Search Results - "Tay, Savaş"

Microfluidic cell culture by Mehling, Matthias, Tay, Savaş

“…Graphical abstract…”
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Single-Cell Proteomics by Vistain, Luke F., Tay, Savaş

“…The inability to make broad, minimally biased measurements of a cell’s proteome stands as a major bottleneck for understanding how gene expression translates…”
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HSV-1 single-cell analysis reveals the activation of anti-viral and developmental programs in distinct sub-populations by Drayman, Nir, Patel, Parthiv, Vistain, Luke, Tay, Savaş

“…Viral infection is usually studied at the population level by averaging over millions of cells. However, infection at the single-cell level is highly…”
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Noise Facilitates Transcriptional Control under Dynamic Inputs by Kellogg, Ryan A., Tay, Savaş

“…Cells must respond sensitively to time-varying inputs in complex signaling environments. To understand how signaling networks process dynamic inputs into gene…”
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Automated microfluidic platform for dynamic and combinatorial drug screening of tumor organoids by Schuster, Brooke, Junkin, Michael, Kashaf, Sara Saheb, Romero-Calvo, Isabel, Kirby, Kori, Matthews, Jonathan, Weber, Christopher R., Rzhetsky, Andrey, White, Kevin P., Tay, Savaş

“…Three-dimensional (3D) cell culture technologies, such as organoids, are physiologically relevant models for basic and clinical applications. Automated…”
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Droplet-based high-throughput cultivation for accurate screening of antibiotic resistant gut microbes by Watterson, William J, Tanyeri, Melikhan, Watson, Andrea R, Cham, Candace M, Shan, Yue, Chang, Eugene B, Eren, A Murat, Tay, Savaş

“…Traditional cultivation approaches in microbiology are labor-intensive, low-throughput, and yield biased sampling of environmental microbes due to ecological…”
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Single-Cell Analysis: The Differences That Kill by Tay, Savaş

“…Using single-cell RNA sequencing, Avraham et al. investigate how variability in macrophage response to infection is controlled by variability within the…”
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High-throughput RNA sequencing of paraformaldehyde-fixed single cells by Phan, Hoang Van, van Gent, Michiel, Drayman, Nir, Basu, Anindita, Gack, Michaela U., Tay, Savaş

“…Single-cell transcriptomic studies that require intracellular protein staining, rare cell sorting, or inactivation of infectious pathogens are severely…”
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Viable cell culture in PDMS-based microfluidic devices by Tanyeri, Melikhan, Tay, Savaş

“…Microfluidics has played a vital role in developing novel methods to investigate biological phenomena at the molecular and cellular level during the last two…”
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Automated co-culture system for spatiotemporal analysis of cell-to-cell communication by Frank, Tino, Tay, Savaş

“…We present a microfluidic co-culture system that generates localized and precisely formulated immune signals among a population of cells, enabling…”
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Flow-switching allows independently programmable, extremely stable, high-throughput diffusion-based gradients by Frank, Tino, Tay, Savaş

“…An automated microfluidic cell culture platform that creates and maintains independently programmable diffusion-based gradients is reported. Temporal…”
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Microfluidic single-cell analysis for systems immunology by Junkin, Michael, Tay, Savaş

“…The immune system constantly battles infection and tissue damage, but exaggerated immune responses lead to allergies, autoimmunity and cancer. Discrimination…”
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Digital Quantification of Proteins and mRNA in Single Mammalian Cells by Albayrak, Cem, Jordi, Christian A., Zechner, Christoph, Lin, Jing, Bichsel, Colette A., Khammash, Mustafa, Tay, Savaş

“…Absolute quantification of macromolecules in single cells is critical for understanding and modeling biological systems that feature cellular heterogeneity…”
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Proximity sequencing for the detection of mRNA, extracellular proteins and extracellular protein complexes in single cells by Vistain, Luke, Keisham, Bijentimala, Xia, Junjie, Phan, Hoang Van, Tay, Savaş

“…Complex cellular functions occur via the coordinated formation and dissociation of protein complexes. Functions such as the response to a signaling ligand can…”
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Ultrasensitive digital quantification of cytokines and bacteria predicts septic shock outcomes by Abasıyanık, M. Fatih, Wolfe, Krysta, Van Phan, Hoang, Lin, Jing, Laxman, Bharathi, White, Steven R., Verhoef, Philip A., Mutlu, Gökhan M., Patel, Bhakti, Tay, Savaş

“…Quantification of pathogen and host biomarkers is essential for the diagnosis, monitoring, and treatment of infectious diseases. Here, we demonstrate sensitive…”
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High-Content Quantification of Single-Cell Immune Dynamics by Junkin, Michael, Kaestli, Alicia J., Cheng, Zhang, Jordi, Christian, Albayrak, Cem, Hoffmann, Alexander, Tay, Savaş

“…Cells receive time-varying signals from the environment and generate functional responses by secreting their own signaling molecules. Characterizing dynamic…”
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Processing stimulus dynamics by the NF-κB network in single cells by Son, Minjun, Wang, Andrew G., Keisham, Bijentimala, Tay, Savaş

“…Cells at the site of an infection experience numerous biochemical signals that vary in amplitude, space, and time. Despite the diversity of dynamic signals…”
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Automated Microfluidic System for Dynamic Stimulation and Tracking of Single Cells by Dettinger, Philip, Frank, Tino, Etzrodt, Martin, Ahmed, Nouraiz, Reimann, Andreas, Trenzinger, Christoph, Loeffler, Dirk, Kokkaliaris, Konstantinos D, Schroeder, Timm, Tay, Savaş

“…Dynamic environments determine cell fate decisions and function. Understanding the relationship between extrinsic signals on cellular responses and cell fate…”
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High-throughput microfluidic single-cell analysis pipeline for studies of signaling dynamics by Kellogg, Ryan A, Gómez-Sjöberg, Rafael, Leyrat, Anne A, Tay, Savaş

“…The authors of this protocol describe an approach that enables time-dependent analysis of dynamic processes in individual live cells for the quantitative…”
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High-throughput co-culture system for analysis of spatiotemporal cell-cell signaling by Son, Minjun, Wang, Andrew G., Kenna, Emma, Tay, Savaş

“…Study of spatial and temporal aspects of signaling between individual cells is essential in understanding development, the immune response, and host-pathogen…”
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