Chlamydia trachomatis infection and human papillomavirus in women with cervical neoplasia in Pernambuco-Brazil

Chlamydia trachomatis (CT) is the most common bacterial cause of sexually transmitted disease. High-risk human papillomavirus (HR-HPV) is considered the main etiological agent for cervical neoplasia. Evidences showed that the presence of co-infection of CT and HR-HPV plays a central role in the etio...

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Bibliographic Details
Published in:	Molecular biology reports Vol. 41; no. 2; pp. 865 - 874
Main Authors:	Tavares, Mayara Costa Mansur, de Macêdo, Jamilly Lopes, de Lima Júnior, Sérgio Ferreira, de Andrade Heráclio, Sandra, Amorim, Melânia Maria Ramos, de Mascena Diniz Maia, Maria, de Souza, Paulo Roberto Eleutério
Format:	Journal Article
Language:	English
Published:	Dordrecht Springer Netherlands 01-02-2014 Springer Nature B.V
Subjects:	Adolescent Adult Aged Animal Anatomy Animal Biochemistry Animals Biomedical and Life Sciences Brazil Cervical cancer Chlamydia Infections - epidemiology Chlamydia Infections - pathology Chlamydia Infections - virology Chlamydia trachomatis Chlamydia trachomatis - isolation & purification Chlamydia trachomatis - pathogenicity Coinfection Female Genotype Health risk assessment Histology Human papillomavirus Humans Life Sciences Middle Aged Morphology Papillomaviridae - genetics Papillomaviridae - pathogenicity Papillomavirus Infections - genetics Papillomavirus Infections - pathology Sexually transmitted diseases STD Uterine Cervical Neoplasms - epidemiology Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - virology Brazil Brazilian population Abnormal cytology Human papillomavirus Risk factors
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Summary:	Chlamydia trachomatis (CT) is the most common bacterial cause of sexually transmitted disease. High-risk human papillomavirus (HR-HPV) is considered the main etiological agent for cervical neoplasia. Evidences showed that the presence of co-infection of CT and HR-HPV plays a central role in the etiology of cervical intraepithelial neoplasia (CIN) and cervical cancer. The goals of this study were: evaluate the human papillomavirus (HPV) and CT prevalence among Brazilian women with abnormal cytology and provide the effect of this association on the severity of cervical neoplasia. The population of this study was composed by 142 women with incident histological incidence of CIN grades I, II, III or cervical cancer from Recife, Northeast of Brazil. The polymerase chain reaction method on a cervical brush specimen was used to detect both agents and the automatic sequencing method was used for HPV genotyping assay. The prevalence of HPV and CT was 100 and 24.65 %, respectively. Thirteen types of HPV were detected; HPV 16, 18, 31 and 33 were the most common. The most prevalent HPV types were HPV 16 and 18. A significant association between CT positive and HPV 16 infection was found ( p < 0.0106; OR = 5.31; 95 % IC 1.59–17.67). In the study population, there was diversity of HPV infections, with high-risk types being the most common. Also, the data collected suggest that CT infection may play an important role in the natural history of HPV infection.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0301-4851 1573-4978
DOI:	10.1007/s11033-013-2927-2