Efficacy of Chlorhexidine Varnish for the Prevention of Adult Caries A Randomized Trial

The Prevention of Adult Caries Study, an NIDCR-funded multicenter, double-blind, randomized clinical trial, enrolled 983 adults (aged 18-80 yrs) at high risk for developing caries (20 or more intact teeth and 2 or more lesions at screening) to test the efficacy of a chlorhexidine diacetate 10% weigh...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of dental research Vol. 91; no. 2; pp. 150 - 155
Main Authors:	Papas, A.S., Vollmer, W.M., Gullion, C.M., Bader, J., Laws, R., Fellows, J., Hollis, J.F., Maupomé, G., Singh, M.L., Snyder, J., Blanchard, P., White, Alex, Blanchard, Peter, Deane, Joy-Ann, Hamburger, Keith, Johnson, Joanne, Johnson, Kristen, Marangi-Marsden, Rosemary, Molina, Nydia, O’Connor, Kimberly, Tavano, Joanne, Torresyap, Gay, Maupome, Gerardo, Begay, Marilyn, Goldtooth, Tracy, Haskie, Jacqueline, Honanie, Eric, Masaquaptewa, Adrinne, Oh, Junhie, Peaches, Rantreva, Phipps, Kathy, Robertson, L.D., Ryczek, Shelli, Talayumptewa, Corina, Papas, Athena, Arkema, Elizabeth, Brown, Ashley, Burns, Virginia, Casey, Moira, Corrado, Pamela, Douglas, Mark, Ganda, Kachan, Gulati, Harish, Harrington, Dorothy, Krizova, Lucie, Lee, Karen, O’Connor, Julie, Ragone, Lauren, Russell, David, Singh, Medha, Singh, Mabi, Soter, John Cleeve, Stevens, George, Sundaralingam, Shankeertha, Tzavaras, Elizabeth, Snyder, John, Bernel, Diane, Brittan, John, Brooks, Leah, Carlston, Jennifer, Cheek, Paul, Clark, Donna, Downing, Joyce, Farrell, Kelsie, Gleason, Donna, Hankins, Janet, Hollis, Jack, Johnson, Cheryl, LaFerriere, Dan, Little, Sally Jo, Massinger, Lisa, Muessig, Kristin, Olson, Ora Lee, Richards, Kim, Snyder, Craig, Strong, Barbara, Vollmer, William M., Bader, James, Bardsley, Jeanette, Booker, Kristina, Chen, Chuhe, Chen, Ping, Dixon, Arthor, Donald, Judy, Elder, Charles, Fellows, Jeffrey, Funkhouser, Kimberly, Giullion, Christina, Kirk, Kelly, Laws, Reesa, Machen, Celeste, Meltesen, Gayle, Rasathurai, Sumithran, Reck, Deborah
Format:	Journal Article
Language:	English
Published:	Los Angeles, CA SAGE Publications 01-02-2012
Subjects:	Administration, Topical Adolescent Adult Aged Aged, 80 and over Anti-Infective Agents, Local - administration & dosage Chlorhexidine - administration & dosage Crowns Dental Caries - classification Dental Caries - prevention & control Dental Caries Susceptibility - drug effects Dental Enamel - drug effects Dental Enamel - pathology Dental Restoration, Permanent Dentin - drug effects Dentin - pathology Dentistry Disease Progression DMF Index Double-Blind Method Female Follow-Up Studies Humans Male Middle Aged Placebos Research Reports Root Caries - prevention & control Tooth Loss - classification Tooth Root - drug effects Tooth Root - pathology Treatment Outcome Young Adult chlorhexidine coating RCT-Randomized Clinical Trial prevention adults caries
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The Prevention of Adult Caries Study, an NIDCR-funded multicenter, double-blind, randomized clinical trial, enrolled 983 adults (aged 18-80 yrs) at high risk for developing caries (20 or more intact teeth and 2 or more lesions at screening) to test the efficacy of a chlorhexidine diacetate 10% weight per volume (w/v) dental coating (CHX). We excluded participants for whom the study treatment was contraindicated or whose health might affect outcomes or ability to complete the study. Participants were randomly assigned to receive either the CHX coating (n = 490) or a placebo control (n = 493). Coatings were applied weekly for 4 weeks and a fifth time 6 months later. The primary outcome (total net D1-2FS increment) was the sum of weighted counts of changes in tooth surface status over 13 months. We observed no significant difference between the two treatment arms in either the intention-to-treat or per-protocol analyses. Analysis of 3 protocol-specified secondary outcomes produced similar findings. This trial failed to find that 10% (w/v) chlorhexidine diacetate coating was superior to placebo coating for the prevention of new caries (Clinicaltrials.gov registration number NCT00357877).
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-News-2 ObjectType-Feature-3 content type line 23 Alex White DDS, DrPH, MS; Peter Blanchard DDS, MBA; Joy-Ann Deane DDS; Keith Hamburger RDH; Joanne Johnson RDH; Kristen Johnson RDH; Rosemary Marangi-Marsden RDH; Nydia Molina DA; Kimberly O’Connor CDA; Joanne Tavano CDA; Gay Torresyap RDH, MS, CCRC Athena Papas DMD, PhD; Elizabeth Arkema BS; Ashley Brown BS; Virginia Burns BS, RDH; Moira Casey BS; Pamela Corrado BS; Mark Douglas DH; Kachan Ganda MD; Harish Gulati DMD; Dorothy Harrington BS; Lucie Krizova MPH; Karen Lee BS; Julie O’Connor BS, DH; Lauren Ragone BS; David Russell DMD, MPH; Medha Singh BDS, MS; Mabi Singh BDS, MS; John Cleeve Soter BS DH; George Stevens DMD; Shankeertha Sundaralingam BS, MS; Elizabeth Tzavaras DA John Snyder DMD; Diane Bernel RDH; John Brittan DMD; Leah Brooks CRSI; Jennifer Carlston CRSII; Paul Cheek; Donna Clark CRSII; Joyce Downing; Kelsie Farrell CRSII; Donna Gleason; Janet Hankins RDH; Jack Hollis PhD; Cheryl Johnson EdM; Dan LaFerriere RN; Sally Jo Little RDH; Lisa Massinger; Kristin Muessig CRSII; Ora Lee Olson RDH; Kim Richards CRSI; Craig Snyder DMD; Barbara Strong Gerardo Maupome BDS, MSc, PhD; Marilyn Begay; Tracy Goldtooth; Jacqueline Haskie; Eric Honanie; Adrinne Masaquaptewa; Junhie Oh DDS, MPH; Rantreva Peaches; Kathy Phipps PhD, DDS; L.D. Robertson MD, MPH; Shelli Ryczek RDH, BS; Corina Talayumptewa; TCRHCC officers and staff; NNHRRB officers and staff William M. Vollmer PhD; James Bader DDS, MPH; Jeanette Bardsley; Kristina Booker BS; Chuhe Chen PhD; Ping Chen MS; Arthor Dixon MS; Judy Donald MA; Charles Elder MD, MPH; Jeffrey Fellows PhD; Kimberly Funkhouser BS; Christina Giullion PhD; Kelly Kirk; Reesa Laws BS; Celeste Machen; Gayle Meltesen MS; Sumithran Rasathurai PhD; Deborah Reck
ISSN:	0022-0345 1544-0591
DOI:	10.1177/0022034511424154