Search Results - "Taylor, Elaine M."

Molecular basis for PrimPol recruitment to replication forks by RPA by Guilliam, Thomas A., Brissett, Nigel C., Ehlinger, Aaron, Keen, Benjamin A., Kolesar, Peter, Taylor, Elaine M., Bailey, Laura J., Lindsay, Howard D., Chazin, Walter J., Doherty, Aidan J.

“…DNA damage and secondary structures can stall the replication machinery. Cells possess numerous tolerance mechanisms to complete genome duplication in the…”
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DNA replication stress and cancer: cause or cure? by Taylor, Elaine M, Lindsay, Howard D

“…There is an extensive and growing body of evidence that DNA replication stress is a major driver in the development and progression of many cancers, and that…”
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Cip29 is phosphorylated following activation of the DNA damage response in Xenopus egg extracts by Holden, Janet, Taylor, Elaine M, Lindsay, Howard D

“…Acting through a complex signalling network, DNA lesions trigger a range of cellular responses including DNA repair, cell cycle arrest, altered gene expression…”
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Depletion of Uhrf1 inhibits chromosomal DNA replication in Xenopus egg extracts by Taylor, Elaine M, Bonsu, Nicola M, Price, R Jordan, Lindsay, Howard D

“…UHRF1 (ubiquitin-like, containing PHD and RING finger domains 1) has a well-established role in epigenetic regulation through the recognition of various…”
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Identification of the Proteins, Including MAGEG1, That Make Up the Human SMC5-6 Protein Complex by Taylor, Elaine M., Copsey, Alice C., Hudson, Jessica J. R., Vidot, Susanne, Lehmann, Alan R.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Mre11/Rad50/Nbs1 complex functions in resection-based DNA end joining in Xenopus laevis by Taylor, Elaine M, Cecillon, Sophie M, Bonis, Antonio, Chapman, J. Ross, Povirk, Lawrence F, Lindsay, Howard D

“…The repair of DNA double-strand breaks (DSBs) is essential to maintain genomic integrity. In higher eukaryotes, DNA DSBs are predominantly repaired by…”
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Xeroderma Pigmentosum and Trichothiodystrophy are Associated with Different Mutations in the XPD (ERCC2) Repair/Transcription Gene by Taylor, Elaine M., Broughton, Bernard C., Botta, Elena, Stefanini, Miria, Sarasin, Alain, Nicolaas G. J. Jaspers, Fawcett, Heather, Harcourt, Susan A., Arlett, Colin F., Lehmann, Alan R.

“…The xeroderma pigmentosum group D (XPD) protein has a dual function, both in nucleotide excision repair of DNA damage and in basal transcription. Mutations in…”
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Crucial role of the NSE1 RING domain in Smc5/6 stability and FANCM-independent fork progression by Lorite, Neus P, Apostolova, Sonia, Guasch-Vallés, Marta, Pryer, Aaron, Unzueta, Fernando, Freire, Raimundo, Solé-Soler, Roger, Pedraza, Neus, Dolcet, Xavier, Garí, Eloi, Agell, Neus, Taylor, Elaine M, Colomina, Neus, Torres-Rosell, Jordi

“…The Smc5/6 complex is a highly conserved molecular machine involved in the maintenance of genome integrity. While its functions largely depend on restraining…”
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Two individuals with features of both xeroderma pigmentosum and trichothiodystrophy highlight the complexity of the clinical outcomes of mutations in the XPD gene by BROUGHTON, Bernard C, BERNEBURG, Mark, SARASIN, Alain, BOHNERT, Elisabeth, KRUTMANN, Jean, DAVIDSON, Rosemarie, KRAEMER, Kenneth H, LEHMANN, Alan R, FAWCETT, Heather, TAYLOR, Elaine M, ARLETT, Colin F, NARDO, Tiziana, STEFANINI, Miria, MENEFEE, Emory, PRICE, Vera H, QUEILLE, Sophie

“…The xeroderma pigmentosum group D (XPD) protein is a subunit of transcription factor TFIIH with DNA helicase activity. TFIIH has two functions, in basal…”
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Characterization of a novel human SMC heterodimer homologous to the Schizosaccharomyces pombe Rad18/Spr18 complex by Taylor, E M, Moghraby, J S, Lees, J H, Smit, B, Moens, P B, Lehmann, A R

“…The structural maintenance of chromosomes (SMC) protein encoded by the fission yeast rad18 gene is involved in several DNA repair processes and has an…”
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The cancer-free phenotype in trichothiodystrophy is unrelated to its repair defect by BERNEBURG, M, CLINGEN, P. H, HARCOURT, S. A, LOWE, J. E, TAYLOR, E. M, GREEN, M. H. L, KRUTMANN, J, ARLETT, C. F, LEHMANN, A. R

“…The DNA repair-deficient genetic disorders xeroderma pigmentosum (XP) and trichothiodystrophy (TTD) can both result from mutations in the XPD gene, the sites…”
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The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes by Keegan, K S, Holtzman, D A, Plug, A W, Christenson, E R, Brainerd, E E, Flaggs, G, Bentley, N J, Taylor, E M, Meyn, M S, Moss, S B, Carr, A M, Ashley, T, Hoekstra, M F

“…A number of cell-cycle checkpoint genes have been shown to play important roles in meiosis. We have characterized the human and mouse counterpart of the…”
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1st MRC Human Genetics Symposium: Maintenance of Genomic Stability by Carr, Antony M, Taylor, Elaine M

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Microwave sterilization of hydrophilic contact lenses by Rohrer, M D, Terry, M A, Bulard, R A, Graves, D C, Taylor, E M

“…We used standard 2,450-MHz microwave irradiation to achieve sterilization of hydrophilic contact lenses contaminated with a variety of bacterial, fungal, and…”
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The genetics of the repair of 5-azacytidine-mediated DNA damage in the fission yeast Schizosaccharomyces pombe by Hegde, V, McFarlane, R J, Taylor, E M, Price, C

“…We have recently demonstrated that Schizosaccharomyces pombe cells treated with the nucleoside analogue 5-azacytidine (5-azaC) require previously characterised…”
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