Uptake of lipid core nanoparticles by fragments of tissues collected during cerebral tumor excision surgeries: hypotheses for use in drug targeting therapy

Purpose Malignant cerebral tumors have poor prognosis and the blood–brain barrier is a major hindrance for most drugs to reach those tumors. Lipid nanoparticles (LDE) that bind to lipoprotein receptors may carry anticancer drugs and penetrate the cells through those receptors that are overexpressed...

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Bibliographic Details
Published in:	Journal of neuro-oncology Vol. 158; no. 3; pp. 413 - 421
Main Authors:	Pereira, Edmundo Luís Rodrigues, Feio, Danielle Cristinne Azevedo, Tavares, João Pojucan Lobo, Morikawa, Natalia Megumi, Deus, Debora Fernandes, Vital, Carolina Graziani, Tavares, Elaine Rufo, Maranhão, Raul Cavalcante
Format:	Journal Article
Language:	English
Published:	New York Springer US 01-07-2022 Springer Nature B.V
Subjects:	Antineoplastic drugs Antitumor agents Blood-brain barrier Brain cancer Brain tumors Cholesterol Clinical trials Dura mater Glioma Lipids Lipoprotein receptors Lymphoma Medicine Medicine & Public Health Metastases Metastasis Nanoparticles Neurology Oncology Periosteum Surgery Toxicity Tumors Glioma treatment Nanoemulsions LDL-receptor and cancer Solid lipid nanoparticles Blood–brain barrier
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Summary:	Purpose Malignant cerebral tumors have poor prognosis and the blood–brain barrier is a major hindrance for most drugs to reach those tumors. Lipid nanoparticles (LDE) that bind to lipoprotein receptors may carry anticancer drugs and penetrate the cells through those receptors that are overexpressed in gliomas. The aim was to investigate the in vivo uptake of LDE by human cerebral tumors. Methods Twelve consecutive patients (4 with glioblastomas, 1 meduloblastoma, 1 primary lymphoma, 2 with non-cerebral metastases and 4 with benign tumors) scheduled for tumor excision surgery were injected intravenously, 12 h before surgery, with LDE labeled 14 C-cholesterol oleate. Fragments of tumors and of normal head tissues (muscle, periosteum, dura mater) discarded by the surgeon were submitted to lipid extraction and radioactive counting. Results Tumor LDE uptake (range: 10–283 d.p.m./g of tissue) was not lower than that of normal tissues (range: 20–263 d.p.m./g). Malignant tumor uptake was threefold greater than benign tumor uptake (140 ± 93 vs 46 ± 18 d.p.m./g, p < 0.05). Results show that LDE can concentrate in brain malignant tumors and may be used to carry drugs directed against those tumors. Conclusion As LDE was previously shown to markedly decrease drug toxicity this new therapeutic strategy should be tested in future trials.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0167-594X 1573-7373
DOI:	10.1007/s11060-022-04028-1