Search Results - "Tavassoly, Omid"

Inhibition of Brain Epidermal Growth Factor Receptor Activation: A Novel Target in Neurodegenerative Diseases and Brain Injuries by Tavassoly, Omid, Sato, Takashi, Tavassoly, Iman

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Pharmacological Inhibition of Brain EGFR Activation By a BBB-penetrating Inhibitor, AZD3759, Attenuates α-synuclein Pathology in a Mouse Model of α-Synuclein Propagation by Tavassoly, Omid, del Cid Pellitero, Esther, Larroquette, Frederique, Cai, Eddie, Thomas, Rhalena A., Soubannier, Vincent, Luo, Wen, Durcan, Thomas M., Fon, Edward A.

“…Aggregation and deposition of α-synuclein (α-syn) in Lewy bodies within dopamine neurons of substantia nigra (SN) is the pathological hallmark of Parkinson’s…”
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A light-inducible protein clustering system for in vivo analysis of α-synuclein aggregation in Parkinson disease by Bérard, Morgan, Sheta, Razan, Malvaut, Sarah, Rodriguez-Aller, Raquel, Teixeira, Maxime, Idi, Walid, Turmel, Roxanne, Alpaugh, Melanie, Dubois, Marilyn, Dahmene, Manel, Salesse, Charleen, Lamontagne-Proulx, Jérôme, St-Pierre, Marie-Kim, Tavassoly, Omid, Luo, Wen, Del Cid-Pellitero, Esther, Qazi, Raza, Jeong, Jae-Woong, Durcan, Thomas M, Vallières, Luc, Tremblay, Marie-Eve, Soulet, Denis, Lévesque, Martin, Cicchetti, Francesca, Fon, Edward A, Saghatelyan, Armen, Oueslati, Abid

“…Neurodegenerative disorders refer to a group of diseases commonly associated with abnormal protein accumulation and aggregation in the central nervous system…”
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Seeding of proteins into amyloid structures by metabolite assemblies may clarify certain unexplained epidemiological associations by Sade, Dorin, Shaham-Niv, Shira, Arnon, Zohar A., Tavassoly, Omid, Gazit, Ehud

“…The accumulation of various metabolites appears to be associated with diverse human diseases. However, the aetiological link between metabolic alteration and…”
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Nanopore analysis: An emerging technique for studying the folding and misfolding of proteins by Madampage, Claudia A., Tavassoly, Omid, Christensen, Chris, Kumari, Meena, Lee, Jeremy S.

“…Nanopore analysis is an emerging technique that enables the investigation of the conformation of a single peptide or protein molecule. Briefly, a pore is…”
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Heparin-binding Peptides as Novel Therapies to Stop SARS-CoV-2 Cellular Entry and Infection by Tavassoly, Omid, Safavi, Farinaz, Tavassoly, Iman

“…Heparan sulfate proteoglycans (HSPGs) are cell surface receptors that are involved in the cellular uptake of pathologic amyloid proteins and viruses, including…”
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EGFR Aggregation in the Brain by Tavassoly, Omid, Tavassoly, Iman

“…Recent findings showed that preformed fibrils (PFFs) of misfolded proteins, including α-synuclein (α-syn) and amyloid-β (Aβ), activate EGFR in cell cultures…”
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Seeding Brain Protein Aggregation by SARS-CoV‑2 as a Possible Long-Term Complication of COVID-19 Infection by Tavassoly, Omid, Safavi, Farinaz, Tavassoly, Iman

“…Postinfection complications of coronavirus disease 2019 (COVID-19) are still unknown, and one of the long-term concerns in infected people are brain…”
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Pharmacological inhibition and knockdown of O‐GlcNAcase reduces cellular internalization of α‐synuclein preformed fibrils by Tavassoly, Omid, Yue, Jefferey, Vocadlo, David J.

“…The pathological hallmark of Parkinson's disease (PD) is Lewy bodies that form within the brain from aggregated forms of α‐synuclein (α‐syn). These toxic α‐syn…”
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Pharmacological Functionalization of Protein-Based Nanorobots as a Novel Tool for Drug Delivery in Cancer by Tavassoly, Omid, Tavassoly, Iman

“…The delivery of hydrophobic therapeutic agents to tumors is a challenge in the treatment of cancers. Here, we review recent advances in coiled-coil protein…”
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Quinolinic Acid Amyloid-like Fibrillar Assemblies Seed α-Synuclein Aggregation by Tavassoly, Omid, Sade, Dorin, Bera, Santu, Shaham-Niv, Shira, Vocadlo, David J., Gazit, Ehud

“…Quinolinic acid (QA), a downstream neurometabolite in the kynurenine pathway, the biosynthetic pathway of tryptophan, is associated with neurodegenerative…”
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Methamphetamine binds to α-synuclein and causes a conformational change which can be detected by nanopore analysis by Tavassoly, Omid, Lee, Jeremy S.

“…► α-Synuclein translocates the α-hemolysin pore. ► In the presence of methamphetamine the proportion of translocation events is decreased. ► A conformational…”
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Cu(II) and dopamine bind to α‐synuclein and cause large conformational changes by Tavassoly, Omid, Nokhrin, Sergiy, Dmitriev, Oleg Y., Lee, Jeremy S.

“…α‐Synuclein (AS) is an intrinsically disordered protein that can misfold and aggregate to form Lewy bodies in dopaminergic neurons, a classic hallmark of…”
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The use of nanopore analysis for discovering drugs which bind to α-synuclein for treatment of Parkinson's disease by Tavassoly, Omid, Kakish, Joe, Nokhrin, Sergiy, Dmitriev, Oleg, Lee, Jeremy S.

“…A major feature of Parkinson's disease is the formation of Lewy bodies in dopaminergic neurons which consist of misfolded α-synuclein. The binding of natural…”
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SMPD1 mutations, activity, and α‐synuclein accumulation in Parkinson's disease by Alcalay, Roy N., Mallett, Victoria, Vanderperre, Benoît, Tavassoly, Omid, Dauvilliers, Yves, Wu, Richard Y.J., Ruskey, Jennifer A., Leblond, Claire S., Ambalavanan, Amirthagowri, Laurent, Sandra B., Spiegelman, Dan, Dionne‐Laporte, Alexandre, Liong, Christopher, Levy, Oren A., Fahn, Stanley, Waters, Cheryl, Kuo, Sheng‐Han, Chung, Wendy K., Ford, Blair, Marder, Karen S., Kang, Un Jung, Hassin‐Baer, Sharon, Greenbaum, Lior, Trempe, Jean‐Francois, Wolf, Pavlina, Oliva, Petra, Zhang, Xiaokui Kate, Clark, Lorraine N., Langlois, Melanie, Dion, Patrick A., Fon, Edward A., Dupre, Nicolas, Rouleau, Guy A., Gan‐Or, Ziv

“…Background SMPD1 (acid‐sphingomyelinase) variants have been associated with Parkinson's disease in recent studies. The objective of this study was to further…”
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Inhibition of Brain EGFR Activation: A Novel Target in Neurodegenerative Diseases and Brain Injuries by Tavassoly, Omid, Sato, Takashi, Tavassoly, Iman

“…Several reports have been published recently demonstrating a beneficial effect of epidermal growth factor receptor (EGFR) inhibitors in improving pathological…”
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Rasagiline, a Suicide Inhibitor of Monoamine Oxidases, Binds Reversibly to α‑Synuclein by Kakish, Joe, Tavassoly, Omid, Lee, Jeremy S

“…Rasagiline (N-propargyl-1-R-aminoindan) and selegiline (1-deprenyl) are MAO-B inhibitors which are used in the treatment of Parkinson’s disease. The binding of…”
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A light-inducible protein clustering system for in vivo analysis of [alpha]-synuclein aggregation in Parkinson disease by Bérard, Morgan, Sheta, Razan, Malvaut, Sarah, Rodriguez-Aller, Raquel, Teixeira, Maxime, Idi, Walid, Turmel, Roxanne, Alpaugh, Melanie, Dubois, Marilyn, Dahmene, Manel, Salesse, Charleen, Lamontagne-Proulx, Jérôme, St-Pierre, Marie-Kim, Tavassoly, Omid, Luo, Wen, Del Cid-Pellitero, Esther, Qazi, Raza, Jeong, Jae-Woong, Durcan, Thomas M, Vallières, Luc, Tremblay, Marie-Eve, Soulet, Denis, Lévesque, Martin, Cicchetti, Francesca, Fon, Edward A, Saghatelyan, Armen, Oueslati, Abid

“…Neurodegenerative disorders refer to a group of diseases commonly associated with abnormal protein accumulation and aggregation in the central nervous system…”
Get full text

Cu(II) and dopamine bind to [alpha]-synuclein and cause large conformational changes by Tavassoly, Omid, Nokhrin, Sergiy, Dmitriev, Oleg Y, Lee, Jeremy S

“…[alpha]-Synuclein (AS) is an intrinsically disordered protein that can misfold and aggregate to form Lewy bodies in dopaminergic neurons, a classic hallmark of…”
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Chaos game representation of mitochondrial DNA: is it useful in phylogenetic studies? by Tavassoly, Iman, Tavassoly, Omid, Rad, Mohammad SoltanyRezaee

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