Search Results - "Tawfik, O"

The histone demethylase KDM4B regulates peritoneal seeding of ovarian cancer by Wilson, C, Qiu, L, Hong, Y, Karnik, T, Tadros, G, Mau, B, Ma, T, Mu, Y, New, J, Louie, R J, Gunewardena, S, Godwin, A K, Tawfik, O W, Chien, J, Roby, K F, Krieg, A J

“…Epithelial ovarian cancer (EOC) has poor prognosis and rapid recurrence because of widespread dissemination of peritoneal metastases at diagnosis. Multiple…”
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Dependence on linkers' flexibility designed for benzenesulfonamides targeting discovery of novel hCA IX inhibitors as potent anticancer agents by Tawfik, Haytham O., Belal, Amany, Abourehab, Mohammed A. S., Angeli, Andrea, Bonardi, Alessandro, Supuran, Claudiu T., El-Hamamsy, Mervat H.

“…Herein we reported the design and synthesis of two series comprising twenty-two benzenesulfonamides that integrate the s-triazine moiety. Target compounds…”
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Evaluating the ability of some natural phenolic acids to target the main protease and AAK1 in SARS COV-2 by Ghamry, Heba I., Belal, Amany, El-Ashrey, Mohamed Kandeel, Tawfik, Haytham O., Alsantali, Reem I., Obaidullah, Ahmad J., El-Mansi, Ahmed A., Abdelrahman, Doaa

“…Researchers are constantly searching for drugs to combat the coronavirus pandemic caused by SARS-CoV-2, which has lasted for over two years. Natural compounds…”
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Investigating the potential anticancer activities of antibiotics as topoisomerase II inhibitors and DNA intercalators: in vitro, molecular docking, molecular dynamics, and SAR studies by Farouk, Faten, Elmaaty, Ayman Abo, Elkamhawy, Ahmed, Tawfik, Haytham O., Alnajjar, Radwan, Abourehab, Mohammed A. S., Saleh, Mohamed A., Eldehna, Wagdy M., Al-Karmalawy, Ahmed A.

“…Topoisomerase II (TOP-2) is a promising molecular target for cancer therapy. Numerous antibiotics could interact with biologically relevant macromolecules and…”
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Novel 3-(6-methylpyridin-2-yl)coumarin-based chalcones as selective inhibitors of cancer-related carbonic anhydrases IX and XII endowed with anti-proliferative activity by Tawfik, Haytham O., Shaldam, Moataz A., Nocentini, Alessio, Salem, Rofaida, Almahli, Hadia, Al-Rashood, Sara T., Supuran, Claudiu T., Eldehna, Wagdy M.

“…Carbonic anhydrases (CAs) are one of the promising targets for the development of anticancer agents. CA isoforms are implicated in various physiological…”
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Machine Learning for Automated Calculation of Vestibular Schwannoma Volumes by Cass, Nathan D., Lindquist, Nathan R., Zhu, Qibang, Li, Hao, Oguz, Ipek, Tawfik, Kareem O.

“…Machine learning-derived algorithms are capable of automated calculation of vestibular schwannoma tumor volumes without operator input. Volumetric measurements…”
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Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors by Shaldam, Moataz A., Almahli, Hadia, Angeli, Andrea, Badi, Rehab Mustafa, Khaleel, Eman F., Zain-Alabdeen, Abdelrahman I., Elsayed, Zainab M., Elkaeed, Eslam B., Salem, Rofaida, Supuran, Claudiu T., Eldehna, Wagdy M., Tawfik, Haytham O.

“…In this work, new isatin-based sulphonamides (6a-i, 11a-c, 12a-c) were designed and synthesised as potential dual VEGFR-2 and carbonic anhydrase inhibitors…”
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Terminators or Guardians? Design, Synthesis, and Cytotoxicity Profiling of Chalcone-Sulfonamide Hybrids by Aboukhatwa, Shaimaa M, Sidhom, Peter A, Angeli, Andrea, Supuran, Claudiu T, Tawfik, Haytham O

“…With a "less is more" philosophy, a series of 15 chalcone-sulfonamide hybrids were designed anticipating synergistic anticancer activity. The aromatic…”
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Papaverinol- N -Oxide: A Microbial Biotransformation Product of Papaverine with Potential Antidiabetic and Antiobesity Activity Unveiled with In Silico Screening by Eliwa, Duaa, Kabbash, Amal, El-Aasr, Mona, Tawfik, Haytham O, Batiha, Gaber El-Saber, Mahmoud, Mohamed H, De Waard, Michel, Eldehna, Wagdy M, Ibrahim, Abdel-Rahim S

“…Bioconversion of biosynthetic heterocyclic compounds has been utilized to produce new semisynthetic pharmaceuticals and study the metabolites of bioactive…”
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A NOVEL TREATMENT BY GRAPHENE-BASED NANOMATERIALS AND 6-BENZYLAMINOPURINE TO IMPROVE FLOWERING AND CORM PRODUCTION OF GLADIOLUS GRANDIFLORUS ANDREWS ‘WHITE PROSPERITY’ by Tawfik, O., Ibrahim, O.

“…Graphene-based nanomaterials have great potential to improve cut flower production, including the production of high-quality corms of gladiolus locally to…”
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Recruitment of hexahydroquinoline as anticancer scaffold targeting inhibition of wild and mutants EGFR (EGFR WT , EGFR T790M , and EGFR L858R ) by Abo Al-Hamd, Mahmoud G, Tawfik, Haytham O, Abdullah, Omeima, Yamaguchi, Koki, Sugiura, Masaharu, Mehany, Ahmed B M, El-Hamamsy, Mervat H, El-Moselhy, Tarek F

“…Hexahydroquinoline (HHQ) scaffold was constructed and recruited for development of new series of anticancer agents. Thirty-two new compounds were synthesised…”
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New Genetic Bomb Trigger: Design, Synthesis, Molecular Dynamics Simulation, and Biological Evaluation of Novel BIBR1532-Related Analogs Targeting Telomerase against Non-Small Cell Lung Cancer by Tawfik, Haytham O, El-Hamaky, Anwar A, El-Bastawissy, Eman A, Shcherbakov, Kirill A, Veselovsky, Alexander V, Gladilina, Yulia A, Zhdanov, Dmitry D, El-Hamamsy, Mervat H

“…Telomeres serve a critical function in cell replication and proliferation at every stage of the cell cycle. Telomerase is a ribonucleoprotein, responsible for…”
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Utility of a bacterial infection model to study epithelial–mesenchymal transition, mesenchymal–epithelial transition or tumorigenesis by Chandrakesan, P, Roy, B, Jakkula, L U M R, Ahmed, I, Ramamoorthy, P, Tawfik, O, Papineni, R, Houchen, C, Anant, S, Umar, S

“…DCLK1 and Lgr5 have recently been identified as markers of quiescent and cycling stem cells in the small intestinal crypts, respectively…”
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Discovery of new symmetrical and asymmetrical nitrile-containing 1,4-dihydropyridine derivatives as dual kinases and P-glycoprotein inhibitors: synthesis, in vitro assays, and in silico studies by Saad, Mohamed H., El-Moselhy, Tarek F., S, El-Din, Nabaweya, Mehany, Ahmed B. M., Belal, Amany, Abourehab, Mohammed A. S., Tawfik, Haytham O., El-Hamamsy, Mervat H.

“…Two new series of symmetric (1a-h) and asymmetric (2a-l) 1,4-DHP derivatives were designed, synthesised, and evaluated as anticancer agents. In vitro…”
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Impact of Motor-Evoked Potential Monitoring on Facial Nerve Outcomes after Vestibular Schwannoma Resection by Tawfik, Kareem O., Walters, Zoe A., Kohlberg, Gavriel D., Lipschitz, Noga, Breen, Joseph T., O’Neal, Kelly, Zuccarello, Mario, Samy, Ravi N.

“…Objectives: Assess the utility of intraoperative transcranial facial motor-evoked potential (FMEP) monitoring in predicting and improving facial function after…”
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PKCλ/ι signaling promotes triple-negative breast cancer growth and metastasis by Paul, A, Gunewardena, S, Stecklein, S R, Saha, B, Parelkar, N, Danley, M, Rajendran, G, Home, P, Ray, S, Jokar, I, Vielhauer, G A, Jensen, R A, Tawfik, O, Paul, S

“…Triple-negative breast cancer (TNBC) is a distinct breast cancer subtype defined by the absence of estrogen receptor (ER), progesterone receptor (PR) and…”
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Evaluation of Zamia floridana A. DC. Leaves and Its Isolated Secondary Metabolites as Natural Anti-Toxoplasma and Anti-Cancer Agents Using In Vitro and In Silico Studies by El-Seadawy, Hosam M, Abo El-Seoud, Kamilia A, El-Aasr, Mona, Tawfik, Haytham O, Eldehna, Wagdy M, Ragab, Amany E

“…Toxoplasmosis and cancer are life-threatening diseases with worldwide distribution. However, currently used chemosynthetic treatments are not devoid of their…”
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Toxoplasmocidal and Cytotoxic Activities Guided Isolation and Characterization of an Undescribed Bioflavonoid-di-C-glucoside from Cycas rumphii Miq. Cultivated in Egypt by El-Seadawy, Hosam M., Abo El-Seoud, Kamilia A., El-Aasr, Mona, Tawfik, Haytham O., Ragab, Amany E.

“…Toxoplasmosis and cancer are serious worldwide diseases, and the available drugs cause serious side effects. Investigation for new alternative therapies from…”
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CCN5/WISP-2 restores ER-∝ in normal and neoplastic breast cells and sensitizes triple negative breast cancer cells to tamoxifen by Sarkar, S, Ghosh, A, Banerjee, S, Maity, G, Das, A, Larson, M A, Gupta, V, Haque, I, Tawfik, O, Banerjee, S K

“…CCN5/WISP-2 is an anti-invasive molecule and prevents breast cancer (BC) progression. However, it is not well understood how CCN5 prevents invasive phenotypes…”
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Phosphoinositide 3-OH kinase p85α and p110β are essential for androgen receptor transactivation and tumor progression in prostate cancers by Zhu, Q, Youn, H, Tang, J, Tawfik, O, Dennis, K, Terranova, P F, Du, J, Raynal, P, Thrasher, J B, Li, B

“…Phosphoinositide 3-OH kinases (PI3Ks) are a group of major intracellular signaling molecules. In our previous study, we found that inhibition of PI3K activity…”
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