Search Results - "Taubner, Lara M"
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Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays
Published in PLoS pathogens (01-12-2010)“…A major problem for the effective diagnosis and management of prion diseases is the lack of rapid high-throughput assays to measure low levels of prions. Such…”
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Structure of the Flexible Amino-Terminal Domain of Prion Protein Bound to a Sulfated Glycan
Published in Journal of molecular biology (22-01-2010)“…The intrinsically disordered amino-proximal domain of hamster prion protein (PrP) contains four copies of a highly conserved octapeptide sequence, PHGGGWGQ,…”
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Parallel In-register Intermolecular β-Sheet Architectures for Prion-seeded Prion Protein (PrP) Amyloids
Published in The Journal of biological chemistry (29-08-2014)“…Structures of the infectious form of prion protein (e.g. PrPSc or PrP-Scrapie) remain poorly defined. The prevalent structural models of PrPSc retain most of…”
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Prion protein misfolding and disease
Published in Current opinion in structural biology (01-02-2009)“…Transmissible spongiform encephalopathies (TSEs or prion diseases) are a rare group of invariably fatal neurodegenerative disorders that affect humans and…”
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Structural Studies of Apo Nosl, an Accessory Protein of the Nitrous Oxide Reductase System: Insights from Structural Homology with MerB, a Mercury Resistance Protein
Published in Biochemistry (Easton) (10-10-2006)“…The formation of the unique catalytic tetranuclear copper cluster (CuZ) of nitrous oxide reductase, N2OR, requires the coexpression of a multiprotein assembly…”
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Rapid End-Point Quantitation of Prion Seeding Activity with Sensitivity Comparable to Bioassays: e1001217
Published in PLoS pathogens (01-12-2010)“…A major problem for the effective diagnosis and management of prion diseases is the lack of rapid high-throughput assays to measure low levels of prions. Such…”
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3-O-Desacyl Monophosphoryl Lipid A Derivatives: Synthesis and Immunostimulant Activities
Published in Journal of medicinal chemistry (04-11-1999)“…The synthesis of a series of novel analogues of lipid A, the active principle of lipopolysaccharide, is reported. In these compounds, the 1-O-phosphono and…”
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Efficient method for the t-butyldimethylsilylation of alcohols with N, O-bis( t-butyldimethylsilyl)acetamide
Published in Tetrahedron letters (29-01-1996)“…The efficient t-butyldimethylsilylation of alcohols—including tertiary and sterically hindered secondary alcohols—can be achieved using N, O-bis(…”
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