Search Results - "Tavaré, S"

BioHMM: a heterogeneous hidden Markov model for segmenting array CGH data by Marioni, J. C., Thorne, N. P., Tavaré, S.

“…We have developed a new method (BioHMM) for segmenting array comparative genomic hybridization data into states with the same underlying copy number. By…”
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Using array-comparative genomic hybridization to define molecular portraits of primary breast cancers by CHIN, S.-F, WANG, Y, IYER, N. G, KRANJAC, T, ROBERTSON, J. F. R, APARICIO, S, TAVARE, S, ELLIS, I, BRENTON, J. D, CALDAS, C, THORNE, N. P, TESCHENDORFF, A. E, PINDER, S. E, VIAS, M, NADERI, A, ROBERTS, I, BARBOSA-MORAIS, N. L, GARCIA, M. J

“…We analysed 148 primary breast cancers using BAC-arrays containing 287 clones representing cancer-related gene/loci to obtain genomic molecular portraits…”
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O039 The interferonscape: Systems biology of interferon stimulated pathways and networks by Samarajiwa, S.A., Spiteri, I., Lynch, A., Jauhiainen, A., Morrissey, E., Cairns, J., Narita, M., Tavaré, S.

“…The Interferons (IFNs) are a family of pleiotropic cytokines that mediate anti-microbial, anti-proliferative, anti-tumour, immuno-modulatory and homoeostatic…”
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Recombination in the ompA gene but not the omcB gene of Chlamydia contributes to serovar-specific differences in tissue tropism, immune surveillance, and persistence of the organism by Millman, K L, Tavaré, S, Dean, D

“…Sequences of the major outer membrane protein (MOMP) gene (ompA) and the outer membrane complex B protein gene (omcB) from Chlamydia trachomatis, Chlamydia…”
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Genetic Reconstruction of Individual Colorectal Tumor Histories by Tsao, Jen-Lan, Yatabe, Yasushi, Salovaara, Reijo, Jarvinen, Heikki J., Mecklin, Jukka-Pekka, Aaltonen, Lauri A., Tavare, Simon, Shibata, Darryl

“…It is difficult to observe human tumor progression as precursor lesions are systematically removed. Alternatives to direct observations, commonly used to…”
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Analysis of Germline Mutation Spectra at the Huntington's Disease Locus Supports a Mitotic Mutation Mechanism by Leeflang, Esther P., Tavaré, Simon, Marjoram, Paul, Neal, Carolyn O. S., Srinidhi, Jayalakshmi, MacFarlane, Heather, MacDonald, Marcy E., Gusella, James F., de Young, Margot, Wexler, Nancy S., Arnheim, Norman

“…Trinucleotide repeat disease alleles can undergo ‘dynamic’ mutations in which repeat number may change when a gene is transmitted from parent to offspring. By…”
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Single sperm analysis of the trinucleotide repeats in the Huntington's disease gene: quantification of the mutation frequency spectrum by Leeflang, E P, Zhang, L, Tavaré, S, Hubert, R, Srinidhi, J, MacDonald, M E, Myers, R H, de Young, M, Wexler, N S, Gusella, J F

“…The CAG triplet repeat region of the Huntington's disease gene was amplified in 923 single sperm from three affected and two normal individuals. Average-size…”
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Investigating Stem Cells in Human Colon by Using Methylation Patterns by Yatabe, Yasushi, Tavaré, Simon, Shibata, Darryl

“…The stem cells that maintain human colon crypts are poorly characterized. To better determine stem cell numbers and how they divide, epigenetic patterns were…”
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Colorectal Adenoma and Cancer Divergence : Evidence of Multilineage Progression by Tsao, Jen-Lan, Tavare, Simon, Salovaara, Reijo, Jass, Jeremy R, Aaltonen, Lauri A, Shibata, Darryl

“…Colorectal cancer progression involves changes in phenotype and genotype. Although usually illustrated as a linear process, more complex underlying pathways…”
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825 Towards a systems-level view of breast cancer through the joint analysis of multi-dimensional data by Curtis, C, Chin, S.F, Shah, S.P, Tavaré, S, Aparicio, S, Caldas, C

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On a test of Depaulis and Veuille by Markovtsova, L, Marjoram, P, Tavare, S

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Spatial and Temporal Distribution of the Neutral Polymorphisms in the Last ZFX Intron: Analysis of the Haplotype Structure and Genealogy by Jaruzelska, Jadwiga, Zietkiewicz, Ewa, Batzer, Mark, Cole, David E. C, Moisan, Jean-Paul, Scozzari, Rosaria, Tavare, Simon, Labuda, Damian

“…With 10 segregating sites (simple nucleotide polymorphisms) in the last intron (1089 bp) of the ZFX gene we have observed 11 haplotypes in 336 chromosomes…”
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Inferring Coalescence Times From DNA Sequence Data by Tavare, S, Balding, D. J, Griffiths, R. C, Donnelly, P

“…The paper is concerned with methods for the estimation of the coalescence time (time since the most recent common ancestor) of a sample of intraspecies DNA…”
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Estimating the age of the common ancestor of men from the ZFY intron by Donnelly, P, Tavaré, S, Balding, D J, Griffiths, R C

“…Dorit et al. used polymorphism on the Y chromosome to infer aspects of human population history. They found an absence of sequence variation in a worldwide…”
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Monte Carlo inference methods in population genetics by Griffiths, R.C., Tavaré, S.

“…We study the distribution of summary statistics of the sample configuration of DNA sequences taken from a large population that has evolved with…”
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Estimating Substitution Rates from Molecular Data Using the Coalescent by Lundstrom, Ron, Tavare, Simon, Ward, R. H.

“…A coalescent model is used to estimate the rate at which neutral substitutions occur in a DNA sequence, without the necessity for an independent estimate of…”
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Imaging mass cytometry and multiplatform genomics define the phenogenomic landscape of breast cancer by Ali, H Raza, Jackson, Hartland W, Zanotelli, Vito R T, Danenberg, Esther, Fischer, Jana R, Bardwell, Helen, Provenzano, Elena, Rueda, Oscar M, Chin, Suet-Feung, Aparicio, Samuel, Caldas, Carlos, Bodenmiller, Bernd

“…Genomic alterations shape cell phenotypes and the structure of tumor ecosystems in poorly defined ways. To investigate these relationships, we used imaging…”
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Three-dimensional imaging mass cytometry for highly multiplexed molecular and cellular mapping of tissues and the tumor microenvironment by Kuett, Laura, Catena, Raúl, Özcan, Alaz, Plüss, Alex, Schraml, Peter, Moch, Holger, de Souza, Natalie, Bodenmiller, Bernd

“…A holistic understanding of tissue and organ structure and function requires the detection of molecular constituents in their original three-dimensional (3D)…”
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Coalescents and Genealogical Structure Under Neutrality by Donnelly, P, Tavare, S

“…Genealogical or coalescent methods have proved very useful in interpreting and understanding a wide range of population genetic data. Our aim is to illustrate…”
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O4.05 GENETIC DIVERSITY AND INTRA-TUMOR HETEROGENEITY IN HUMAN GLIOBLASTOMA by Piccirillo, S. G. M., Spiteri, I., Sottoriva, A., Touloumis, A., Collins, P., Curtis, C., Marioni, J., Tavare', S., Watts, C.

“…BACKGROUND: Glioblastoma (GB) is the most common and aggressive primary brain malignancy. The disease is advanced at the time of clinical presentation and…”
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