Search Results - "Tavaré, J M"

Akt phosphorylation on Thr308 but not on Ser473 correlates with Akt protein kinase activity in human non-small cell lung cancer by Vincent, E E, Elder, D J E, Thomas, E C, Phillips, L, Morgan, C, Pawade, J, Sohail, M, May, M T, Hetzel, M R, Tavaré, J M

“…Background: The activity of the protein kinase Akt is frequently dysregulated in cancer and is an important factor in the growth and survival of tumour cells…”
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Subcellular Imaging of Intramitochondrial Ca2+ with Recombinant Targeted Aequorin: Significance for the Regulation of Pyruvate Dehydrogenase Activity by Rutter, Guy A., Burnett, Paul, Rizzuto, Rosario, Brini, Marisa, Murgia, Marta, Pozzan, Tullio, Tavaré, Jeremy M., Denton, Richard M.

“…Specific targeting of the recombinant, Ca2+-sensitive photoprotein, aequorin to intracellular organelles has provided new insights into the mechanisms of…”
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Rosiglitazone enhances glucose uptake in glomerular podocytes using the glucose transporter GLUT1 by Lennon, R, Welsh, G. I, Singh, A, Satchell, S. C, Coward, R. J, Tavaré, J. M, Mathieson, P. W, Saleem, M. A

“…Aims/hypothesis Peroxisome proliferator-activated receptor (PPAR) γ agonists are used increasingly in the treatment of type 2 diabetes. In the context of renal…”
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Studies on the autophosphorylation of the insulin receptor from human placenta. Analysis of the sites phosphorylated by two-dimensional peptide mapping by Tavaré, J M, Denton, R M

“…1. A partially purified preparation of human placental insulin receptors was incubated with [gamma-32P]ATP in the presence or absence of insulin. The…”
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Analysis of insulin-receptor phosphorylation sites in intact cells by two-dimensional phosphopeptide mapping by Tavaré, J M, O'Brien, R M, Siddle, K, Denton, R M

“…Insulin stimulates the autophosphorylation of the partially purified insulin receptor initially on tyrosine residues 1146, 1150 and 1151. This is followed by…”
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Divergent signalling mechanisms involved in insulin-stimulated GLUT4 vesicle trafficking to the plasma membrane by Fletcher, L M, Tavaré, J M

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Central Role for Phosphatidylinositide 3-Kinase in the Repression of Glucose-6-phosphatase Gene Transcription by Insulin by Dickens, Martin, Svitek, Christina A., Culbert, Ainsley A., O'Brien, Richard M., Tavaré, Jeremy M.

“…Transcription of the gene encoding the catalytic subunit of glucose-6-phosphatase (G6Pase) is stimulated by glucocorticoids and strongly repressed by insulin…”
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Rapid caspase-3 activation during apoptosis revealed using fluorescence-resonance energy transfer by Tyas, Lorraine, Brophy, Victoria A, Pope, Andrew, Rivett, A Jennifer, Tavaré, Jeremy M

“…Caspase‐3 is a crucial component of the apoptotic machinery in many cell types. Here, we report the timescale of caspase‐3 activation in single living cells…”
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Role of protein kinase B in insulin-regulated glucose uptake by Welsh, G I, Hers, I, Berwick, D C, Dell, G, Wherlock, M, Birkin, R, Leney, S, Tavaré, J M

“…The activation of protein kinase B (or Akt) plays a central role in the stimulation of glucose uptake by insulin. Currently, however, numerous questions remain…”
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Using green fluorescent protein to study intracellular signalling by Tavare, JM, Fletcher, LM, Welsh, GI

“…Subcellular compartmentalisation of signalling molecules is an important phenomenon not only in defining how a signalling pathway is activated but also in…”
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Identification of in vivo brain-derived neurotrophic factor-stimulated autophosphorylation sites on the TrkB receptor tyrosine kinase by site-directed mutagenesis by Guiton, M, Gunn-Moore, F J, Stitt, T N, Yancopoulos, G D, Tavaré, J M

“…Brain-derived neurotrophic factor (BDNF) interacts with the TrkB receptor tyrosine kinase, the tyrosine kinase domain of which has homology with the insulin…”
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Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase by WELSH, G. I, FOULSTONE, E. J, YOUNG, S. W, TAVARE, J. M, PROUD, C. G

“…We have previously shown that insulin causes inactivation of glycogen synthase kinase-3 (GSK-3) in Chinese hamster ovary cells over-expressing the human…”
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Role for the microtubule cytoskeleton in GLUT4 vesicle trafficking and in the regulation of insulin-stimulated glucose uptake by Fletcher, L M, Welsh, G I, Oatey, P B, Tavaré, J M

“…Insulin stimulates glucose uptake into adipocytes by promoting the translocation of the glucose transporter isoform 4 (GLUT4) from intracellular vesicles to…”
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Naturally Occurring Tyrosine Kinase Inserts Block High Affinity Binding of Phospholipase Cγ and Shc to TrkC and Neurotrophin-3 Signaling (∗) by Guiton, Michelle, Gunn-Moore, Frank J., Glass, David J., Geis, David R., Yancopoulos, George D., Tavaré, Jeremy M.

“…Neurotrophin-3 binds to the receptor tyrosine kinase, TrkC. Several naturally occurring splice variants of TrkC exist including those with 14- and 39-amino…”
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Progress Toward Understanding the Molecular Mechanisms of Neurotrophic Factor Signalling by Gunn-Moore, F J, Tavare, J M

“…Understanding the mechanism of action of the neurotrophic factors is central to unravelling of the mysteries of some of the neurodegenerative disorders. In…”
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The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity by Hers, Ingeborg, Tavaré, Jeremy M, Denton, Richard M

“…Here we report that the widely used protein kinase C inhibitors, bisindolylmaleimide I and IX, are potent inhibitors of glycogen synthase kinase-3 (GSK-3)…”
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Site-specific anti-phosphopeptide antibodies: use in assessing insulin receptor serine/threonine phosphorylation state and identification of serine-1327 as a novel site of phorbol ester-induced phosphorylation by Coghlan, M P, Pillay, T S, Tavaré, J M, Siddle, K

“…Rabbit antisera were raised against synthetic phosphopeptides corresponding to defined or putative sites of insulin receptor serine/threonine phosphorylation…”
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Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3-kinase by Venkateswarlu, Kanamarlapudi, Oatey, Paru B., Tavaré, Jeremy M., Cullen, Peter J.

“…ADP-ribosylation factors (ARFs) are small GTP-binding proteins that are regulators of vesicle trafficking in eukaryotic cells [1]. ARNO is a member of the…”
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Molecular mechanisms of insulin-stimulated glucose uptake in adipocytes by DUCLUZEAU, P.-H, FLETCHER, L. M, VIDAL, H, LAVILLE, M, TAVARE, J. M

“…The stimulation of muscle and adipose tissue glucose metabolism, which is ultimately responsible for bringing about post-absorptive blood glucose clearance, is…”
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Differentiation of PC12 cells in response to a cAMP analogue is accompanied by sustained activation of mitogen-activated protein kinase: Comparison with the effects of insulin, growth factors and phorbol esters by Young, Stephen W., Dickens, Martin, Tavaré, Jeremy M.

“…It has been proposed previously that the sustained activation of mitogen-activated protein kinase may be necessary for the differentiation of PC12 cells…”
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