Search Results - "Taylor, Ewan R"

Cleavage mechanism of human Mus81-Eme1 acting on Holliday-junction structures by Taylor, Ewan R, McGowan, Clare H

“…Recombination-mediated repair plays a central role in maintaining genomic integrity during DNA replication. The human Mus81-Eme1 endonuclease is involved in…”
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CtIP is required to initiate replication-dependent interstrand crosslink repair by Duquette, Michelle L, Zhu, Qingyuan, Taylor, Ewan R, Tsay, Angela J, Shi, Linda Z, Berns, Michael W, McGowan, Clare H

“…DNA interstrand crosslinks (ICLs) are toxic lesions that block the progression of replication and transcription. CtIP is a conserved DNA repair protein that…”
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Current Therapeutic Landscape and Safety Roadmap for Targeting the Aryl Hydrocarbon Receptor in Inflammatory Gastrointestinal Indications by Faber, Samantha C, Lahoti, Tejas S, Taylor, Ewan R, Lewis, Lauren, Sapiro, Jessica M, Toledo Sales, Vicencia, Dragan, Yvonne P, Jeffy, Brandon D

“…Target modulation of the AhR for inflammatory gastrointestinal (GI) conditions holds great promise but also the potential for safety liabilities both within…”
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P53 represses human papillomavirus type 16 DNA replication via the viral E2 protein by Brown, Craig, Kowalczyk, Anna M, Taylor, Ewan R, Morgan, Iain M, Gaston, Kevin

“…Human papillomavirus (HPV) DNA replication can be inhibited by the cellular tumour suppressor protein p53. However, the mechanism through which p53 inhibits…”
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A Functional Interaction between the Human Papillomavirus 16 Transcription/Replication Factor E2 and the DNA Damage Response Protein TopBP1 by Boner, Winifred, Taylor, Ewan R., Tsirimonaki, Emmanouella, Yamane, Kazuhiko, Campo, M. Saveria, Morgan, Iain M.

“…The human papillomavirus (HPV) transcription/replication factor E2 is essential for the life cycle of HPVs. E2 protein binds to DNA target sequences in the…”
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Fragment-Based Discovery of a Small Molecule Inhibitor of Bruton’s Tyrosine Kinase by Smith, Christopher R., Dougan, Douglas R., Komandla, Mallareddy, Kanouni, Toufike, Knight, Beverly, Lawson, J. David, Sabat, Mark, Taylor, Ewan R., Vu, Phong, Wyrick, Corey

“…The discovery and optimization of a series of 4-aminocinnoline-3-carboxamide inhibitors of Bruton’s tyrosine kinase are reported. A fragment-based screening…”
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Discovery of the Bruton’s Tyrosine Kinase Inhibitor Clinical Candidate TAK-020 (S)‑5-(1-((1-Acryloylpyrrolidin-3-yl)oxy)isoquinolin-3-yl)-2,4-dihydro‑3H‑1,2,4-triazol-3-one, by Fragment-Based Drug Design by Sabat, Mark, Dougan, Douglas R, Knight, Beverly, Lawson, J. David, Scorah, Nicholas, Smith, Christopher R, Taylor, Ewan R, Vu, Phong, Wyrick, Corey, Wang, Haixia, Balakrishna, Deepika, Hixon, Mark, Madakamutil, Loui, McConn, Donavon

“…This publication details the successful use of FBDD (fragment-based drug discovery) principles in the invention of a novel covalent Bruton’s tyrosine kinase…”
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Human SLX4 Is a Holliday Junction Resolvase Subunit that Binds Multiple DNA Repair/Recombination Endonucleases by Fekairi, Samira, Scaglione, Sarah, Chahwan, Charly, Taylor, Ewan R., Tissier, Agnès, Coulon, Stéphane, Dong, Meng-Qiu, Ruse, Cristian, Yates, John R., Russell, Paul, Fuchs, Robert P., McGowan, Clare H., Gaillard, Pierre-Henri L.

“…Structure-specific endonucleases resolve DNA secondary structures generated during DNA repair and recombination. The yeast 5′ flap endonuclease Slx1-Slx4 has…”
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Discovery of the Bruton's Tyrosine Kinase Inhibitor Clinical Candidate TAK-020 ( S )-5-(1-((1-Acryloylpyrrolidin-3-yl)oxy)isoquinolin-3-yl)-2,4-dihydro-3 H -1,2,4-triazol-3-one, by Fragment-Based Drug Design by Sabat, Mark, Dougan, Douglas R, Knight, Beverly, Lawson, J David, Scorah, Nicholas, Smith, Christopher R, Taylor, Ewan R, Vu, Phong, Wyrick, Corey, Wang, Haixia, Balakrishna, Deepika, Hixon, Mark, Madakamutil, Loui, McConn, Donavon

“…This publication details the successful use of FBDD (fragment-based drug discovery) principles in the invention of a novel covalent Bruton's tyrosine kinase…”
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The Fidelity of HPV16 E1/E2-mediated DNA Replication by Taylor, Ewan R., Dornan, Edward S., Boner, Winifred, Connolly, Julie A., McNair, Shona, Kannouche, Patricia, Lehmann, A.R., Morgan, Iain M.

“…Human papillomaviruses (HPV) are causative agents in a variety of human diseases; for example over 99% of cervical carcinomas contain HPV DNA sequences. Often…”
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A novel technique with enhanced detection and quantitation of HPV-16 E1- and E2-mediated DNA replication by Taylor, Ewan R, Morgan, Iain M

“…Transient DNA replication assays to detect papillomavirus E1/E2-mediated DNA replication have depended upon Southern blotting. This technique is hazardous…”
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Detection and quantitation of HPV DNA replication by Southern blotting and real-time PCR by Morgan, Iain M, Taylor, Ewan R

“…This provides a brief introduction into the mechanism of DNA replication by the E1 and E2 proteins and describes the traditional Southern blotting technique…”
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UVB irradiation reduces the half-life and transactivation potential of the human papillomavirus 16 E2 protein by TAYLOR, Ewan R, BONER, Winifred, DORNAN, Edward S, CORR, Eilidh M, MORGAN, Lain M

“…Human papillomaviruses (HPV) are causative agents of human cancers including those of the cervix and also of the head and neck; HPV16 is the most commonly…”
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Correction to “Discovery of the Bruton’s Tyrosine Kinase Inhibitor Clinical Candidate TAK-020 ( S )-5-(1-((1-Acryloylpyrrolidin-3-yl)oxy)isoquinolin-3-yl)-2,4-dihydro-3 H -1,2,4-triazol-3-one, by Fragment-Based Drug Design” by Sabat, Mark, Dougan, Douglas R, Ermolieff, Jacques, Halkowycz, Petro, Knight, Beverly, Lawson, J. David, Scorah, Nicholas, Smith, Christopher R, Taylor, Ewan R, Vu, Phong, Wyrick, Corey, Wang, Haixia, Balakrishna, Deepika, Hixon, Mark, Madakamutil, Loui, McConn, Donavon

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Correction to “Discovery of the Bruton’s Tyrosine Kinase Inhibitor Clinical Candidate TAK-020 (S)‑5-(1-((1-Acryloylpyrrolidin-3-yl)oxy)isoquinolin-3-yl)-2,4-dihydro‑3H‑1,2,4-triazol-3-one, by Fragment-Based Drug Design” by Sabat, Mark, Dougan, Douglas R, Ermolieff, Jacques, Halkowycz, Petro, Knight, Beverly, Lawson, J. David, Scorah, Nicholas, Smith, Christopher R, Taylor, Ewan R, Vu, Phong, Wyrick, Corey, Wang, Haixia, Balakrishna, Deepika, Hixon, Mark, Madakamutil, Loui, McConn, Donavon

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Human SLX4 Is a Holliday Junction Resolvase Subunit that Binds Multiple DNA Repair/Recombination Endonucleases by Fekairi, Samira, Scaglione, Sarah, Chahwan, Charly, Taylor, Ewan R, Tissier, Agnes, Coulon, Stephane, Dong, Meng-Qiu, Ruse, Cristian, Yates, John R, Russell, Paul, Fuchs, Robert P, McGowan, Clare H, Gaillard, Pierre-Henri L

“…Structure-specific endonucleases resolve DNA secondary structures generated during DNA repair and recombination. The yeast 5' flap endonuclease Slx1-Slx4 has…”
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The role of dna damage proteins and signaling pathways in the regulatory functions of the human papillomavirus 16 e2 protein by Taylor, Ewan R

“…Human papillomavirus type 16 (HPVI6) is a causative agent of cervical cancer. The HPV16 viral transcription/replication factor E2 is essential for the viral…”
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The role of DNA damage proteins and signaling pathways in the regulatory functions of the human papillomavirus 16E2 protein by Taylor, Ewan R

“…Human papillomavirus type 16 (HPVI6) is a causative agent of cervical cancer. The HPV16 viral transcription/replication factor E2 is essential for the viral…”
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