Search Results - "Taxman, Debra J."

The Mitochondrial Proteins NLRX1 and TUFM Form a Complex that Regulates Type I Interferon and Autophagy by Lei, Yu, Wen, Haitao, Yu, Yanbao, Taxman, Debra J., Zhang, Lu, Widman, Douglas G., Swanson, Karen V., Wen, Kwun-Wah, Damania, Blossom, Moore, Chris B., Giguère, Patrick M., Siderovski, David P., Hiscott, John, Razani, Babak, Semenkovich, Clay F., Chen, Xian, Ting, Jenny P.-Y.

“…The mitochondrial protein MAVS (also known as IPS-1, VISA, and CARDIF) interacts with RIG-I-like receptors (RLRs) to induce type I interferon (IFN-I). NLRX1 is…”
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The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA by Allen, Irving C., Scull, Margaret A., Moore, Chris B., Holl, Eda K., McElvania-TeKippe, Erin, Taxman, Debra J., Guthrie, Elizabeth H., Pickles, Raymond J., Ting, Jenny P.-Y.

“…The nucleotide-binding domain and leucine-rich-repeat-containing (NLR) family of pattern-recognition molecules mediate host immunity to various pathogenic…”
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Staphylococcus aureus Panton-Valentine leukocidin induces an inflammatory response in human phagocytes via the NLRP3 inflammasome by Holzinger, Dirk, Gieldon, Laura, Mysore, Vijayashree, Nippe, Nadine, Taxman, Debra J., Duncan, Joseph A., Broglie, Peter M., Marketon, Kristina, Austermann, Judith, Vogl, Thomas, Foell, Dirk, Niemann, Silke, Peters, Georg, Roth, Johannes, Löffler, Bettina

“…Activation of the NLRP3‐inflammasome contributes to Staphylococcus aureus PVL‐associated diseases, such as necrotizing pneumonia. The Staphylococcus aureus…”
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NLRP3 (NALP3, Cryopyrin) Facilitates In Vivo Caspase-1 Activation, Necrosis, and HMGB1 Release via Inflammasome-Dependent and -Independent Pathways by Willingham, Stephen B, Allen, Irving C, Bergstralh, Daniel T, Brickey, Willie June, Huang, Max Tze-Han, Taxman, Debra J, Duncan, Joseph A, Ting, Jenny P.-Y

“…Bacterial infection elicits a range of beneficial as well as detrimental host inflammatory responses. Key among these responses are macrophage/monocyte…”
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Cutting edge: NLRC5-dependent activation of the inflammasome by Davis, Beckley K, Roberts, Reid A, Huang, Max T, Willingham, Stephen B, Conti, Brian J, Brickey, W June, Barker, Brianne R, Kwan, Mildred, Taxman, Debra J, Accavitti-Loper, Mary-Ann, Duncan, Joseph A, Ting, Jenny P-Y

“…The nucleotide-binding domain leucine-rich repeat-containing proteins, NLRs, are intracellular sensors of pathogen-associated molecular patterns and…”
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Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC by Willingham, Stephen B, Bergstralh, Daniel T, O'Connor, William, Morrison, Amy C, Taxman, Debra J, Duncan, Joseph A, Barnoy, Shoshana, Venkatesan, Malabi M, Flavell, Richard A, Deshmukh, Mohanish, Hoffman, Hal M, Ting, Jenny P-Y

“…Cryopyrin (CIAS1, NLRP3) and ASC are components of the inflammasome, a multiprotein complex required for caspase-1 activation and cytokine IL-1beta production…”
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Porphyromonas gingivalis Mediates Inflammasome Repression in Polymicrobial Cultures through a Novel Mechanism Involving Reduced Endocytosis by Taxman, Debra J., Swanson, Karen V., Broglie, Peter M., Wen, Haitao, Holley-Guthrie, Elizabeth, Huang, Max Tze-Han, Callaway, Justin B., Eitas, Tim K., Duncan, Joseph A., Ting, Jenny P.Y.

“…The interleukin (IL)-1β-processing inflammasome has recently been identified as a target for pathogenic evasion of the inflammatory response by a number of…”
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The NLR Adaptor ASC/PYCARD Regulates DUSP10, Mitogen-activated Protein Kinase (MAPK), and Chemokine Induction Independent of the Inflammasome by Taxman, Debra J., Holley-Guthrie, Elizabeth A., Huang, Max Tze-Han, Moore, Chris B., Bergstralh, Daniel T., Allen, Irving C., Lei, Yu, Gris, Denis, Ting, Jenny Pan-Yun

“…ASC/PYCARD is a common adaptor for a diverse set of inflammasomes that activate caspase-1, most prominently the NLR-based inflammasome. Mounting evidence…”
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Risk and Protective Factors in the COVID-19 Pandemic: A Rapid Evidence Map by Elmore, Rebecca, Schmidt, Lena, Lam, Juleen, Howard, Brian E, Tandon, Arpit, Norman, Christopher, Phillips, Jason, Shah, Mihir, Patel, Shyam, Albert, Tyler, Taxman, Debra J, Shah, Ruchir R

“…Given the worldwide spread of the 2019 Novel Coronavirus (COVID-19), there is an urgent need to identify risk and protective factors and expose areas of…”
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Deletion of ripA alleviates suppression of the inflammasome and MAPK by Francisella tularensis by Huang, Max Tze-Han, Mortensen, Brittany L, Taxman, Debra J, Craven, Robin R, Taft-Benz, Sharon, Kijek, Todd M, Fuller, James R, Davis, Beckley K, Allen, Irving Coy, Brickey, Willie June, Gris, Denis, Wen, Haitao, Kawula, Thomas H, Ting, Jenny Pan-Yun

“…Francisella tularensis is a facultative intracellular pathogen and potential biothreat agent. Evasion of the immune response contributes to the extraordinary…”
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Protein Phosphatase 2A Catalytic Subunit α Plays a MyD88-Dependent, Central Role in the Gene-Specific Regulation of Endotoxin Tolerance by Xie, Ling, Liu, Cui, Wang, Li, Gunawardena, Harsha P., Yu, Yanbao, Du, Ruyun, Taxman, Debra J., Dai, Penggao, Yan, Zhen, Yu, Jing, Holly, Stephen P., Parise, Leslie V., Wan, Yisong Y., Ting, Jenny P., Chen, Xian

“…MyD88, the intracellular adaptor of most TLRs, mediates either proinflammatory or immunosuppressive signaling that contributes to chronic…”
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Critical Role of Apoptotic Speck Protein Containing a Caspase Recruitment Domain (ASC) and NLRP3 in Causing Necrosis and ASC Speck Formation Induced by Porphyromonas gingivalis in Human Cells by Huang, Max Tze-Han, Taxman, Debra J, Holley-Guthrie, Elizabeth A, Moore, Chris B, Willingham, Stephen B, Madden, Victoria, Parsons, Rebecca Keyser, Featherstone, Gerald L, Arnold, Roland R, O'Connor, Brian P, Ting, Jenny Pan-Yun

“…Periodontal disease is a chronic inflammatory disorder that leads to the destruction of tooth-supporting tissue and affects 10-20 million people in the U.S…”
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Chromosomal Clustering of Genes Controlled by the Aire Transcription Factor by Johnnidis, Jonathan B., Venanzi, Emily S., Taxman, Debra J., Jenny P.-Y. Ting, Benoist, Christophe O., Mathis, Diane J.

“…Autoimmune regulator (aire) is a transcription factor that controls the self-reactivity of the T cell repertoire. Although previous results indicate that it…”
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Cutting Edge: ASC Mediates the Induction of Multiple Cytokines by Porphyromonas gingivalis via Caspase-1-Dependent and -Independent Pathways by Taxman, Debra J, Zhang, Jinghua, Champagne, Catherine, Bergstralh, Daniel T, Iocca, Heather A, Lich, John D, Ting, Jenny Pan-Yun

“…Porphyromonas gingivalis (Pg) is a major etiologic agent for chronic periodontitis. Tissue destruction by Pg results partly from induction of host inflammatory…”
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HIV-1 Infection Induces Interleukin-1β Production via TLR8 Protein-dependent and NLRP3 Inflammasome Mechanisms in Human Monocytes by Guo, Haitao, Gao, Jianmei, Taxman, Debra J., Ting, Jenny P.Y., Su, Lishan

“…The induction of inflammatory cytokines such as IL-1β is associated with the progression of human immunodeficiency virus, type 1 (HIV-1) disease or AIDS…”
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Short hairpin RNA (shRNA): design, delivery, and assessment of gene knockdown by Moore, Chris B, Guthrie, Elizabeth H, Huang, Max Tze-Han, Taxman, Debra J

“…Shortly after the cellular mechanism of RNA interference (RNAi) was first described, scientists began using this powerful technique to study gene function…”
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Selective Targeting of Leukemic Cell Growth in Vivo and in Vitro Using a Gene Silencing Approach to Diminish S-Adenosylmethionine Synthesis by Attia, Ramy R., Gardner, Lidia A., Mahrous, Engy, Taxman, Debra J., LeGros, Leighton, Rowe, Sarah, Ting, Jenny P.-Y., Geller, Arthur, Kotb, Malak

“…We exploited the fact that leukemic cells utilize significantly higher levels of S-adenosylmethionine (SAMe) than normal lymphocytes and developed tools that…”
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Cross-regulation between the IL-1β/IL-18 processing inflammasome and other inflammatory cytokines by Barker, Brianne R, Taxman, Debra J, Ting, Jenny P-Y

“…Highlights ► The IL-1β/IL-18-processing inflammasome is composed of an NLR sensor, Aim2 or RIG-I; the adaptor ASC/Pycard; and caspase-1. ► Many inflammasome…”
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Discovery of a Viral NLR Homolog that Inhibits the Inflammasome by Gregory, Sean M, Davis, Beckley K, West, John A, Taxman, Debra J, Matsuzawa, Shu-ichi, Reed, John C, Ting, Jenny P.Y, Damania, Blossom

“…The NLR (nucleotide binding and oligomerization, leucine-rich repeat) family of proteins senses microbial infections and activates the inflammasome, a…”
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Inactivation of the Antiapoptotic Phosphatidylinositol 3-Kinase-Akt Pathway by the Combined Treatment of Taxol and Mitogen-activated Protein Kinase Kinase Inhibition by MACKEIGAN, Jeffrey P, TAXMAN, Debra J, HUNTER, Deborah, EARP, H. Shelton, GRAVES, Lee M, TING, Jenny P-Y

“…Paclitaxel (Taxol) activates a number of signal transduction pathways that lead to apoptosis.In contrast, paclitaxel also activates cell survival pathways,…”
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