Search Results - "Taylor, Ian A."

Structural basis of dimerization and dual W-box DNA recognition by rice WRKY domain by Cheng, Xiankun, Zhao, Yanxiang, Jiang, Qingshan, Yang, Jun, Zhao, Wensheng, Taylor, Ian A, Peng, You-Liang, Wang, Dongli, Liu, Junfeng

“…Abstract In rice, the critical regulator of the salicylic acid signalling pathway is OsWRKY45, a transcription factor (TF) of the WRKY TF family that functions…”
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The speed of GTP hydrolysis determines GTP cap size and controls microtubule stability by Roostalu, Johanna, Thomas, Claire, Cade, Nicholas Ian, Kunzelmann, Simone, Taylor, Ian A, Surrey, Thomas

“…Microtubules are cytoskeletal polymers whose function depends on their property to switch between states of growth and shrinkage. Growing microtubules are…”
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A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets by Hobor, Fruzsina, Dallmann, Andre, Ball, Neil J., Cicchini, Carla, Battistelli, Cecilia, Ogrodowicz, Roksana W., Christodoulou, Evangelos, Martin, Stephen R., Castello, Alfredo, Tripodi, Marco, Taylor, Ian A., Ramos, Andres

“…Exosomal miRNA transfer is a mechanism for cell–cell communication that is important in the immune response, in the functioning of the nervous system and in…”
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HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase by Goldstone, David C., Ennis-Adeniran, Valerie, Hedden, Joseph J., Groom, Harriet C. T., Rice, Gillian I., Christodoulou, Evangelos, Walker, Philip A., Kelly, Geoff, Haire, Lesley F., Yap, Melvyn W., de Carvalho, Luiz Pedro S., Stoye, Jonathan P., Crow, Yanick J., Taylor, Ian A., Webb, Michelle

“…Antiretroviral role for SAMHD1 protein Mutations in SAMHD1 protein are associated with the human autoimmune disease Aicardi–Goutières syndrome, and SAMHD1 was…”
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HIV-1 requires capsid remodelling at the nuclear pore for nuclear entry and integration by Guedán, Anabel, Donaldson, Callum D, Caroe, Eve R, Cosnefroy, Ophélie, Taylor, Ian A, Bishop, Kate N

“…The capsid (CA) lattice of the HIV-1 core plays a key role during infection. From the moment the core is released into the cytoplasm, it interacts with a range…”
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Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis by Morris, Elizabeth R., Caswell, Sarah J., Kunzelmann, Simone, Arnold, Laurence H., Purkiss, Andrew G., Kelly, Geoff, Taylor, Ian A.

“…SAMHD1 regulates cellular 2′-deoxynucleoside-5′-triphosphate (dNTP) homeostasis by catalysing the hydrolysis of dNTPs into 2′-deoxynucleosides and…”
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Diagnostic accuracy and clinical impact of renal biopsy cytology by Xu, Hongzhi, Taylor‐Cho, Ian A., “Sara” Jiang, Xiaoyin, Foo, Wen‐Chi

“…Background The role of fine needle biopsy cytology in the workup of renal mass lesions remains controversial. With advances in imaging technology and clinical…”
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Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1 by Rzechorzek, Neil J., Kunzelmann, Simone, Purkiss, Andrew G., Silva Dos Santos, Mariana, MacRae, James I., Taylor, Ian A., Fugger, Kasper, West, Stephen C.

“…Poly(ADP-ribose) polymerase (PARP) inhibitors are used in the clinic to treat BRCA -deficient breast, ovarian and prostate cancers. As their efficacy is…”
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A positive‐charged patch and stabilized hydrophobic core are essential for avirulence function of AvrPib in the rice blast fungus by Zhang, Xin, He, Dan, Zhao, Yanxiang, Cheng, Xilan, Zhao, Wensheng, Taylor, Ian A., Yang, Jun, Liu, Junfeng, Peng, You‐Liang

“…Summary Fungal avirulence effectors, a key weapon utilized by pathogens to promote their infection, are recognized by immune receptors to boost host R…”
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Structural basis of lentiviral subversion of a cellular protein degradation pathway by Schwefel, David, Groom, Harriet C. T., Boucherit, Virginie C., Christodoulou, Evangelos, Walker, Philip A., Stoye, Jonathan P., Bishop, Kate N., Taylor, Ian A.

“…The crystal structure of a ternary complex of the lentiviral accessory protein Vpx with the E3 ligase substrate adaptor DCAF1 and the HIV-1 restriction factor…”
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Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis by Acton, Oliver J., Sheppard, Devon, Kunzelmann, Simone, Caswell, Sarah J., Nans, Andrea, Burgess, Ailidh J. O., Kelly, Geoff, Morris, Elizabeth R., Rosenthal, Peter B., Taylor, Ian A.

“…SAMHD1 regulates cellular nucleotide homeostasis, controlling dNTP levels by catalysing their hydrolysis into 2’-deoxynucleosides and triphosphate. In…”
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Structural studies of postentry restriction factors reveal antiparallel dimers that enable avid binding to the HIV-1 capsid lattice by Goldstone, David C., Walker, Philip A., Calder, Lesley J., Coombs, Peter J., Kirkpatrick, Joshua, Ball, Neil J., Hilditch, Laura, Yap, Melvyn W., Rosenthal, Peter B., Stoye, Jonathan P., Taylor, Ian A.

“…Restriction factors (RFs) form important components of host defenses to retroviral infection. The Fv1, Trim5α, and TrimCyp RFs contain N-terminal dimerization…”
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Structural insights into Cullin4-RING ubiquitin ligase remodelling by Vpr from simian immunodeficiency viruses by Banchenko, Sofia, Krupp, Ferdinand, Gotthold, Christine, Bürger, Jörg, Graziadei, Andrea, O'Reilly, Francis J, Sinn, Ludwig, Ruda, Olga, Rappsilber, Juri, Spahn, Christian M T, Mielke, Thorsten, Taylor, Ian A, Schwefel, David

“…Viruses have evolved means to manipulate the host's ubiquitin-proteasome system, in order to down-regulate antiviral host factors. The Vpx/Vpr family of…”
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Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction by Arnold, Laurence H, Groom, Harriet C T, Kunzelmann, Simone, Schwefel, David, Caswell, Sarah J, Ordonez, Paula, Mann, Melanie C, Rueschenbaum, Sabrina, Goldstone, David C, Pennell, Simon, Howell, Steven A, Stoye, Jonathan P, Webb, Michelle, Taylor, Ian A, Bishop, Kate N

“…SAMHD1 restricts HIV-1 infection of myeloid-lineage and resting CD4+ T-cells. Most likely this occurs through deoxynucleoside triphosphate triphosphohydrolase…”
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Structural basis for Fullerene geometry in a human endogenous retrovirus capsid by Acton, Oliver, Grant, Tim, Nicastro, Giuseppe, Ball, Neil J., Goldstone, David C., Robertson, Laura E., Sader, Kasim, Nans, Andrea, Ramos, Andres, Stoye, Jonathan P., Taylor, Ian A., Rosenthal, Peter B.

“…The HML2 (HERV-K) group constitutes the most recently acquired family of human endogenous retroviruses, with many proviruses less than one million years old…”
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Structure of a Ty1 restriction factor reveals the molecular basis of transposition copy number control by Cottee, Matthew A., Beckwith, Sean L., Letham, Suzanne C., Kim, Sarah J., Young, George R., Stoye, Jonathan P., Garfinkel, David J., Taylor, Ian A.

“…Excessive replication of Saccharomyces cerevisiae Ty1 retrotransposons is regulated by Copy Number Control, a process requiring the p22/p18 protein produced…”
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A new class of capsid-targeting inhibitors that specifically block HIV-1 nuclear import by Boulay, Aude, Quevarec, Emmanuel, Malet, Isabelle, Nicastro, Giuseppe, Chamontin, Célia, Perrin, Suzon, Henriquet, Corinne, Pugnière, Martine, Courgnaud, Valérie, Blaise, Mickaël, Marcelin, Anne-Geneviève, Taylor, Ian A, Chaloin, Laurent, Arhel, Nathalie J

“…HIV-1 capsids cross nuclear pore complexes (NPCs) by engaging with the nuclear import machinery. To identify compounds that inhibit HIV-1 nuclear import, we…”
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Multivalent interactions essential for lentiviral integrase function by Ballandras-Colas, Allison, Chivukula, Vidya, Gruszka, Dominika T., Shan, Zelin, Singh, Parmit K., Pye, Valerie E., McLean, Rebecca K., Bedwell, Gregory J., Li, Wen, Nans, Andrea, Cook, Nicola J., Fadel, Hind J., Poeschla, Eric M., Griffiths, David J., Vargas, Javier, Taylor, Ian A., Lyumkis, Dmitry, Yardimci, Hasan, Engelman, Alan N., Cherepanov, Peter

“…A multimer of retroviral integrase (IN) synapses viral DNA ends within a stable intasome nucleoprotein complex for integration into a host cell genome…”
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Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models by CHANG, Yong S, ADNANE, Jalila, WILKIE, Dean, CARTER, Christopher A, TAYLOR, Ian C. A, LYNCH, Mark, WILHELM, Scott, TRAIL, Pamela A, LEVY, Joan, HENDERSON, Arris, DAHAI XUE, BORTOLON, Elizabeth, ICHETOVKIN, Marina, CHEN, Charles, MCNABOLA, Angela

“…New research findings have revealed a key role for vascular endothelial growth factor (VEGF) in the stimulation of angiogenesis in clear cell renal carcinoma…”
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Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells by Tsai, Ming-Han C, Caswell, Sarah J, Morris, Elizabeth R, Mann, Melanie C, Pennell, Simon, Kelly, Geoff, Groom, Harriet C T, Taylor, Ian A, Bishop, Kate N

“…SAMHD1 is a deoxynucleotide triphosphohydrolase that restricts replication of HIV-1 in differentiated leucocytes. HIV-1 is not restricted in cycling cells and…”
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