Formulation, Optimization and Evaluation of Novel Ultra-deformable Vesicular Drug Delivery System for an Anti-fungal Drug
The present study is aimed at enhancing the skin penetration of ketoconazole by formulating it as transethosome. Ketoconazole-loaded transethosome formulations were prepared by conventional thin film evaporation and hydration method and were optimized using concentration of edge activator (span 80),...
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| Published in: | AAPS PharmSciTech Vol. 21; no. 5; p. 140 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Cham
Springer International Publishing
17-05-2020
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | The present study is aimed at enhancing the skin penetration of ketoconazole by formulating it as transethosome. Ketoconazole-loaded transethosome formulations were prepared by conventional thin film evaporation and hydration method and were optimized using concentration of edge activator (span 80), ethanol and sonication time as factors and particle size, polydispersity index and entrapment efficiency as responses. The optimized formulation was further evaluated for
in vitro
diffusion, anti-fungal activity,
ex vivo
penetration and
in vivo
pharmacodynamic activity. The results of
in vitro
drug diffusion and
ex vivo
skin penetration studies demonstrated that the amount of drug diffused and penetrated through the skin was increased. Optimized transethosomes showed enhanced
in vitro
antifungal and
in vivo
pharmacodynamic activities against
Candida albicans
in Wistar albino rats when compared to conventional liposomes. Therefore, the developed ketoconazole encapsulated transethosome formulation is capable of enhancing the skin penetration of the drug by overcoming the stratum corneum barrier function and acting as an effective drug delivery system for ketoconazole through the skin for its anti-fungal activity. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 1530-9932 1530-9932 |
| DOI: | 10.1208/s12249-020-01681-5 |