Search Results - "Taylor, Matthew"
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A survey and critique of multiagent deep reinforcement learning
Published in Autonomous agents and multi-agent systems (01-11-2019)“…Deep reinforcement learning (RL) has achieved outstanding results in recent years. This has led to a dramatic increase in the number of applications and…”
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Genetics of Dilated Cardiomyopathy
Published in Annual review of medicine (29-01-2024)“…Dilated cardiomyopathy (DCM) is defined as dilation and or reduced function of one or both ventricles and remains a common disease worldwide. An estimated 40%…”
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DNA Damage Response/TP53 Pathway Is Activated and Contributes to the Pathogenesis of Dilated Cardiomyopathy Associated With LMNA (Lamin A/C) Mutations
Published in Circulation research (15-03-2019)“…RATIONALE:Mutations in the LMNA gene, encoding LMNA (lamin A/C), are responsible for laminopathies. Dilated cardiomyopathy (DCM) is a major cause of mortality…”
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Injectable Hydrogels for Cardiac Tissue Engineering
Published in Macromolecular bioscience (01-06-2018)“…In light of the limited efficacy of current treatments for cardiac regeneration, tissue engineering approaches have been explored for their potential to…”
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Animal size impacts perfluoroalkyl acid (PFAA) concentrations in muscle tissue of estuarine fish and invertebrate species
Published in Environmental pollution (1987) (01-12-2020)“…Environmental emissions of perfluoroalkyl acids (PFAAs) often contaminate aquatic ecosystems and accumulate in the species therein. This can represent an…”
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Genetic Risk of Arrhythmic Phenotypes in Patients With Dilated Cardiomyopathy
Published in Journal of the American College of Cardiology (17-09-2019)“…Genotype-phenotype correlations in dilated cardiomyopathy (DCM) and, in particular, the effects of gene variants on clinical outcomes remain poorly understood…”
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Metal concentrations in the edible claw and body muscle of a popular recreational crab species (Scylla serrata)
Published in Marine pollution bulletin (01-12-2023)“…In crabs, metal concentrations differ among tissues, but may also differ in edible white meat (muscle) in different parts of the body. This case study compared…”
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Perfluoroalkyl acid depuration from the edible tissues of a migratory recreationally fished species
Published in Marine pollution bulletin (01-11-2023)“…Environmental emissions of perfluoroalkyl acids (PFAAs) impact estuarine species and the fisheries that rely on them. Migratory estuarine fishes may be…”
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Transcriptome analysis of human heart failure reveals dysregulated cell adhesion in dilated cardiomyopathy and activated immune pathways in ischemic heart failure
Published in BMC genomics (12-11-2018)“…Current heart failure (HF) treatment is based on targeting symptoms and left ventricle dysfunction severity, relying on a common HF pathway paradigm to justify…”
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Trends in Off-Label Drug Use in Ambulatory Settings: 2006-2015
Published in Pediatrics (Evanston) (01-10-2019)“…Off-label drug use in children is common and potentially harmful. In most previous off-label use research, authors studied hospitalized children, specific drug…”
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Advances in elucidating the function of leucine-rich repeat protein kinase-2 in normal cells and Parkinson's disease
Published in Current opinion in cell biology (01-04-2020)“…Autosomal dominant missense mutations that hyperactivate the leucine-rich repeat protein kinase-2 (LRRK2) are a common cause of inherited Parkinson's disease…”
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SCN5A Mutations Associate With Arrhythmic Dilated Cardiomyopathy and Commonly Localize to the Voltage-Sensing Mechanism
Published in Journal of the American College of Cardiology (24-05-2011)“…Objectives The aim of this study was to discern the role of the cardiac voltage-gated sodium ion channel SCN5A in the etiology of dilated cardiomyopathy (DCM)…”
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Nrf2 signaling in heart failure: expression of Nrf2, Keap1, antioxidant, and detoxification genes in dilated or ischemic cardiomyopathy
Published in Physiological genomics (01-03-2022)“…Increased levels of oxidative stress have been found with heart failure. Whether failing hearts express antioxidant and detoxification enzymes have not been…”
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Survey design for quantifying perfluoroalkyl acid concentrations in fish, prawns and crabs to assess human health risks
Published in The Science of the total environment (20-02-2019)“…Per and polyfluoroalkyl substances (PFASs) are emerging contaminants that have potential implications for human health. Perfluorooctane sulfonate (PFOS) and…”
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The 2019 US medical genetics workforce: a focus on clinical genetics
Published in Genetics in medicine (01-08-2021)“…This study characterizes the US clinical genetics workforce to inform workforce planning and public policy development. A 32-question survey was electronically…”
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Genetic Evaluation of Cardiomyopathy—A Heart Failure Society of America Practice Guideline
Published in Journal of cardiac failure (01-05-2018)“…This guideline describes the approach and expertise needed for the genetic evaluation of cardiomyopathy. First published in 2009 by the Heart Failure Society…”
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The inverse relationship between farm size and productivity: Refocusing the debate
Published in Food policy (01-02-2021)“…•Agricultural productivity matters for poverty reduction and growth.•Land productivity declines with farm size in all regions of Brazil.•The farm size – total…”
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Can We Chat . . . Privately? Using Twitter Chats to Facilitate Offline Engagement for Nonprofits
Published in Nonprofit and voluntary sector quarterly (01-06-2023)“…This study examines a health-focused nonprofit organization’s Twitter chats, using qualitative content analysis and social network analysis (SNA) to describe…”
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The Giant Protein Titin's Role in Cardiomyopathy: Genetic, Transcriptional, and Post-translational Modifications of TTN and Their Contribution to Cardiac Disease
Published in Frontiers in physiology (28-11-2019)“…Dilated cardiomyopathy (DCM) is a leading cause of heart failure, sudden cardiac death and heart transplant. DCM is inherited in approximately 50% of cases, in…”
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Computer Programming With Pre-K Through First-Grade Students With Intellectual Disabilities
Published in The Journal of special education (01-08-2018)“…Researchers suggest students in early elementary grade levels are active learners and creators and need to be exposed to science, technology, engineering, and…”
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