Osteoclast-Selective, Nonpeptide Src Homology 2 Inhibitor with in vivo Antiresorptive Activity by Shakespeare, William, Yang, Michael, Bohacek, Regine, Cerasoli, Franklin, Stebbins, Karin, Sundaramoorthi, Raji, Azimioara, Mihai, Vu, Chi, Pradeepan, Selvi, Metcalf, Chester, Haraldson, Chad, Merry, Taylor, Dalgarno, David, Narula, Surinder, Hatada, Marcos, Lu, Xiaode, van Schravendijk, Marie Rose, Adams, Susan, Violette, Shelia, Smith, Jeremy, Guan, Wei, Bartlett, Catherine, Herson, Jay, Iuliucci, John, Weigele, Manfred, Sawyer, Tomi

“…Targeted disruption of the pp60src(Src) gene has implicated this tyrosine kinase in osteoclast-mediated bone resorption and as a therapeutic target for the…”
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Bone-Targeted Src kinase inhibitors: novel pyrrolo- and pyrazolopyrimidine analogues by Sundaramoorthi, Raji, Shakespeare, William C., Keenan, Terence P., Metcalf, Chester A., Wang, Yihan, Mani, Ukti, Taylor, Merry, Liu, Shuangying, Bohacek, Regine S., Narula, Surinder S., Dalgarno, David C., Van Schravandijk, Marie Rose, Violette, Sheila M., Liou, Shuenn, Adams, Susan, Ram, Mary K., Keats, Jeffrey A., Weigele, Manfred, Sawyer, Tomi K.

“…Src tyrosine kinase is a therapeutic target for bone diseases that has been validated by gene knockout studies. Furthermore, in vitro cellular studies…”
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X-ray Structure of Citrate Bound to Src SH2 Leads to a High-Affinity, Bone-Targeted Src SH2 Inhibitor by Bohacek, Regine S, Dalgarno, David C, Hatada, Marcos, Jacobsen, Virginia A, Lynch, Berkley A, Macek, Karina J, Merry, Taylor, Metcalf, Chester A, Narula, Surinder S, Sawyer, Tomi K, Shakespeare, William C, Violette, Shelia M, Weigele, Manfred

“…Numerous studies provide compelling evidence that the protein tyrosine kinase pp60 super(c-Src) (Src) plays a crucial role in osteoclast-mediated bone…”
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Bone-Targeted pyrido[2,3- d]pyrimidin-7-ones: potent inhibitors of Src tyrosine kinase as novel antiresorptive agents by Vu, Chi B., Luke, George P., Kawahata, Noriyuki, Shakespeare, William C., Wang, Yihan, Sundaramoorthi, Raji, Metcalf, Chester A., Keenan, Terence P., Pradeepan, Selvi, Corpuz, Evelyn, Merry, Taylor, Bohacek, Regine S., Dalgarno, David C., Narula, Surinder S., van Schravendijk, Marie Rose, Ram, Mary K., Adams, Susan, Liou, Shuenn, Keats, Jeffrey A., Violette, Shelia M., Guan, Wei, Weigele, Manfred, Sawyer, Tomi K.

“…The design of bone-targeted pyrido[2,3- d]pyrimidin-7-ones as Src tyrosine kinase inhibitors is described. Leveraging SAR from known compounds and using…”
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Structure-based design of novel nonpeptide inhibitors of the Src SH2 domain: Phosphotyrosine mimetics exploiting multifunctional group replacement chemistry by Sundaramoorthi, Raji, Kawahata, Noriyuki, Yang, Michael G., Shakespeare, William C., Metcalf III, Chester A., Wang, Yihan, Merry, Taylor, Eyermann, Charles J., Bohacek, Regine S., Narula, Surinder, Dalgarno, David C., Sawyer, Tomi K.

“…A series of novel nonpeptide inhibitors of the pp60c‐Src (Src) SH2 domain is described that exploit multifunctional group replacement of the phenylphosphate…”
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Structure-activity relationships of a novel class of Src SH2 inhibitors by Buchanan, John L., Vu, Chi B., Merry, Taylor J., Corpuz, Evelyn G., Pradeepan, Selvaluxmi G., Mani, Ukti N., Yang, Michael, Plake, Hilary R., Varkhedkar, Vaibhav M., Lynch, Berkley A., MacNeil, Ian A., Loiacono, Kara A., Tiong, Choi Lai, Holt, Dennis A.

“…The structure-activity relationships (SAR) of a novel class of Src SH2 inhibitors are described. Variation at the pY+1 and pY+3 side chain positions using 2,4-…”
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A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp): exploitation in the design of nonpeptide inhibitors of pp60(Src) SH2 domain by Kawahata, N, Yang, M G, Luke, G P, Shakespeare, W C, Sundaramoorthi, R, Wang, Y, Johnson, D, Merry, T, Violette, S, Guan, W, Bartlett, C, Smith, J, Hatada, M, Lu, X, Dalgarno, D C, Eyermann, C J, Bohacek, R S, Sawyer, T K

“…The novel phosphotyrosine (pTyr) mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp) has been designed and incorporated into a series of nonpeptide…”
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Corrigendum to “Bone-Targeted Src Kinase Inhibitors: Novel Pyrrolo- and Pyrazolopyrimidine Analogues”[Bioorg. Med. Chem. Lett. 13 (2003) 3063] by Sundaramoorthi, Raji, Shakespeare, William C, Keenan, Terence P, Metcalf, Chester A, Wang, Yihan, Mani, Ukti, Merry, Taylor, Liu, Shuangying, Bohacek, Regine S, Narula, Surinder S, Dalgarno, David C, Van Schravendijk, Marie Rose, Violette, Shelia M, Liou, Shuenn, Adams, Susan, Ram, Mary K, Keats, Jeffrey A, Weigle, Manfred, Sawyer, Tomi K

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Bone-targeted Src kinase inhibitors: Novel pyrrolo- and pyrazolopyrimidine analogues: Recent advances in the design of kinase inhibitors as novel therapeutic agents by SUNDARAMOORTHI, Raji, SHAKESPEARE, William C, DALGARNO, David C, VAN SCHRAVANDIJK, Marie Rose, VIOLETTE, Sheila M, LIOU, Shuenn, ADAMS, Susan, RAM, Mary K, KEATS, Jeffrey A, WEIGELE, Manfred, SAWYER, Tomi K, KEENAN, Terence P, METCALF, Chester A, YIHAN WANG, MANI, Ukti, TAYLOR, Merry, SHUANGYING LIU, BOHACEK, Regine S, NARULA, Surinder S

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A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp) : Exploitation in the design of nonpeptide inhibitors of pp60Src SH2 domain by KAWAHATA, Noriyuki, YANG, Michael G, BARTLETT, Catherine, SMITH, Jeremy, HATADA, Marcos, XIAODE LU, DALGARNO, David C, EYERMANN, Charles J, BOHACEK, Regine S, SAWYER, Tomi K, LUKE, George P, SHAKESPEARE, William C, SUNDARAMOORTHI, Raji, YIHAN WANG, JOHNSON, Daniel, MERRY, Taylor, VIOLETTE, Shelia, WEI GUAN

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A novel phosphotyrosine mimetic 4′-carboxymethyloxy-3′-phosphonophenylalanine (cpp): exploitation in the design of nonpeptide inhibitors of pp60 Src SH2 domain by Kawahata, Noriyuki, Yang, Michael G., Luke, George P., Shakespeare, William C., Sundaramoorthi, Raji, Wang, Yihan, Johnson, Daniel, Merry, Taylor, Violette, Shelia, Guan, Wei, Bartlett, Catherine, Smith, Jeremy, Hatada, Marcos, Lu, Xiaode, Dalgarno, David C., Eyermann, Charles J., Bohacek, Regine S., Sawyer, Tomi K.

“…The novel phosphotyrosine (pTyr) mimetic 4′-carboxymethyloxy-3′-phosphonophenylalanine (Cpp) has been designed and incorporated into a series of nonpeptide…”
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Novel phosphate ester-linked resins: The solid-phase generation of phenyl phosphate-containing compounds for SH2 inhibition by Metcalf, Chester A., Vu, Chi B., Sundaramoorthi, Raji, Jacobsen, Virginia A., Laborde, Edgardo A., Green, Jeremy, Green, Yinka, Macek, Karina J., Merry, Taylor J., Pradeepan, Selvi G., Uesugi, Mayumi, Varkhedkar, Vaibhav M., Holt, Dennis A.

“…An efficient method for the preparation of protected phosphate ester-linked resins in high yield and purity is presented. Variation in tether…”
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Bone-targeted pyrido[2,3-d]pyrimidin-7-ones: Potent inhibitors of Src tyrosine kinase as novel antiresorptive agents: Recent advances in the design of kinase inhibitors as novel therapeutic agents by VU, Chi B, LUKE, George P, MERRY, Taylor, BOHACEK, Regine S, DALGARNO, David C, NARULA, Surinder S, VAN SCHRAVENDIJK, Marie Rose, RAM, Mary K, ADAMS, Susan, LIOU, Shuenn, KEATS, Jeffrey A, VIOLETTE, Shelia M, KAWAHATA, Noriyuki, WEI GUAN, WEIGELE, Manfred, SAWYER, Tomi K, SHAKESPEARE, William C, YIHAN WANG, SUNDARAMOORTHI, Raji, METCALF, Chester A, KEENAN, Terence P, PRADEEPAN, Selvi, CORPUZ, Evelyn

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