Search Results - "Taylor, Martin S."

Enzymatic Removal of Ribonucleotides from DNA Is Essential for Mammalian Genome Integrity and Development by Reijns, Martin A.M., Rabe, Björn, Rigby, Rachel E., Mill, Pleasantine, Astell, Katy R., Lettice, Laura A., Boyle, Shelagh, Leitch, Andrea, Keighren, Margaret, Kilanowski, Fiona, Devenney, Paul S., Sexton, David, Grimes, Graeme, Holt, Ian J., Hill, Robert E., Taylor, Martin S., Lawson, Kirstie A., Dorin, Julia R., Jackson, Andrew P.

“…The presence of ribonucleotides in genomic DNA is undesirable given their increased susceptibility to hydrolysis. Ribonuclease (RNase) H enzymes that recognize…”
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Affinity Proteomics Reveals Human Host Factors Implicated in Discrete Stages of LINE-1 Retrotransposition by Taylor, Martin S., LaCava, John, Mita, Paolo, Molloy, Kelly R., Huang, Cheng Ran Lisa, Li, Donghui, Adney, Emily M., Jiang, Hua, Burns, Kathleen H., Chait, Brian T., Rout, Michael P., Boeke, Jef D., Dai, Lixin

“…LINE-1s are active human DNA parasites that are agents of genome dynamics in evolution and disease. These streamlined elements require host factors to complete…”
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Variant detection sensitivity and biases in whole genome and exome sequencing by Meynert, Alison M, Ansari, Morad, FitzPatrick, David R, Taylor, Martin S

“…Less than two percent of the human genome is protein coding, yet that small fraction harbours the majority of known disease causing mutations. Despite rapidly…”
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Lagging-strand replication shapes the mutational landscape of the genome by Reijns, Martin A. M., Kemp, Harriet, Ding, James, Marion de Procé, Sophie, Jackson, Andrew P., Taylor, Martin S.

“…The origin of mutations is central to understanding evolution and of key relevance to health. Variation occurs non-randomly across the genome, and mechanisms…”
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EWSR1/FUS-NFATc2 rearranged round cell sarcoma: clinicopathological series of 4 cases and literature review by Diaz-Perez, Julio A., Nielsen, G. Petur, Antonescu, Cristina, Taylor, Martin S., Lozano-Calderon, Santiago A., Rosenberg, Andrew E.

“…The classification of bone neoplasms composed of small round cells is experiencing a transformation after the discovery of various gene fusion rearrangements…”
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Nitrogen and oxygen isotopic fractionation during microbial nitrite reduction by Martin, Taylor S., Casciotti, Karen L.

“…Microbial nitrite reduction plays an important role in the nitrogen cycle, producing the first gaseous product in the denitrification pathway. The role of…”
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Bidirectional transcription initiation marks accessible chromatin and is not specific to enhancers by Young, Robert S, Kumar, Yatendra, Bickmore, Wendy A, Taylor, Martin S

“…Enhancers are modular regulatory elements that are central to the spatial and temporal regulation of gene expression. Bidirectional transcription initiating at…”
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Mutational Biases Drive Elevated Rates of Substitution at Regulatory Sites across Cancer Types by Kaiser, Vera B, Taylor, Martin S, Semple, Colin A

“…Disruption of gene regulation is known to play major roles in carcinogenesis and tumour progression. Here, we comprehensively characterize the mutational…”
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High Prevalence and Disease Correlation of Autoantibodies Against p40 Encoded by Long Interspersed Nuclear Elements in Systemic Lupus Erythematosus by Carter, Victoria, LaCava, John, Taylor, Martin S., Liang, Shu Ying, Mustelin, Cecilia, Ukadike, Kennedy C., Bengtsson, Anders, Lood, Christian, Mustelin, Tomas

“…Objective Long interspersed nuclear element 1 (LINE‐1) encodes 2 proteins, the RNA binding protein p40 and endonuclease and reverse transcriptase (open‐reading…”
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Retrotransposon insertions in the clonal evolution of pancreatic ductal adenocarcinoma by Rodić, Nemanja, Steranka, Jared P, Makohon-Moore, Alvin, Moyer, Allison, Shen, Peilin, Sharma, Reema, Kohutek, Zachary A, Huang, Cheng Ran, Ahn, Daniel, Mita, Paolo, Taylor, Martin S, Barker, Norman J, Hruban, Ralph H, Iacobuzio-Donahue, Christine A, Boeke, Jef D, Burns, Kathleen H

“…The authors find that alterations in retrotransposition can occur at different stages in the evolution of pancreatic adenocarcinoma. Pancreatic ductal…”
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The contribution of evolutionarily volatile promoters to molecular phenotypes and human trait variation by Young, Robert S, Talmane, Lana, Marion de Procé, Sophie, Taylor, Martin S

“…Promoters are sites of transcription initiation that harbour a high concentration of phenotype-associated genetic variation. The evolutionary gain and loss of…”
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Cell-free DNA captures tumor heterogeneity and driver alterations in rapid autopsies with pre-treated metastatic cancer by Pereira, Bernard, Chen, Christopher T., Goyal, Lipika, Walmsley, Charlotte, Pinto, Christopher J., Baiev, Islam, Allen, Read, Henderson, Laura, Saha, Supriya, Reyes, Stephanie, Taylor, Martin S., Fitzgerald, Donna M., Broudo, Maida Williams, Sahu, Avinash, Gao, Xin, Winckler, Wendy, Brannon, A. Rose, Engelman, Jeffrey A., Leary, Rebecca, Stone, James R., Campbell, Catarina D., Juric, Dejan

“…In patients with metastatic cancer, spatial heterogeneity of somatic alterations may lead to incomplete assessment of a cancer’s mutational profile when…”
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Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages by Schroder, Kate, Irvine, Katharine M., Taylor, Martin S., Bokil, Nilesh J., Le Cao, Kim-Anh, Masterman, Kelly-Anne, Labzin, Larisa I., Semple, Colin A., Kapetanovic, Ronan, Fairbairn, Lynsey, Akalin, Altuna, Faulkner, Geoffrey J., Baillie, John Kenneth, Gongora, Milena, Daub, Carsten O., Kawaji, Hideya, McLachlan, Geoffrey J., Goldman, Nick, Grimmond, Sean M., Carninci, Piero, Suzuki, Harukazu, Hayashizaki, Yoshihide, Lenhard, Boris, Hume, David A., Sweet, Matthew J.

“…Evolutionary change in gene expression is generally considered to be a major driver of phenotypic differences between species. We investigated innate immune…”
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Heterozygous Loss-of-Function Mutations in YAP1 Cause Both Isolated and Syndromic Optic Fissure Closure Defects by Williamson, Kathleen A., Rainger, Joe, Floyd, James A.B., Ansari, Morad, Meynert, Alison, Aldridge, Kishan V., Rainger, Jacqueline K., Anderson, Carl A., Moore, Anthony T., Hurles, Matthew E., Clarke, Angus, van Heyningen, Veronica, Verloes, Alain, Taylor, Martin S., Wilkie, Andrew O.M., FitzPatrick, David R.

“…Exome sequence analysis of affected individuals from two families with autosomal-dominant inheritance of coloboma identified two different cosegregating…”
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Evolution of the human-specific microRNA miR-941 by Hu, Hai Yang, He, Liu, Fominykh, Kseniya, Yan, Zheng, Guo, Song, Zhang, Xiaoyu, Taylor, Martin S., Tang, Lin, Li, Jie, Liu, Jianmei, Wang, Wen, Yu, Haijing, Khaitovich, Philipp

“…MicroRNA-mediated gene regulation is important in many physiological processes. Here we explore the roles of a microRNA, miR-941, in human evolution. We find…”
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Dinosaur Body Temperatures Determined from Isotopic ( 13 C- 18 O) Ordering in Fossil Biominerals by Eagle, Robert A., Tütken, Thomas, Martin, Taylor S., Tripati, Aradhna K., Fricke, Henry C., Connely, Melissa, Cifelli, Richard L., Eiler, John M.

“…The nature of the physiology and thermal regulation of the nonavian dinosaurs is the subject of debate. Previously, arguments have been made for both…”
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Codon Usage and Splicing Jointly Influence mRNA Localization by Mordstein, Christine, Savisaar, Rosina, Young, Robert S, Bazile, Jeanne, Talmane, Lana, Luft, Juliet, Liss, Michael, Taylor, Martin S, Hurst, Laurence D, Kudla, Grzegorz

“…In the human genome, most genes undergo splicing, and patterns of codon usage are splicing dependent: guanine and cytosine (GC) content is the highest within…”
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Orthotopic and heterotopic murine models of pancreatic cancer and their different responses to FOLFIRINOX chemotherapy by Erstad, Derek J, Sojoodi, Mozhdeh, Taylor, Martin S, Ghoshal, Sarani, Razavi, Allen A, Graham-O'Regan, Katherine A, Bardeesy, Nabeel, Ferrone, Cristina R, Lanuti, Michael, Caravan, Peter, Tanabe, Kenneth K, Fuchs, Bryan C

“…Syngeneic, immunocompetent allograft tumor models recapitulate important aspects of the tumor microenvironment and have short tumor latency with predictable…”
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Novel and established EWSR1 gene fusions and associations identified by next-generation sequencing and fluorescence in-situ hybridization by Krystel-Whittemore, Melissa, Taylor, Martin S., Rivera, Miguel, Lennerz, Jochen K., Le, Long P., Dias-Santagata, Dora, Iafrate, Anthony John, Deshpande, Vikram, Chebib, Ivan, Nielsen, Gunnlaugur Petur, Wu, Chin-Lee, Nardi, Valentina

“…EWSR1 is a ‘promiscuous’ gene that can fuse with many different partner genes in phenotypically identical tumors or partner with the same genes in…”
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Comparative transcriptomics of primary cells in vertebrates by Alam, Tanvir, Agrawal, Saumya, Severin, Jessica, Young, Robert S, Andersson, Robin, Arner, Erik, Hasegawa, Akira, Lizio, Marina, Ramilowski, Jordan A, Abugessaisa, Imad, Ishizu, Yuri, Noma, Shohei, Tarui, Hiroshi, Taylor, Martin S, Lassmann, Timo, Itoh, Masayoshi, Kasukawa, Takeya, Kawaji, Hideya, Marchionni, Luigi, Sheng, Guojun, R R Forrest, Alistair, Khachigian, Levon M, Hayashizaki, Yoshihide, Carninci, Piero, de Hoon, Michiel J L

“…Gene expression profiles in homologous tissues have been observed to be different between species, which may be due to differences between species in the gene…”
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