Search Results - "Taurog, Joel D."

HLA-B27 and human β2-microglobulin affect the gut microbiota of transgenic rats by Lin, Phoebe, Bach, Mary, Asquith, Mark, Lee, Aaron Y, Akileswaran, Lakshmi, Stauffer, Patrick, Davin, Sean, Pan, Yuzhen, Cambronne, Eric D, Dorris, Martha, Debelius, Justine W, Lauber, Christian L, Ackermann, Gail, Baeza, Yoshiki V, Gill, Tejpal, Knight, Rob, Colbert, Robert A, Taurog, Joel D, Van Gelder, Russell N, Rosenbaum, James T

“…The HLA-B27 gene is a major risk factor for clinical diseases including ankylosing spondylitis, acute anterior uveitis, reactive arthritis, and psoriatic…”
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The Role of HLA-B27 in Spondyloarthritis by TAUROG, Joel D

“…This article summarizes the proceedings of a one-day international workshop held in July 2009 on the role of HLA-B27 in the pathogenesis of ankylosing…”
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Paradoxical Effects of Endoplasmic Reticulum Aminopeptidase 1 Deficiency on HLA–B27 and Its Role as an Epistatic Modifier in Experimental Spondyloarthritis by Tran, Tri M., Gill, Tejpal, Bennett, Joshua, Hong, Sohee, Holt, Vance, Lindstedt, Anders J., Bakshi, Sufia, Sikora, Keith, Taurog, Joel D., Breban, Maxime, Navid, Fatemeh, Colbert, Robert A.

“…Objective We undertook this study to examine the functional basis for epistasis between endoplasmic reticulum aminopeptidase 1 (ERAP1) and HLA–B27 in…”
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The Initiation, but Not the Persistence, of Experimental Spondyloarthritis Is Dependent on Interleukin-23 Signaling by van Tok, Melissa N, Na, Songqing, Lao, Christopher R, Alvi, Marina, Pots, Desirée, van de Sande, Marleen G H, Taurog, Joel D, Sedgwick, Jonathon D, Baeten, Dominique L, van Duivenvoorde, Leonie M

“…IL-17A is a central driver of spondyloarthritis (SpA), its production was originally proposed to be IL-23 dependent. Emerging preclinical and clinical evidence…”
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mTOR Blockade by Rapamycin in Spondyloarthritis: Impact on Inflammation and New Bone Formation in vitro and in vivo by Chen, Sijia, van Tok, Melissa N, Knaup, Véronique L, Kraal, Lianne, Pots, Désiree, Bartels, Lina, Gravallese, Ellen M, Taurog, Joel D, van de Sande, Marleen, van Duivenvoorde, Leonie M, Baeten, Dominique L

“…Spondyloarthritis (SpA) is characterized by inflammation, articular bone erosions and pathologic new bone formation. Targeting TNFα or IL-17A with current…”
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Innate Immune Activation Can Trigger Experimental Spondyloarthritis in HLA-B27/Huβ2m Transgenic Rats by van Tok, Melissa N, Satumtira, Nimman, Dorris, Martha, Pots, Desirée, Slobodin, Gleb, van de Sande, Marleen G, Taurog, Joel D, Baeten, Dominique L, van Duivenvoorde, Leonie M

“…Spondyloarthritis (SpA) does not display the typical features of auto-immune disease. Despite the strong association with MHC class I, CD8 T cells are not…”
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Ankylosing Spondylitis and Axial Spondyloarthritis by Taurog, Joel D, Chhabra, Avneesh, Colbert, Robert A

“…This article summarizes the clinical definition of ankylosing spondylitis and axial spondyloarthritis, discusses the pathogenesis of these conditions, and…”
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Formation of HLA-B27 Homodimers and Their Relationship to Assembly Kinetics by Antoniou, Antony N., Ford, Stuart, Taurog, Joel D., Butcher, Geoffrey W., Powis, Simon J.

“…The human HLA-B27 class I molecule exhibits a strong association with the inflammatory arthritic disorder ankylosing spondylitis and other related…”
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Interleukin‐17A Inhibition Diminishes Inflammation and New Bone Formation in Experimental Spondyloarthritis by Tok, Melissa N., Duivenvoorde, Leonie M., Kramer, Ina, Ingold, Peter, Pfister, Sabina, Roth, Lukas, Blijdorp, Iris C., Sande, Marleen G. H., Taurog, Joel D., Kolbinger, Frank, Baeten, Dominique L.

“…Objective It remains unclear if and how inflammation and new bone formation in spondyloarthritis (SpA) are coupled. We undertook this study to assess the…”
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Three tesla and 3D multiparametric combined imaging evaluation of axial spondyloarthritis and pelvic enthesopathy by Chhabra, Avneesh, Ezzati, Fatemeh, Taurog, Joel D., Xi, Yin, Pezeshk, Parham

“…•Axial spondyloarthritis (SpA) has challenging diagnosis due to temporal findings.•We studied the diagnostic value of 3 T multiparametric combined MR imaging…”
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Corrigendum to “Three tesla and 3D multiparametric combined imaging evaluation of axial spondyloarthritis and pelvic enthesopathy” [Eur. J. Radiol. (2020) 108916] by Chhabra, Avneesh, Ezzati, Fatemeh, Taurog, Joel D., Xi, Yin, Pezeshk, Parham

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The Human Leukocyte Antigen (HLA)-B27 Peptidome in Vivo, in Spondyloarthritis-susceptible HLA-B27 Transgenic Rats and the Effect of Erap1 Deletion by Barnea, Eilon, Melamed Kadosh, Dganit, Haimovich, Yael, Satumtira, Nimman, Dorris, Martha L., Nguyen, Mylinh T., Hammer, Robert E., Tran, Tri M., Colbert, Robert A., Taurog, Joel D., Admon, Arie

“…HLA-B27 is a class I major histocompatibility (MHC-I) allele that confers susceptibility to the rheumatic disease ankylosing spondylitis (AS) by an unknown…”
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Reverse Interferon Signature Is Characteristic of Antigen‐Presenting Cells in Human and Rat Spondyloarthritis by Fert, Ingrid, Cagnard, Nicolas, Glatigny, Simon, Letourneur, Franck, Jacques, Sébastien, Smith, Judith A., Colbert, Robert A., Taurog, Joel D., Chiocchia, Gilles, Araujo, Luiza M., Breban, Maxime

“…Objective In HLA–B27–transgenic rats, the development of a disorder that mimics spondyloarthritis (SpA) is highly correlated with dendritic cell (DC)…”
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The Peptide Repertoire of HLA‐B27 may include Ligands with Lysine at P2 Anchor Position by Yair‐Sabag, Shira, Tedeschi, Valentina, Vitulano, Carolina, Barnea, Eilon, Glaser, Fabian, Melamed Kadosh, Dganit, Taurog, Joel D., Fiorillo, Maria Teresa, Sorrentino, Rosa, Admon, Arie

“…The HLA‐B*27 peptidome has drawn significant attention due to the genetic association between some of the HLA‐B*27 alleles and the inflammatory rheumatic…”
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Role of Protein Phosphatase Magnesium‐Dependent 1A and Anti–Protein Phosphatase Magnesium‐Dependent 1A Autoantibodies in Ankylosing Spondylitis by Kim, Yong‐Gil, Sohn, Dong Hyun, Zhao, Xiaoyan, Sokolove, Jeremy, Lindstrom, Tamsin M., Yoo, Bin, Lee, Chang‐Keun, Reveille, John D., Taurog, Joel D., Robinson, William H.

“…Objective Although ankylosing spondylitis (AS) is driven by immune‐mediated processes, little is known about the presence and role of autoantibodies in this…”
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Cross-sectional imaging of adult crystal and inflammatory arthropathies by Soldatos, Theodoros, Pezeshk, Parham, Ezzati, Fatemeh, Karp, David R., Taurog, Joel D., Chhabra, Avneesh

“…This article highlights the key aspects and current perspectives of the role of cross-sectional imaging in adult crystal and inflammatory arthropathies in…”
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Animal models of spondyloarthritis by Taurog, Joel D

“…Animal models are available for the study of several different aspects of spondyloarthritis. The models include naturally occurring spontaneous disorders in…”
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Erysipelas-like erythema in a patient with familial Mediterranean fever by Breuer, Gabriel S, Taurog, Joel D

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HLA-B27 Misfolding in Transgenic Rats Is Associated with Activation of the Unfolded Protein Response by Turner, Matthew J, Sowders, Dawn P, DeLay, Monica L, Mohapatra, Rajashree, Bai, Shuzhen, Smith, Judith A, Brandewie, Jaclyn R, Taurog, Joel D, Colbert, Robert A

“…The mechanism by which the MHC class I allele, HLA-B27, contributes to spondyloarthritis pathogenesis is unknown. In contrast to other alleles that have been…”
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Loss of bone strength in HLA-B27 transgenic rats is characterized by a high bone turnover and is mainly osteoclast-driven by Rauner, Martina, Thiele, Sylvia, Fert, Ingrid, Araujo, Luiza M, Layh-Schmitt, Gerlinde, Colbert, Robert A, Hofbauer, Christine, Bernhardt, Ricardo, Bürki, Alexander, Schwiedrzik, Jakob, Zysset, Philippe K, Pietschmann, Peter, Taurog, Joel D, Breban, Maxime, Hofbauer, Lorenz C

“…Abstract Objective Although osteopenia is frequent in spondyloarthritis (SpA), the underlying cellular mechanisms and association with other symptoms are…”
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