Search Results - "Tawe, Leabaneng"

High-risk human papillomavirus diversity among indigenous women of western Botswana with normal cervical cytology and dysplasia by Rantshabeng, Patricia S, Tsima, Billy M, Ndlovu, Andrew K, Motlhatlhedi, Keneilwe, Sharma, Kirthana, Masole, Carol B, Moraka, Natasha O, Motsumi, Kesego, Maoto-Mokote, Angela K T, Eshetu, Alemayehu B, Tawe, Leabaneng, Gaolathe, Tendani, Moyo, Sikhulile, Kyokunda, Lynnette T

“…Cervical cancer remains a public health problem despite heavy global investment in health systems especially in low-and-middle-income countries (LMIC)…”
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Genetic diversity in L1 ORF of human papillomavirus in women with cervical cancer with and without human immunodeficiency virus in Botswana and Kenya by Tawe, Leabaneng, Choga, Wonderful T, Paganotti, Giacomo M, Bareng, Ontlametse T, Ntereke, Tlhalefo D, Ramatlho, Pleasure, Ditshwanelo, Doreen, Gaseitsiwe, Simani, Kasvosve, Ishmael, Ramogola-Masire, Doreen, Orang'o, Omenge E, Robertson, Erle, Zetola, Nicola, Moyo, Sikhulile, Grover, Surbhi, Ermel, Aaron C

“…The variation of human papillomavirus (HPV) genotypes shapes the risks of cervical cancer and these variations are not well defined in Africa. Nucleotide…”
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Promoter Hypermethylation Analysis of Host Genes in Cervical Cancer Patients With and Without Human Immunodeficiency Virus in Botswana by Tawe, Leabaneng, Grover, Surbhi, Zetola, Nicola, Robertson, Erle S, Gaseitsiwe, Simani, Moyo, Sikhulile, Kasvosve, Ishmael, Paganotti, Giacomo M, Narasimhamurthy, Mohan

“…Epidemics of human immunodeficiency virus (HIV) and cervical cancer are interconnected. DNA hypermethylation of host genes' promoter in cervical lesions has…”
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Human cytochrome P450 2B6 genetic variability in Botswana: a case of haplotype diversity and convergent phenotypes by Tawe, Leabaneng, Motshoge, Thato, Ramatlho, Pleasure, Mutukwa, Naledi, Muthoga, Charles Waithaka, Dongho, Ghyslaine Bruna Djeunang, Martinelli, Axel, Peloewetse, Elias, Russo, Gianluca, Quaye, Isaac Kweku, Paganotti, Giacomo Maria

“…Identification of inter-individual variability for drug metabolism through cytochrome P450 2B6 (CYP2B6) enzyme is important for understanding the differences…”
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Molecular Surveillance of Plasmodium falciparum Drug Resistance Markers in Clinical Samples from Botswana by Tawe, Leabaneng, Menegon, Michela, Ramatlho, Pleasure, Muthoga, Charles W, Mutukwa, Naledi, Vurayai, Moses, Bothudile, Wame, Motshoge, Thato, L'Episcopia, Mariangela, Mosweunyane, Tjantilili, Kasvosve, Ishmael, Severini, Carlo, Paganotti, Giacomo M

“…Drug-resistant is a major threat to global malaria control and elimination efforts. In Botswana, a southern African country approaching malaria elimination,…”
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Cervical cancer screening in HIV-endemic countries: An urgent call for guideline change by Grover, Surbhi, Bhatia, Rohini, Friebel-Klingner, Tara M., Mathoma, Anikie, Vuylsteke, Peter, Khan, Salman, Ralefala, Tlotlo, Tawe, Leabaneng, Bazzett-Matabele, Lisa, Monare, Barati, Luckett, Rebecca, Ramogola-Masire, Doreen

“…•In Botswana, median age of cervical cancer diagnosis for women living with HIV was 47.9.•Among women living without HIV, median age at cervical cancer…”
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No Difference in the Prevalence of HIV-1 gag Cytotoxic T-Lymphocyte-Associated Escape Mutations in Viral Sequences from Early and Late Parts of the HIV-1 Subtype C Pandemic in Botswana by Mokaleng, Baitshepi, Choga, Wonderful Tatenda, Bareng, Ontlametse Thato, Maruapula, Dorcas, Ditshwanelo, Doreen, Kelentse, Nametso, Mokgethi, Patrick, Moraka, Natasha Onalenna, Motswaledi, Modisa Sekhamo, Tawe, Leabaneng, Koofhethile, Catherine Kegakilwe, Moyo, Sikhulile, Zachariah, Matshediso, Gaseitsiwe, Simani

“…HIV is known to accumulate escape mutations in the gene in response to the immune response from cytotoxic T lymphocytes (CTLs). These mutations can occur…”
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Comparison of the AmpFire® Multiplex HPV Assay to the Xpert® HPV Assay for detection of human papillomavirus and cervical disease in women with human immunodeficiency virus: a pragmatic performance evaluation by Moyo, Sikhulile, Ramogola-Masire, Doreen, Moraka, Natasha O, Tawe, Leabaneng, Noubary, Farzad, Motsumi, Kesego, Manowe, Godiraone, Zuze, Boitumelo, Radibe, Botshelo, Hungwe, Faith T T, Mohammed, Terence, Maphorisa, Comfort, Shapiro, Roger, Gaseitsiwe, Simani, Luckett, Rebecca

“…Low- and middle-income countries (LMICs) account for nearly 85% of the global cervical cancer burden, yet have the least access to high-performance screening…”
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Molecular detection of human papillomavirus (HPV) in highly fragmented DNA from cervical cancer biopsies using double-nested PCR by Tawe, Leabaneng, Grover, Surbhi, Narasimhamurthy, Mohan, Moyo, Sikhulile, Gaseitsiwe, Simani, Kasvosve, Ishmael, Paganotti, Giacomo M.

“…[Display omitted] Archived Formalin-Fixed Paraffin-Embedded (FFPE) tissue specimens can be a valuable source of human papillomavirus (HPV) nucleic acids for…”
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Cervical human papillomavirus genotypes in a high HIV setting: A scoping review of a decade of human papillomavirus epidemiological research in Botswana by Tawe, Leabaneng, Ramatlho, Pleasure, Ketlametswe, Rebecca, Koobotse, Moses, Robertson, Erle S, Grover, Surbhi, Ramogola-Masire, Doreen, Paganotti, Giacomo M

“…Cervical cancer burden is still high in low- and middle-income countries, including Botswana. Persistent human papillomavirus (HPV) infection is the leading…”
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Cytochrome P450 2C82 allele in Botswana: Human genetic diversity and public health implications by Motshoge, Thato, Tawe, Leabaneng, Muthoga, Charles Waithaka, Allotey, Joel, Romano, Rita, Quaye, Isaac, Paganotti, Giacomo Maria

“…We studied the frequency of CYP2C8*2 allele in two ethnic group from Botswana. In the San the rate of poor metabolisers of antimalarial drugs is higher than in…”
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Pharmacogenetics: uncovering the complex relationship between HIV and non-adherence among South African breast cancer patients treated with tamoxifen by Nthontho, Keneuoe C., Tawe, Leabaneng, Paganotti, Giacomo M.

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Past and current biological factors affecting malaria in the low transmission setting of Botswana: A review by Bango, Zackary Austin, Tawe, Leabaneng, Muthoga, Charles Waithaka, Paganotti, Giacomo Maria

“…Malaria continues to be one of the top infectious agents contributing to morbidity and mortality in sub-Saharan Africa. Annually, Botswana accounts only for a…”
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Human papillomavirus genotypes in women with invasive cervical cancer with and without human immunodeficiency virus infection in Botswana by Tawe, Leabaneng, MacDuffie, Emily, Narasimhamurthy, Mohan, Wang, Qiao, Gaseitsiwe, Simani, Moyo, Sikhulile, Kasvosve, Ishmael, Shin, Sanghyuk S., Zetola, Nicola M., Paganotti, Giacomo M., Grover, Surbhi

“…Cervical cancer remains a significant cause of morbidity and mortality in women worldwide and is the leading cause of cancer‐related death in Botswana. It is…”
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Evaluation of a Novel Semiquantitative Cryptococcal Antigen Lateral Flow Assay in Patients with Advanced HIV Disease by Jarvis, Joseph N, Tenforde, Mark W, Lechiile, Kwana, Milton, Thandi, Boose, Amber, Leeme, Tshepo B, Tawe, Leabaneng, Muthoga, Charles, Rukasha, Ivy, Mulenga, Fredah, Rulaganyang, Ikanyeng, Molefi, Mooketsi, Molloy, Síle F, Ngidi, Julia, Harrison, Thomas S, Govender, Nelesh P, Mine, Madisa

“…Higher cryptococcal antigen (CrAg) titers are strongly associated with mortality risk in individuals with HIV-associated cryptococcal disease. Rapid tests to…”
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The role of CYP2B6 516G>T polymorphism on efavirenz/nevirapine toxicity. Implications on treatment outcomes : Lessons from Botswana by Maseng, Monkgomotsi J., Tawe, Leabaneng, Thami, Prisca K., Moyo, Sikhulile, Kasvosve, Ishmael, Novitsky, Vladimir, Essex, Max, Russo, Gianluca, Gaseitsiwe, Simani, Paganotti, Giacomo M.

“…The two non-nucleoside reverse transcriptase inhibitors (NNRTIs), efavirenz (EFV) and nevirapine (NVP), are currently the core antiretroviral drugs for…”
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Triage of HPV positivity in a high HIV prevalence setting: A prospective cohort study comparing visual triage methods and HPV genotype restriction in Botswana by Luckett, Rebecca, Ramogola‐Masire, Doreen, Gompers, Annika, Moraka, Natasha, Moyo, Sikhulile, Sedabadi, Leatile, Tawe, Leabaneng, Kashamba, Thanolo, Gaborone, Kelebogile, Mathoma, Anikie, Noubary, Farzad, Kula, Maduke, Grover, Surbhi, Dreyer, Greta, Botha, Matthys H., Makhema, Joseph, Shapiro, Roger, Hacker, Michele R.

“…Objective Guidelines for effective triage following positive primary high‐risk human papillomavirus (HPV) screening in low‐ and middle‐income countries with…”
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The role of CYP2B6 516G>T polymorphism on efavirenz/nevirapine toxicity. Implications on treatment outcomes by Monkgomotsi J. Maseng, BSc, Leabaneng Tawe, PhD, Prisca K. Thami, PhD, Sikhulile Moyo, PhD, Ishmael Kasvosve, PhD, Vladimir Novitsky, PhD, Max Essex, PhD, Gianluca Russo, PhD, Simani Gaseitsiwe, PhD, Giacomo M. Paganotti, PhD, Jorddy Neves Cruz

“…The two non-nucleoside reverse transcriptase inhibitors (NNRTIs), efavirenz (EFV) and nevirapine (NVP), are currently the core antiretroviral drugs for…”
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Diagnostic Accuracy of the Biosynex CryptoPS Cryptococcal Antigen Semiquantitative Lateral Flow Assay in Patients with Advanced HIV Disease by Tenforde, Mark W, Boyer-Chammard, Timothée, Muthoga, Charles, Tawe, Leabaneng, Milton, Thandi, Rulaganyang, Ikanyeng, Lechiile, Kwana, Rukasha, Ivy, Leeme, Tshepo B, Govender, Nelesh P, Ngidi, Julia, Mine, Madisa, Molloy, Síle F, Harrison, Thomas S, Lortholary, Olivier, Jarvis, Joseph N

“…High cryptococcal antigen (CrAg) titers in blood are associated with subclinical meningitis and mortality in CrAg-positive individuals with advanced HIV…”
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Outcomes of Reflex Cryptococcal Antigen (CrAg) Screening in Human Immunodeficiency Virus (HIV)-Positive Patients With CD4 Counts of 100-200 Cells/µL in Botswana by Tenforde, Mark W, Milton, Thandi, Rulaganyang, Ikanyeng, Muthoga, Charles, Tawe, Leabaneng, Chiller, Tom, Greene, Gregory, Jordan, Alexander, Williams, Christopher G, Owen, Leah, Leeme, Tshepo B, Boose, Amber, Ngidi, Julia, Mine, Madisa, Jarvis, Joseph N

“…Increasing the CD4-count threshold for cryptococcal antigen (CrAg) screening from ≤100 to ≤200 cells/µL resulted in a 3-fold increase in numbers screened…”
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