Search Results - "Taya, Yoichi"

MOZ increases p53 acetylation and premature senescence through its complex formation with PML by Rokudai, Susumu, Laptenko, Oleg, Arnal, Suzzette M., Taya, Yoichi, Kitabayashi, Issay, Prives, Carol

“…Monocytic leukemia zinc finger (MOZ)/KAT6A is a MOZ, Ybf2/Sas3, Sas2, Tip60 (MYST)-type histone acetyltransferase that functions as a coactivator for acute…”
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Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway by Ziv, Yael, Shiloh, Yosef, Bielopolski, Dana, Galanty, Yaron, Lukas, Claudia, Taya, Yoichi, Schultz, David C, Lukas, Jiri, Bekker-Jensen, Simon, Bartek, Jiri

“…The cellular DNA-damage response is a signaling network that is vigorously activated by cytotoxic DNA lesions, such as double-strand breaks (DSBs). The DSB…”
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Novel p53 target gene FUCA1 encodes a fucosidase and regulates growth and survival of cancer cells by Ezawa, Issei, Sawai, Yuichiro, Kawase, Tatsuya, Okabe, Atsushi, Tsutsumi, Shuichi, Ichikawa, Hitoshi, Kobayashi, Yuka, Tashiro, Fumio, Namiki, Hideo, Kondo, Tadashi, Semba, Kentaro, Aburatani, Hiroyuki, Taya, Yoichi, Nakagama, Hitoshi, Ohki, Rieko

“…The tumor suppressor p53 functions by inducing the transcription of a collection of target genes. We previously attempted to identify p53 target genes by…”
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Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage by Inoue, Yasumichi, Kitagawa, Masatoshi, Taya, Yoichi

“…The retinoblastoma tumor suppressor protein (pRB) plays a critical role in the control of cell proliferation and in the DNA damage checkpoints. pRB inhibits…”
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PH Domain-Only Protein PHLDA3 Is a p53-Regulated Repressor of Akt by Kawase, Tatsuya, Ohki, Rieko, Shibata, Tatsuhiro, Tsutsumi, Shuichi, Kamimura, Naoko, Inazawa, Johji, Ohta, Tsutomu, Ichikawa, Hitoshi, Aburatani, Hiroyuki, Tashiro, Fumio, Taya, Yoichi

“…p53 and Akt are critical players regulating tumorigenesis with opposite effects: whereas p53 transactivates target genes to exert its function as a tumor…”
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TSPAN12 is a critical factor for cancer—fibroblast cell contact-mediated cancer invasion by Otomo, Ryo, Otsubo, Chihiro, Matsushima-Hibiya, Yuko, Miyazaki, Makoto, Tashiro, Fumio, Ichikawa, Hitoshi, Kohno, Takashi, Ochiya, Takahiro, Yokota, Jun, Nakagama, Hitoshi, Taya, Yoichi, Enari, Masato

“…Communication between cancer cells and their microenvironment controls cancer progression. Although the tumor suppressor p53 functions in a cell-autonomous…”
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PHLDA3 is a novel tumor suppressor of pancreatic neuroendocrine tumors by Ohki, Rieko, Saito, Kozue, Chen, Yu, Kawase, Tatsuya, Hiraoka, Nobuyoshi, Saigawa, Raira, Minegishi, Maiko, Aita, Yukie, Yanai, Goichi, Shimizu, Hiroko, Yachida, Shinichi, Sakata, Naoaki, Doi, Ryuichiro, Kosuge, Tomoo, Shimada, Kazuaki, Tycko, Benjamin, Tsukada, Toshihiko, Kanai, Yae, Sumi, Shoichiro, Namiki, Hideo, Taya, Yoichi, Shibata, Tatsuhiro, Nakagama, Hitoshi

“…The molecular mechanisms underlying the development of pancreatic neuroendocrine tumors (PanNETs) have not been well defined. We report here that the genomic…”
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Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase by Okamoto, Koji, Taya, Yoichi, Nakagama, Hitoshi

“…mdm2 and mdmx oncogenes play essential yet non-redundant roles in synergistic inactivation of the tumor suppressor, p53. While Mdm2 inhibits p53 activity…”
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IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis by Asano, Yoshinori, Kawase, Tatsuya, Okabe, Atsushi, Tsutsumi, Shuichi, Ichikawa, Hitoshi, Tatebe, Satoko, Kitabayashi, Issay, Tashiro, Fumio, Namiki, Hideo, Kondo, Tadashi, Semba, Kentaro, Aburatani, Hiroyuki, Taya, Yoichi, Nakagama, Hitoshi, Ohki, Rieko

“…The transcription factors HSF1 and p53 both modulate the stress response, thereby protecting and facilitating the recovery of stressed cells, but both have the…”
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Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability by Sears, R, Nuckolls, F, Haura, E, Taya, Y, Tamai, K, Nevins, J R

“…Our recent work has shown that activation of the Ras/Raf/ERK pathway extends the half-life of the Myc protein and thus enhances the accumulation of Myc…”
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Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2 by Abe, Yoshinori, Oda-Sato, Eri, Tobiume, Kei, Kawauchi, Keiko, Taya, Yoichi, Okamoto, Koji, Oren, Moshe, Tanaka, Nobuyuki

“…The hedgehog (Hh) signaling pathway regulates the development of many organs in mammals, and activation of this pathway is widely observed in human cancers…”
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Induction of ZEB Proteins by Inactivation of RB Protein Is Key Determinant of Mesenchymal Phenotype of Breast Cancer by Arima, Yoshimi, Hayashi, Hidemi, Sasaki, Mikako, Hosonaga, Mari, Goto, Takaaki M., Chiyoda, Tatsuyuki, Kuninaka, Shinji, Shibata, Tatsuhiro, Ohata, Hirokazu, Nakagama, Hitoshi, Taya, Yoichi, Saya, Hideyuki

“…We previously showed that depletion of the retinoblastoma protein (RB) induces down-regulation of the adhesion molecule E-cadherin and thereby triggers the…”
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Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis by GOTTLIEB, Tanya M, MARTINEZ LEAL, Juan Fernando, SEGER, Rony, TAYA, Yoichi, OREN, Moshe

“…The p53 tumor suppressor protein and the Akt/PKB kinase play important roles in the transduction of pro-apoptotic and anti-apoptotic signals, respectively. We…”
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p53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53 by Oda, Katsutoshi, Arakawa, Hirofumi, Tanaka, Tomoaki, Matsuda, Koichi, Tanikawa, Chizu, Mori, Toshiki, Nishimori, Hiroyuki, Tamai, Katsuyuki, Tokino, Takashi, Nakamura, Yusuke, Taya, Yoichi

“…Through direct cloning of p53 binding sequences from human genomic DNA, we have isolated a novel gene, designated p53AIP1 (p53-regulated Apoptosis-Inducing…”
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Monocytic Leukemia Zinc Finger (MOZ) Interacts with p53 to Induce p21 Expression and Cell-cycle Arrest by Rokudai, Susumu, Aikawa, Yukiko, Tagata, Yusuke, Tsuchida, Nobuo, Taya, Yoichi, Kitabayashi, Issay

“…Upon DNA damage, p53 can induce either cell-cycle arrest or apoptosis. Here we show that monocytic leukemia zinc finger (MOZ) forms a complex with p53 to…”
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Stress Signals Utilize Multiple Pathways To Stabilize p53 by Ashcroft, Margaret, Taya, Yoichi, Vousden, Karen H.

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The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites by Shieh, S Y, Ahn, J, Tamai, K, Taya, Y, Prives, C

“…Upon DNA damage, the amino terminus of p53 is phosphorylated at a number of serine residues including S20, a site that is particularly important in regulating…”
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NuMA Is Required for the Selective Induction of p53 Target Genes by Ohata, Hirokazu, Miyazaki, Makoto, Otomo, Ryo, Matsushima-Hibiya, Yuko, Otsubo, Chihiro, Nagase, Takahiro, Arakawa, Hirofumi, Yokota, Jun, Nakagama, Hitoshi, Taya, Yoichi, Enari, Masato

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Requirement of ATM for Rapid p53 Phosphorylation at Ser46 without Ser/Thr-Gln Sequences by Kodama, Masami, Otsubo, Chihiro, Hirota, Toru, Yokota, Jun, Enari, Masato, Taya, Yoichi

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Distinct and site-specific phosphorylation of the retinoblastoma protein at serine 612 in differentiated cells by Hattori, Takayuki, Uchida, Chiharu, Takahashi, Hirotaka, Yamamoto, Naoki, Naito, Mikihiko, Taya, Yoichi

“…The retinoblastoma susceptibility protein (pRB) is a phosphoprotein that regulates cell cycle progression at the G1/S transition. In quiescent and early G1…”
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