Search Results - "Tavares, Ignatius A."

Targeting TAO Kinases Using a New Inhibitor Compound Delays Mitosis and Induces Mitotic Cell Death in Centrosome Amplified Breast Cancer Cells by Koo, Chuay-Yeng, Giacomini, Caterina, Reyes-Corral, Marta, Olmos, Yolanda, Tavares, Ignatius A, Marson, Charles M, Linardopoulos, Spiros, Tutt, Andrew N, Morris, Jonathan D H

“…Thousand-and-one amino acid kinases (TAOK) 1 and 2 are activated catalytically during mitosis and can contribute to mitotic cell rounding and spindle…”
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A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies by Giacomini, Caterina, Koo, Chuay-Yeng, Yankova, Natalia, Tavares, Ignatius A, Wray, Selina, Noble, Wendy, Hanger, Diane P, Morris, Jonathan D H

“…In Alzheimer's disease (AD) and related tauopathies, the microtubule-associated protein tau is highly phosphorylated and aggregates to form neurofibrillary…”
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Prostate-derived Sterile 20-like Kinase 2 (PSK2) Regulates Apoptotic Morphology via C-Jun N-terminal Kinase and Rho Kinase-1 by Zihni, Ceniz, Mitsopoulos, Costas, Tavares, Ignatius A., Ridley, Anne J., Morris, Jonathan D.H.

“…We have reported previously that human prostate-derived sterile 20-like kinase (PSK) 1 alters actin cytoskeletal organization and binds to microtubules,…”
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Effect of the flavonoid galangin on urinary bladder rat contractility in-vitro by Capasso, Raffaele, Tavares, Ignatius A.

“…Galangin is a flavanol with several biological activities. We have evaluated the effect of galangin on the contractile response elicited by electrical field…”
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Prostate-derived Sterile 20-like Kinases (PSKs/TAOKs) Are Activated in Mitosis and Contribute to Mitotic Cell Rounding and Spindle Positioning by Wojtala, Rachael L., Tavares, Ignatius A., Morton, Penny E., Valderrama, Ferran, Thomas, N. Shaun B., Morris, Jonathan D.H.

“…Prostate-derived sterile 20-like kinases (PSKs) 1-α, 1-β, and 2 are members of the germinal-center kinase-like sterile 20 family of kinases. Previous work has…”
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Prostate-derived Sterile 20-like Kinases (PSKs/TAOKs) Phosphorylate Tau Protein and Are Activated in Tangle-bearing Neurons in Alzheimer Disease by Tavares, Ignatius A., Touma, Dona, Lynham, Steven, Troakes, Claire, Schober, Megan, Causevic, Mirsada, Garg, Ritu, Noble, Wendy, Killick, Richard, Bodi, Istvan, Hanger, Diane P., Morris, Jonathan D.H.

“…In Alzheimer disease (AD), the microtubule-associated protein tau is highly phosphorylated and aggregates into characteristic neurofibrillary tangles…”
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Prostate-derived Sterile 20-like Kinase 1-α Induces Apoptosis: JNK- AND CASPASE-DEPENDENT NUCLEAR LOCALIZATION IS A REQUIREMENT FOR MEMBRANE BLEBBING by Zihni, Ceniz, Mitsopoulos, Costas, Tavares, Ignatius A, Baum, Buzz, Ridley, Anne J, Morris, Jonathan D.H

“…We have demonstrated previously that full-length prostate-derived sterile 20-like kinase 1-α (PSK1-α) binds to microtubules via its C terminus and regulates…”
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Non-steroidal anti-inflammatory drugs that cause relatively little gastric damage by TAVARES, IGNATIUS A, BENNETT, ALAN

“…Gastrointestinal damage by non‐steroidal anti‐inflammatory drugs (NSAID), which is common and sometimes fatal, involves inhibition of prostaglandin (PG)…”
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Prostate-derived Sterile 20-like Kinase 1-α Induces Apoptosis by Zihni, Ceniz, Mitsopoulos, Costas, Tavares, Ignatius A., Baum, Buzz, Ridley, Anne J., Morris, Jonathan D.H.

“…We have demonstrated previously that full-length prostate-derived sterile 20-like kinase 1-α (PSK1-α) binds to microtubules via its C terminus and regulates…”
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Prostate-derived Sterile 20-like Kinase 1-α Induces Apoptosis by Ceniz Zihni, Costas Mitsopoulos, Ignatius A. Tavares, Buzz Baum, Anne J. Ridley, Jonathan D. H. Morris

“…We have demonstrated previously that full-length prostate-derived sterile 20-like kinase 1-α (PSK1-α) binds to microtubules via its C terminus and regulates…”
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COX-2 inhibitors compared and contrasted by Bennett, A, Tavares, I A

“…Non-steroidal anti-inflammatory drugs (NSAIDs) are the principal drug treatments for inflammation, pain and fever. They act primarily by inhibiting…”
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Loading‐related increases in prostaglandin production in cores of adult canine cancellous bone in vitro: A role for prostacyclin in adaptive bone remodeling? by Rawlinson, Simon C.F., El‐Haj, Alicia J., Minter, Sarah L., Tavares, Ignatius A., Bennett, Alan, Lanyon, Lance E.

“…Cyclic mechanical loading sufficient to engender strains of physiologic magnitude applied to recently excised canine cancellous bone cores in vitro increased…”
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NSAIDs, Cox-2 inhibitors, and the gut by Bennett, A, Tavares, I A

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A robust method for evaluation of NANC transmission in human sigmoid colon muscle in vitro by Tavares, Ignatius A., Rennie, John A.

“…Introduction: Human tissues are notoriously difficult to work with, giving results that are quantitatively variable within and between studies. Hence, previous…”
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Eicosanoid formation by mammalian intestine. Effects of some intestinal secretagogues by Capasso, F, Tavares, I A, Tsang, R, Rennie, J A, Bennett, A

“…Intestinal tissues of man, rat, mouse, guinea-pig and rabbit were preincubated with laxatives, homogenised, and incubated with [14C]arachidonic acid. After…”
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The biological activities of phthalate esters on rat gastric muscle by Tavares, I A, Bennett, A, Gaffen, J D, Morris, H R, Taylor, G W

“…Monoethylhexyl phthalate, at concentrations that can occur in blood stored in plastic bags (0.1-0.5 mg/ml), reduced contractions of rat isolated gastric fundus…”
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