Lactobacillus rhamnosus intake can prevent the development of Candidiasis

Lactobacillus rhamnosus intake can prevent the development of Candidiasis

Objective This study aimed to investigate the influence of Lactobacillus rhamnosus intake on the development of candidiasis and cytokines release. Material and methods Candida suspensions were inoculated into the oral cavity of experimentally immunosuppressed mice for candidiasis induction. The anim...

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Bibliographic Details
Published in:Clinical oral investigations Vol. 22; no. 7; pp. 2511 - 2518
Main Authors: Leão, Mariella Vieira Pereira, Tavares, Talita Angelina Aureliano, Gonçalves e Silva, Célia Regina, dos Santos, Silvana Soleo Ferreira, Junqueira, Juliana Campos, de Oliveira, Luciane Dias, Jorge, Antonio Olavo Cardoso
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-09-2018
Springer Nature B.V
Subjects:
Animals
Biomarkers - blood
Candida
Candidiasis
Candidiasis, Oral - prevention & control
Cytokines
Cytokines - blood
Dentistry
Disease Models, Animal
Fungi
Immunocompromised Host
Inflammation
Inoculation
Interleukin 1
Interleukin 10
Interleukin 12
Interleukin 4
Interleukin 6
Lactobacillus rhamnosus
Male
Medicine
Mice
Oral cavity
Original Article
Probiotics
Probiotics - pharmacology
Tumor necrosis factor-α
Probiotics
Cytokine
Candida
Lactobacillus rhamnosus
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Summary:Objective This study aimed to investigate the influence of Lactobacillus rhamnosus intake on the development of candidiasis and cytokines release. Material and methods Candida suspensions were inoculated into the oral cavity of experimentally immunosuppressed mice for candidiasis induction. The animals were divided into experimental groups: candidiasis with no probiotic intake (F), candidiasis with probiotic intake during Candida inoculation (FP), and candidiasis with probiotic intake 14 days before inoculation with Candida (FPP); and control groups: (C), (CP), and (CPP) without inducing candidiasis with probiotic intake in the same manner as groups F, FP, and FPP, respectively. After these periods, samples were collected from the oral cavity for yeast counts and, after euthanasia, the tongues of the animals were removed for histological analysis. Sera samples were also collected for analysis of IL-1 beta, TNF-alpha, INF-gamma, IL-12, IL-4, and IL-10. Results FP group showed lower Candida counts in the oral cavity, and the presence of Candida was almost not detected in FPP group. In tissues, the counts of fungi were significantly lower in FPP group, followed by FP. Groups that consumed probiotics also had lower histological and inflammatory infiltrates compared to F. Cytokines analysis demonstrated low concentrations of TNF-α, IL-12, IL-4, and IL-10 in all the groups, and no statistical difference between them. The production of IL-6 could be better detected, and the experimental groups that consumed the probiotic showed significant lower levels of this cytokine. Conclusions The results suggest that L. rhamnosus intake, especially preventively, may avoid or decrease the development of candidiasis in immunosuppressed mice. Clinical relevance This work adds scientific evidences that probiotics intake can avoid the development of candidiasis.
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ISSN:1432-6981
1436-3771
DOI:10.1007/s00784-018-2347-8