Search Results - "Taylor, I."

The High Cost of Diabetes Drugs: Disparate Impact on the Most Vulnerable Patients by Taylor, Simeon I

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Structure of the human multidrug transporter ABCG2 by Taylor, Nicholas M. I., Manolaridis, Ioannis, Jackson, Scott M., Kowal, Julia, Stahlberg, Henning, Locher, Kaspar P.

“…ABCG2 is a constitutively expressed ATP-binding cassette (ABC) transporter that protects many tissues against xenobiotic molecules. Its activity affects the…”
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Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states by Manolaridis, Ioannis, Jackson, Scott M., Taylor, Nicholas M. I., Kowal, Julia, Stahlberg, Henning, Locher, Kaspar P.

“…ABCG2 is a transporter protein of the ATP-binding-cassette (ABC) family that is expressed in the plasma membrane in cells of various tissues and tissue…”
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How quantitative is metabarcoding: A meta‐analytical approach by Lamb, Philip D., Hunter, Ewan, Pinnegar, John K., Creer, Simon, Davies, Richard G., Taylor, Martin I.

“…Metabarcoding has been used in a range of ecological applications such as taxonomic assignment, dietary analysis and the analysis of environmental DNA…”
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Structure of the T4 baseplate and its function in triggering sheath contraction by Taylor, Nicholas M. I., Prokhorov, Nikolai S., Guerrero-Ferreira, Ricardo C., Shneider, Mikhail M., Browning, Christopher, Goldie, Kenneth N., Stahlberg, Henning, Leiman, Petr G.

“…Several systems, including contractile tail bacteriophages, the type VI secretion system and R-type pyocins, use a multiprotein tubular apparatus to attach to…”
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Enhanced dopamine detection sensitivity by PEDOT/graphene oxide coating on in vivo carbon fiber electrodes by Taylor, I. Mitch, Robbins, Elaine M., Catt, Kasey A., Cody, Patrick A., Happe, Cassandra L., Cui, Xinyan Tracy

“…Dopamine (DA) is a monoamine neurotransmitter responsible for regulating a variety of vital life functions. In vivo detection of DA poses a challenge due to…”
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Information sharing to support care transitions for patients with complex mental health and social needs by Bucy, Taylor I., Cross, Dori A.

“…Background Patients with complex behavioral and mental health conditions require significant transitional care coordination. It is unclear how skilled nursing…”
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GLP-1 receptor agonists: differentiation within the class by Taylor, Simeon I

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Synthetic Genetic Polymers Capable of Heredity and Evolution by Pinheiro, Vitor B., Taylor, Alexander I., Cozens, Christopher, Abramov, Mikhail, Renders, Marleen, Zhang, Su, Chaput, John C., Wengel, Jesper, Peak-Chew, Sew-Yeu, McLaughlin, Stephen H., Herdewijn, Piet, Holliger, Philipp

“…Genetic information storage and processing rely on just two polymers, DNA and RNA, yet whether their role reflects evolutionary history or fundamental…”
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Structural basis of small-molecule inhibition of human multidrug transporter ABCG2 by Jackson, Scott M., Manolaridis, Ioannis, Kowal, Julia, Zechner, Melanie, Taylor, Nicholas M. I., Bause, Manuel, Bauer, Stefanie, Bartholomaeus, Ruben, Bernhardt, Guenther, Koenig, Burkhard, Buschauer, Armin, Stahlberg, Henning, Altmann, Karl-Heinz, Locher, Kaspar P.

“…ABCG2 is an ATP-binding cassette (ABC) transporter that protects tissues against xenobiotics, affects the pharmacokinetics of drugs and contributes to…”
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Evaluation of smartphone‐based testing to generate exploratory outcome measures in a phase 1 Parkinson's disease clinical trial by Lipsmeier, Florian, Taylor, Kirsten I., Kilchenmann, Timothy, Wolf, Detlef, Scotland, Alf, Schjodt‐Eriksen, Jens, Cheng, Wei‐Yi, Fernandez‐Garcia, Ignacio, Siebourg‐Polster, Juliane, Jin, Liping, Soto, Jay, Verselis, Lynne, Boess, Frank, Koller, Martin, Grundman, Michael, Monsch, Andreas U., Postuma, Ronald B., Ghosh, Anirvan, Kremer, Thomas, Czech, Christian, Gossens, Christian, Lindemann, Michael

“…ABSTRACT Background: Ubiquitous digital technologies such as smartphone sensors promise to fundamentally change biomedical research and treatment monitoring in…”
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SGLT2 inhibitors as adjunctive therapy for type 1 diabetes: balancing benefits and risks by Taylor, Simeon I, Blau, Jenny E, Rother, Kristina I, Beitelshees, Amber L

“…Sodium-glucose co-transporter-2 (SGLT2) inhibitors have several beneficial effects in patients with type 2 diabetes, including glucose lowering, weight loss,…”
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Targeting HER2 aberrations as actionable drivers in lung cancers: phase II trial of the pan-HER tyrosine kinase inhibitor dacomitinib in patients with HER2-mutant or amplified tumors by Kris, M.G., Camidge, D.R., Giaccone, G., Hida, T., Li, B.T., O'Connell, J., Taylor, I., Zhang, H., Arcila, M.E., Goldberg, Z., Jänne, P.A.

“…HER2 mutations and amplifications have been identified as oncogenic drivers in lung cancers. Dacomitinib, an irreversible inhibitor of HER2, EGFR (HER1), and…”
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Access to preferred skilled nursing facilities: Transitional care pathways for patients with Alzheimer's disease and related dementias by Cross, Dori A., Bucy, Taylor I., Rahman, Momotazur, McHugh, John P.

“…Objective The study aimed to assess whether individuals with Alzheimer's disease and related dementias (ADRD) experience restricted access to hospitals'…”
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Application of SNPs for population genetics of nonmodel organisms: new opportunities and challenges by HELYAR, S. J., HEMMER-HANSEN, J., BEKKEVOLD, D., TAYLOR, M. I., OGDEN, R., LIMBORG, M. T., CARIANI, A., MAES, G. E., DIOPERE, E., CARVALHO, G. R., NIELSEN, E. E.

“…Recent improvements in the speed, cost and accuracy of next generation sequencing are revolutionizing the discovery of single nucleotide polymorphisms (SNPs)…”
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Genome duplication in amphibians and fish: an extended synthesis by Mable, B. K., Alexandrou, M. A., Taylor, M. I.

“…Whole genome duplication (leading to polyploidy) is widely accepted as an important evolutionary force in plants, but it is less recognized as a driver of…”
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XNAzymes targeting the SARS-CoV-2 genome inhibit viral infection by Gerber, Pehuén Pereyra, Donde, Maria J., Matheson, Nicholas J., Taylor, Alexander I.

“…The unprecedented emergence and spread of SARS-CoV-2, the coronavirus responsible for the COVID-19 pandemic, underscores the need for diagnostic and…”
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Development and efficacy of Streptococcus iniae live-attenuated vaccines in Nile tilapia, Oreochromis niloticus by Heckman, Taylor I., Shahin, Khalid, Henderson, Eileen E., Griffin, Matt J., Soto, Esteban

“…Streptococcus iniae is a re-emerging bacterial pathogen in freshwater and marine aquaculture worldwide. There are no commercial vaccines available for S. iniae…”
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General Principles Underpinning Amyloid Structure by Taylor, Alexander I. P., Staniforth, Rosemary A.

“…Amyloid fibrils are a pathologically and functionally relevant state of protein folding, which is generally accessible to polypeptide chains and differs…”
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Electrochemical detection of exogenously administered melatonin in the brain by Castagnola, Elisa, Woeppel, Kevin, Golabchi, Asiyeh, McGuier, Moriah, Chodapaneedi, Neharika, Metro, Julian, Taylor, I Mitch, Cui, X Tracy

“…Melatonin (MT) is an important electroactive hormone that regulates different physiological actions in the brain, ranging from circadian clock to…”
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