Search Results - "Taylor, Kirk a"

Edi(torial) 2024: action plan for change and new initiatives by Taylor, Kirk A

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EDI(torial): equality, diversity, and inclusion and platelets - 2021 by Taylor, Kirk A.

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Mind the gap: connexins and pannexins in platelet function by Taylor, Kirk a, Little, Gemma, Gibbins, Jonathan M.

“…Connexins are a family of gap junction forming proteins widely expressed by mammalian cells. They assemble into hexameric hemichannels, which can either…”
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Ion channels and ion homeostasis in the platelet and megakaryocyte by Taylor, Kirk A., Mahaut-Smith, Martyn P.

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Delineating Zinc Influx Mechanisms during Platelet Activation by Kuravi, Sahithi J, Ahmed, Niaz S, Taylor, Kirk A, Capes, Emily M, Bye, Alex, Unsworth, Amanda J, Gibbins, Jonathan M, Pugh, Nicholas

“…Zinc (Zn ) is released by platelets during a hemostatic response to injury. Extracellular zinc ([Zn ] ) initiates platelet activation following influx into the…”
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A major interspecies difference in the ionic selectivity of megakaryocyte Ca2+-activated channels sensitive to the TMEM16F inhibitor CaCCinh-A01 by Taylor, Kirk A., Mahaut-Smith, Martyn P.

“…TMEM16F is a surface membrane protein critical for platelet procoagulant activity, which exhibits both phospholipid scramblase and ion channel activities…”
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Fully automated platelet differential interference contrast image analysis via deep learning by Kempster, Carly, Butler, George, Kuznecova, Elina, Taylor, Kirk A., Kriek, Neline, Little, Gemma, Sowa, Marcin A., Sage, Tanya, Johnson, Louise J., Gibbins, Jonathan M., Pollitt, Alice Y.

“…Platelets mediate arterial thrombosis, a leading cause of myocardial infarction and stroke. During injury, platelets adhere and spread over exposed…”
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Blood and Bone: The quarantine chronicles by Taylor, Kirk A., Machlus, Kellie R.

“…In the midst of the chaos of the global pandemic, the online daily webinar series Blood and Bone was created. The series started with a blank schedule on a…”
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Regulation of Pannexin-1 channel activity by Taylor, Kirk A, Wright, Joy R, Mahaut-Smith, Martyn P

“…Pannexin-1 (Panx1) forms anion-selective channels with a permeability up to 1 kDa and represents a pathway for the release of cytosolic ATP. Several…”
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Refinement of a mouse cardiovascular model: Development, application and dissemination [version 1; peer review: 2 approved, 1 approved with reservations] by Taylor, Kirk A, Emerson, Michael

“…European and UK legislation requires all animal procedures to be conducted with consideration to reduction, refinement and replacement. In this review, 3Rs…”
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Extracellular chloride is required for efficient platelet aggregation by Taylor, Kirk A., Wilson, Darren G. S., Harper, Matthew T., Pugh, Nicholas

“…Anion channels perform a diverse range of functions and have been implicated in ATP release, volume regulation, and phosphatidylserine exposure. Platelets have…”
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Harnessing Twitter to empower scientific engagement and communication: The ISTH 2020 virtual congress experience by Othman, Maha, Cormier, Matthew, Barnes, Geoffrey D., Comer, Shane P., Connors, Jean M., Denorme, Frederik, Khorana, Alok A., Las Casas, Pedro Henrique, Morla, Shravan, Muia, Joshua, Ní Áinle, Fionnuala, Taylor, Kirk A., van der Wal, Dianne E., Weyand, Angela C., Lavin, Michelle

“…As a result of the coronavirus disease 2019 pandemic, the International Society on Thrombosis and Haemostasis (ISTH), like many societies around the world,…”
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HIV Antivirals Affect Endothelial Activation and Endothelial-Platelet Crosstalk by Khawaja, Akif A., Taylor, Kirk A., Lovell, Andrew O., Nelson, Mark, Gazzard, Brian, Boffito, Marta, Emerson, Michael

“…RATIONALE:People living with HIV on effective antiretroviral therapy are at increased risk of cardiovascular complications, possibly due to off-target drug…”
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Pharmacological impact of antiretroviral therapy on platelet function to investigate human immunodeficiency virus‐associated cardiovascular risk by Taylor, Kirk A., Smyth, Erica, Rauzi, Francesca, Cerrone, Maddalena, Khawaja, Akif A., Gazzard, Brian, Nelson, Mark, Boffito, Marta, Emerson, Michael

“…Background and purpose Some clinical studies have reported increased myocardial infarction in people living with human immunodeficiency virus (HIV) taking the…”
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The rate of platelet activation determines thrombus size and structure at arterial shear by Mitchell, Joanne L., Dunster, Joanne L., Kriek, Neline, Unsworth, Amanda J., Sage, Tanya, Mohammed, Yasmin M.M., De Simone, Ilaria, Taylor, Kirk A., Bye, Alexander P., Ólafsson, Geir, Brunton, Mark, Mark, Sharon, Dymott, Leanne D., Whyte, Abigail, Ruparelia, Neil, Mckenna, Charlie, Gibbins, Jonathan M., Jones, Christopher I.

“…The response of platelets to activating stimuli and pharmaceutical agents varies greatly within the normal population. Current platelet function tests are used…”
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A major interspecies difference in the ionic selectivity of megakaryocyte Ca 2+ -activated channels sensitive to the TMEM16F inhibitor CaCCinh-A01 by Taylor, Kirk A, Mahaut-Smith, Martyn P

“…TMEM16F is a surface membrane protein critical for platelet procoagulant activity, which exhibits both phospholipid scramblase and ion channel activities…”
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Agonist-Evoked Increases in Intra-Platelet Zinc Couple to Functional Responses by Ahmed, Niaz S, Lopes Pires, Maria E, Taylor, Kirk A, Pugh, Nicholas

“…Zinc (Zn ) is an essential trace element that regulates intracellular processes in multiple cell types. While the role of Zn as a platelet agonist is known,…”
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The isothiocyanate sulforaphane modulates platelet function and protects against cerebral thrombotic dysfunction by Gillespie, Scarlett, Holloway, Paul M, Becker, Felix, Rauzi, Francesca, Vital, Shantel A, Taylor, Kirk A, Stokes, Karen Y, Emerson, Michael, Gavins, Felicity N E

“…Background and Purpose Platelet activation provides a critical link between inflammation and thrombosis. Sulforaphane (SFN), a naturally occurring…”
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Fibrinogen-mimicking, multiarm nanovesicles for human thrombus-specific delivery of tissue plasminogen activator and targeted thrombolytic therapy by Huang, Yu, Gu, Boram, Salles-Crawley, Isabelle I, Taylor, Kirk A, Yu, Li, Ren, Jie, Liu, Xuhan, Emerson, Michael, Longstaff, Colin, Hughes, Alun D, Thom, Simon A, Xu, Xiao Yun, Chen, Rongjun

“…Clinical use of tissue plasminogen activator (tPA) in thrombolytic therapy is limited by its short circulation time and hemorrhagic side effects. Inspired by…”
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Calcium Signalling through Ligand-Gated Ion Channels such as P2X1 Receptors in the Platelet and other Non-Excitable Cells by Mahaut-Smith, Martyn P, Taylor, Kirk A, Evans, Richard J

“…Ligand-gated ion channels on the cell surface are directly activated by the binding of an agonist to their extracellular domain and often referred to as…”
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