Search Results - "Tavori, Hagai"

Biology of proprotein convertase subtilisin kexin 9: beyond low-density lipoprotein cholesterol lowering by Norata, Giuseppe Danilo, Tavori, Hagai, Pirillo, Angela, Fazio, Sergio, Catapano, Alberico L

“…Proprotein convertase subtilisin kexin 9 (PCSK9) is a key regulator of low-density lipoprotein receptor levels and LDL-cholesterol levels. Loss-of-function…”
Get full text

Role of PAI-1 in hepatic steatosis and dyslipidemia by Levine, Joshua A., Oleaga, Carlota, Eren, Mesut, Amaral, Ansel P., Shang, Meng, Lux, Elizabeth, Khan, Sadiya S., Shah, Sanjiv J., Omura, Yasuhiro, Pamir, Nathalie, Hay, Joshua, Barish, Grant, Miyata, Toshio, Tavori, Hagai, Fazio, Sergio, Vaughan, Douglas E.

“…Plasminogen activator inhibitor 1 (PAI-1) is a functional biomarker of the metabolic syndrome. Previous studies have demonstrated that PAI-1 is a mechanistic…”
Get full text

Proprotein Convertase Subtilisin Kexin Type 9 Promotes Intestinal Overproduction of Triglyceride-Rich Apolipoprotein B Lipoproteins Through Both Low-Density Lipoprotein Receptor-Dependent and -Independent Mechanisms by RASHID, Shirya, TAVORI, Hagai, BROWN, Patrick E, LINTON, MacRae F, JANE HE, GIUNZIONI, Ilaria, FAZIO, Sergio

“…Proprotein convertase subtilisin kexin type 9 (PCSK9) promotes the degradation of the low-density lipoprotein (LDL) receptor (LDLR), and its deficiency in…”
Get full text

Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases C-C Chemokine Receptor Type 7 (CCR7) Expression in Plaque Macrophages by Mueller, Paul A, Zhu, Lin, Tavori, Hagai, Huynh, Katherine, Giunzioni, Ilaria, Stafford, John M, Linton, MacRae F, Fazio, Sergio

“…BACKGROUND:We previously showed that mice lacking MΦLRP1 (low-density lipoprotein receptor–related protein 1 in macrophages) undergo accelerated…”
Get full text

Local effects of human PCSK9 on the atherosclerotic lesion by Giunzioni, Ilaria, Tavori, Hagai, Covarrubias, Roman, Major, Amy S, Ding, Lei, Zhang, Youmin, DeVay, Rachel M, Hong, Liang, Fan, Daping, Predazzi, Irene M, Rashid, Shirya, Linton, MacRae F, Fazio, Sergio

“…Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes atherosclerosis by increasing low‐density lipoprotein (LDL) cholesterol levels through…”
Get full text

Human PCSK9 promotes hepatic lipogenesis and atherosclerosis development via apoE- and LDLR-mediated mechanisms by Tavori, Hagai, Giunzioni, Ilaria, Predazzi, Irene M, Plubell, Deanna, Shivinsky, Anna, Miles, Joshua, Devay, Rachel M, Liang, Hong, Rashid, Shirya, Linton, MacRae F, Fazio, Sergio

“…Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes the degradation of hepatic low-density lipoprotein (LDL) receptors (LDLR), thereby, decreasing…”
Get full text

Loss of Plasma Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) After Lipoprotein Apheresis by Tavori, Hagai, Giunzioni, Ilaria, Linton, MacRae F, Fazio, Sergio

“…RATIONALE:Lipoprotein apheresis (LA) reduces low-density lipoprotein (LDL) levels in patients with severe familial hypercholesterolemia (FH). We have recently…”
Get full text

Relationship Between Low-Density Lipoprotein Cholesterol and Lipoprotein(a) Lowering in Response to PCSK9 Inhibition With Evolocumab by Shapiro, Michael D, Minnier, Jessica, Tavori, Hagai, Kassahun, Helina, Flower, Andrea, Somaratne, Ransi, Fazio, Sergio

“…Background Beyond their potent LDL (low-density lipoprotein) cholesterol ( LDL -C)-lowering efficacy (50-60%), PCSK9 (proprotein convertase subtilisin/kexin…”
Get full text

PCSK9 by Shapiro, Michael D, Tavori Hagai, Fazio, Sergio

“…Unknown 15 years ago, PCSK9 (proprotein convertase subtilisin/kexin type 9) is now common parlance among scientists and clinicians interested in prevention and…”
Get full text

PMP22 is critical for actin-mediated cellular functions and for establishing lipid rafts by Lee, Sooyeon, Amici, Stephanie, Tavori, Hagai, Zeng, Waylon M, Freeland, Steven, Fazio, Sergio, Notterpek, Lucia

“…Haploinsufficiency of peripheral myelin protein 22 (PMP22) causes hereditary neuropathy with liability to pressure palsies, a peripheral nerve lesion induced…”
Get full text

Insights into the kinetics and dynamics of the furin-cleaved form of PCSK9 by Oleaga, Carlota, Hay, Joshua, Gurcan, Emma, David, Larry L., Mueller, Paul A., Tavori, Hagai, Shapiro, Michael D., Pamir, Nathalie, Fazio, Sergio

“…Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates cholesterol metabolism by inducing the degradation of hepatic low density lipoprotein receptors…”
Get full text

Development of a novel Guinea Pig model producing transgenerational endothelial transcriptional changes driven by maternal food restriction and a second metabolic insult of high fat diet by Le, Hillary H., Hagen, Matthew W., Louey, Samantha, Tavori, Hagai, Thornburg, Kent L., Giraud, George D., Hinds, Monica T., Barnes, Anthony P.

“…Developmental programming of chronic adverse cardiovascular health outcomes has been studied both using numerous human populations and an array of animal…”
Get full text

Macrophage apoAI protects against dyslipidemia-induced dermatitis and atherosclerosis without affecting HDL[S] by Tavori, Hagai, Su, Yan Ru, Yancey, Patricia G., Giunzioni, Ilaria, Wilhelm, Ashley J., Blakemore, John L., Zabalawi, Manal, Linton, MacRae F., Sorci-Thomas, Mary G., Fazio, Sergio

“…Tissue cholesterol accumulation, macrophage infiltration, and inflammation are features of atherosclerosis and some forms of dermatitis. HDL and its main…”
Get full text

Discordant response of low-density lipoprotein cholesterol and lipoprotein(a) levels to monoclonal antibodies targeting proprotein convertase subtilisin/kexin type 9 by Edmiston, Jonathan B., BS, Brooks, Nathan, MD, Tavori, Hagai, PhD, Minnier, Jessica, PhD, Duell, Bart, MD, Purnell, Jonathan Q., MD, Kaufman, Tina, PhD, PA-C, Wojcik, Cezary, MD, PhD, Voros, Szilard, MD, Fazio, Sergio, MD, PhD, Shapiro, Michael D., DO

“…Background Clinical trials testing proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) have demonstrated an unanticipated but significant…”
Get full text

Oxysterols formation as a reflection of biochemical pathways: summary of in vitro and in vivo studies by Vaya, Jacob, Szuchman, Andrea, Tavori, Hagai, Aluf, Yuval

“…► Oxysterols can be used as markers of OS in cells, tissues and organs. ► Their formation is affected by various parameters: the presence/level of ROS/RNS…”
Get full text

Angiotensin-induced abdominal aortic aneurysms in hypercholesterolemic mice: role of serum cholesterol and temporal effects of exposure by Prins, Petra A, Hill, Michael F, Airey, David, Nwosu, Sam, Perati, Prudhvidhar R, Tavori, Hagai, F Linton, Macrae, Kon, Valentina, Fazio, Sergio, Sampson, Uchechukwu K

“…Understanding variations in size and pattern of development of angiotensin II (Ang II)-induced abdominal aortic aneurysms (AAA) may inform translational…”
Get full text

Plasma Lipidomic Patterns in Patients with Symptomatic Coronary Microvascular Dysfunction by Lindner, Jonathan R., Davidson, Brian P., Song, Zifeng, Maier, Claudia S., Minnier, Jessica, Stevens, Jan Frederick, Ferencik, Maros, Taqui, Sahar, Belcik, J. Todd, Moccetti, Federico, Layoun, Michael, Spellman, Paul, Turker, Mitchell S., Tavori, Hagai, Fazio, Sergio, Raber, Jacob, Bobe, Gerd

“…Coronary microvascular dysfunction (MVD) is a syndrome of abnormal regulation of vascular tone, particularly during increased metabolic demand. While there are…”
Get full text

A case of severe acquired hypertriglyceridemia in a 7-year-old girl by Lilley, Jessica S., Linton, MacRae F., Kelley, Jennifer C., Graham, T. Brent, Fazio, Sergio, Tavori, Hagai

“…We report a case of severe type I hyperlipoproteinemia caused by autoimmunity against lipoprotein lipase (LPL) in the context of presymptomatic Sjögren's…”
Get full text

Macrophage-derived apoESendai suppresses atherosclerosis while causing lipoprotein glomerulopathy in hyperlipidemic mice[S] by Tavori, Hagai, Fan, Daping, Giunzioni, Ilaria, Zhu, Lin, Linton, MacRae F., Fogo, Agnes B., Fazio, Sergio

“…Lipoprotein glomerulopathy (LPG) is a renal disease often accompanied by dyslipidemia and increased serum apoE levels. apoESendai (Arg145Pro), a rare mutant…”
Get full text

PCSK9: From Basic Science Discoveries to Clinical Trials by Shapiro, Michael D, Tavori, Hagai, Fazio, Sergio

“…Unknown 15 years ago, PCSK9 (proprotein convertase subtilisin/kexin type 9) is now common parlance among scientists and clinicians interested in prevention and…”
Get full text