Search Results - "Tautenhahn, Ralf"

Highly sensitive feature detection for high resolution LC/MS by Tautenhahn, Ralf, Böttcher, Christoph, Neumann, Steffen

“…Liquid chromatography coupled to mass spectrometry (LC/MS) is an important analytical technology for e.g. metabolomics experiments. Determining the boundaries,…”
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XCMS Online: A Web-Based Platform to Process Untargeted Metabolomic Data by Tautenhahn, Ralf, Patti, Gary J, Rinehart, Duane, Siuzdak, Gary

“…Recently, interest in untargeted metabolomics has become prevalent in the general scientific community among an increasing number of investigators. The…”
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CAMERA: An Integrated Strategy for Compound Spectra Extraction and Annotation of Liquid Chromatography/Mass Spectrometry Data Sets by Kuhl, Carsten, Tautenhahn, Ralf, Böttcher, Christoph, Larson, Tony R, Neumann, Steffen

“…Liquid chromatography coupled to mass spectrometry is routinely used for metabolomics experiments. In contrast to the fairly routine and automated data…”
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An accelerated workflow for untargeted metabolomics using the METLIN database by Tautenhahn, Ralf, Cho, Kevin, Uritboonthai, Winnie, Zhu, Zhengjiang, Patti, Gary J, Siuzdak, Gary

“…Metabolites, which are typically recognized as small molecules that are involved in cellular reactions, provide a functional signature of phenotype that is…”
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Meta-analysis of untargeted metabolomic data from multiple profiling experiments by Patti, Gary J, Tautenhahn, Ralf, Siuzdak, Gary

“…metaXCMS is a software program for the analysis of liquid chromatography/mass spectrometry–based untargeted metabolomic data. It is designed to identify the…”
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The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming by Panopoulos, Athanasia D, Yanes, Oscar, Ruiz, Sergio, Kida, Yasuyuki S, Diep, Dinh, Tautenhahn, Ralf, Herrerías, Aída, Batchelder, Erika M, Plongthongkum, Nongluk, Lutz, Margaret, Berggren, W Travis, Zhang, Kun, Evans, Ronald M, Siuzdak, Gary, Belmonte, Juan Carlos Izpisua

“…Metabolism is vital to every aspect of cell function, yet the metabolome of induced pluripotent stem cells （iPSCs） remains largely unexplored. Here we report,…”
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Expanding Coverage of the Metabolome for Global Metabolite Profiling by Yanes, Oscar, Tautenhahn, Ralf, Patti, Gary J, Siuzdak, Gary

“…Mass spectrometry-based metabolomics is the comprehensive study of naturally occurring small molecules collectively known as the metabolome. Given the vast…”
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Critical assessment of alignment procedures for LC-MS proteomics and metabolomics measurements by Lange, Eva, Tautenhahn, Ralf, Neumann, Steffen, Gröpl, Clemens

“…Liquid chromatography coupled to mass spectrometry (LC-MS) has become a prominent tool for the analysis of complex proteomics and metabolomics samples. In many…”
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Toward ‘Omic Scale Metabolite Profiling: A Dual Separation–Mass Spectrometry Approach for Coverage of Lipid and Central Carbon Metabolism by Ivanisevic, Julijana, Zhu, Zheng-Jiang, Plate, Lars, Tautenhahn, Ralf, Chen, Stephen, O’Brien, Peter J, Johnson, Caroline H, Marletta, Michael A, Patti, Gary J, Siuzdak, Gary

“…Although the objective of any ‘omic science is broad measurement of its constituents, such coverage has been challenging in metabolomics because the metabolome…”
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Autonomous Metabolomics for Rapid Metabolite Identification in Global Profiling by Benton, H. Paul, Ivanisevic, Julijana, Mahieu, Nathaniel G, Kurczy, Michael E, Johnson, Caroline H, Franco, Lauren, Rinehart, Duane, Valentine, Elizabeth, Gowda, Harsha, Ubhi, Baljit K, Tautenhahn, Ralf, Gieschen, Andrew, Fields, Matthew W, Patti, Gary J, Siuzdak, Gary

“…An autonomous metabolomic workflow combining mass spectrometry analysis with tandem mass spectrometry data acquisition was designed to allow for simultaneous…”
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Metabolomics implicates altered sphingolipids in chronic pain of neuropathic origin by Patti, Gary J., Yanes, Oscar, Shriver, Leah P, Courade, Jean-Phillipe, Tautenhahn, Ralf, Manchester, Marianne, Siuzdak, Gary

“…Untargeted metabolomics reveals a dysregulation of sphingolipid production during neuropathic pain exemplified by N , N -dimethylsphingosine, whose…”
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An Untargeted Metabolomic Workflow to Improve Structural Characterization of Metabolites by Nikolskiy, Igor, Mahieu, Nathaniel G, Chen, Ying-Jr, Tautenhahn, Ralf, Patti, Gary J

“…Mass spectrometry-based metabolomics relies on MS2 data for structural characterization of metabolites. To obtain the high-quality MS2 data necessary to…”
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A View from Above: Cloud Plots to Visualize Global Metabolomic Data by Patti, Gary J, Tautenhahn, Ralf, Rinehart, Duane, Cho, Kevin, Shriver, Leah P, Manchester, Marianne, Nikolskiy, Igor, Johnson, Caroline H, Mahieu, Nathaniel G, Siuzdak, Gary

“…Global metabolomics describes the comprehensive analysis of small molecules in a biological system without bias. With mass spectrometry-based methods, global…”
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Arteriovenous Blood Metabolomics: A Readout of Intra-Tissue Metabostasis by Ivanisevic, Julijana, Elias, Darlene, Deguchi, Hiroshi, Averell, Patricia M., Kurczy, Michael, Johnson, Caroline H., Tautenhahn, Ralf, Zhu, Zhengjiang, Watrous, Jeramie, Jain, Mohit, Griffin, John, Patti, Gary J., Siuzdak, Gary

“…The human circulatory system consists of arterial blood that delivers nutrients to tissues and venous blood that removes the metabolic by-products. Although it…”
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metaXCMS: Second-Order Analysis of Untargeted Metabolomics Data by Tautenhahn, Ralf, Patti, Gary J, Kalisiak, Ewa, Miyamoto, Takashi, Schmidt, Manuela, Lo, Fang Yin, McBee, Joshua, Baliga, Nitin S, Siuzdak, Gary

“…Mass spectrometry-based untargeted metabolomics often results in the observation of hundreds to thousands of features that are differentially regulated between…”
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Influence of Mass Resolving Power in Orbital Ion-Trap Mass Spectrometry-Based Metabolomics by Najdekr, Lukáš, Friedecký, David, Tautenhahn, Ralf, Pluskal, Tomáš, Wang, Junhua, Huang, Yingying, Adam, Tomáš

“…Modern separation methods in conjunction with high-resolution accurate mass (HRAM) spectrometry can provide an enormous number of features characterized by…”
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Massifquant: open-source Kalman filter-based XC-MS isotope trace feature detection by Conley, Christopher J, Smith, Rob, Torgrip, Ralf J O, Taylor, Ryan M, Tautenhahn, Ralf, Prince, John T

“…Isotope trace (IT) detection is a fundamental step for liquid or gas chromatography mass spectrometry (XC-MS) data analysis that faces a multitude of technical…”
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Meta-Analysis of Untargeted Metabolomic Data: Combining Results from Multiple Profiling Experiments by Patti, Gary J., Tautenhahn, Ralf, Siuzdak, Gary

“…metaXCMS is a software program for the analysis of liquid chromatography/mass spectrometry-based untargeted metabolomic data that is designed to identify…”
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Meta-analysis of global metabolomic data identifies metabolites associated with life-span extension by Patti, Gary J., Tautenhahn, Ralf, Johannsen, Darcy, Kalisiak, Ewa, Ravussin, Eric, Brüning, Jens C., Dillin, Andrew, Siuzdak, Gary

“…The manipulation of distinct signaling pathways and transcription factors has been shown to influence life span in a cell-non-autonomous manner in…”
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Determining conserved metabolic biomarkers from a million database queries by Kurczy, Michael E, Ivanisevic, Julijana, Johnson, Caroline H, Uritboonthai, Winnie, Hoang, Linh, Fang, Mingliang, Hicks, Matthew, Aldebot, Anthony, Rinehart, Duane, Mellander, Lisa J, Tautenhahn, Ralf, Patti, Gary J, Spilker, Mary E, Benton, H Paul, Siuzdak, Gary

“…Metabolite databases provide a unique window into metabolome research allowing the most commonly searched biomarkers to be catalogued. Omic scale metabolite…”
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